Endothelial-to-Mesenchymal Transition in Chronic Kidney Disease: Mechanisms and Therapeutic Targets [0.03%]
慢性肾脏病中内皮细胞向间充质细胞转化的机制及治疗靶点
Abdul H Khan,Pratheesh D Mankuzhy,Linto Thomas et al.
Abdul H Khan et al.
Renal fibrosis is the final common pathological outcome of chronic kidney disease (CKD) and a major driver of progression to end-stage kidney disease. Endothelial-to-mesenchymal transition (EndMT) is a phenotypic process in which endothelia...
Prognostic value of claims data for chronic kidney disease associated health risks [0.03%]
保险理赔数据对慢性肾脏病相关风险的预后价值
Sebastian Schwab,Volquart Stoy,Olga Dortmann et al.
Sebastian Schwab et al.
Background: Chronic kidney disease (CKD) associates with kidney failure and overall health risks. We here investigated the prognostic value of claims data in the absence of biochemical data. ...
Verapamil reduces collagen synthesis to alleviate ureteral scar formation by inhibiting KDM1A-mediated epigenetic silencing of SESN2 [0.03%]
维拉帕米通过抑制KDM1A介导的SESN2表观遗传沉默来减少胶原合成以缓解输尿管瘢痕形成
Junhuan He,Jun Li,Xuecheng Wu et al.
Junhuan He et al.
Background: Ureteral scar formation is a fibrotic process linked with collagen synthesis. Although autophagy prevents collagen synthesis, its role in ureteral scarring remains unclear. Therefore, this study investigated t...
Hyperuricaemia induced-hypertension in rats by regulating the RhoA/ ROCK pathway [0.03%]
高尿酸血症性高血压通过调节RhoA/ROCK信号通路诱导血管重塑
Yan Zhang,Zhongchao Wang,Yinli Xu et al.
Yan Zhang et al.
Purpose: Hyperuricaemia (HUA) is associated with hypertension, but the mechanisms remain unclear. This study investigated whether the RhoA/ROCK pathway mediates HUA-induced vascular remodeling and hypertension. ...
Expert opinion on the conceptual, clinical and therapeutic aspects of Fabry nephropathy: A nephrologists' perspective [0.03%]
法布雷肾病的概念、临床和治疗学专家意见（肾脏病医生视角）
Necmi Eren,Kultigin Turkmen,Faruk Turgut et al.
Necmi Eren et al.
Progressive nephropathy (Fabry nephropathy) is one of the main features of Fabry disease observed in both the early-onset and later-onset types and in as many as 50% of males and 20% of females, which largely contributes to the overall dise...
Association of Body Mass Index Trajectories with Kidney Stone Disease: An Analysis Based on the NHANES Database [0.03%]
基于NHANES数据库的体重指数轨迹与肾结石病关联性分析
Weihang Song,Chunfeng Zhang,Zhenhui Li et al.
Weihang Song et al.
Background: Body mass index (BMI), a key indicator of obesity, has been shown by numerous studies to be associated with the risk of kidney stone disease (KSD). However, existing research has predominantly focused on BMI m...
Ascitic Fluid Drainage Before Dialysis Catheter Removal for Peritoneal Dialysis-Related Peritonitis [0.03%]
腹透相关性腹膜炎行导管拔除前穿刺放腹水治疗
Chih-Yuan Lee,Yen-Ya Chen,Jenq-Wen Huang et al.
Chih-Yuan Lee et al.
Introduction Persistent ascites requiring drainage following catheter removal because of peritoneal dialysis (PD)-related peritonitis is a common complication associated with prolonged hospitalization and increased mortality. To mitigate th...
SIRT6 attenuates angiotensin II-induced podocyte cholesterol accumulation and injury via negative modulation of SREBP2 [0.03%]
SIRT6通过抑制SREBP2活性削弱血管紧张素II所致足细胞胆固醇蓄积和损伤
Yingjie Yang,Jingjing Ma,Danqi Chang et al.
Yingjie Yang et al.
Introduction: Angiotensin (Ang) II can cause podocyte injury and leads to chronic kidney disease (CKD), but the specific mechanism is not clear. In our previous study, we found that Ang II reduced the expression of choles...
Epidemiology and multimorbidity in hemodialysis patients at a tertiary care center in northern Mexico: implications for hospital-based adverse outcomes [0.03%]
墨西哥北部一家三级医疗中心血液透析患者的流行病学和多发病：对医院不良预后的启示
Mara Cecilia Olivo-Gutiérrez,Gerardo Mendoza-Lara,Irma Isabel Flores-Ponzio et al.
Mara Cecilia Olivo-Gutiérrez et al.
Introduction: Patients with chronic kidney disease (CKD) in maintenance hemodialysis are vulnerable to adverse hospital-based outcomes. The present study aimed to describe the association between clinical variables and ho...
The inflammatory milieu exacerbates Anemia of CKD: From the gut-kidney axis to bone marrow hematopoiesis inhibition [0.03%]
炎症环境加剧了CKD性贫血：从肠-肾轴到骨髓造血抑制
Na Zhang,Jiaming Han,Xuan Li et al.
Na Zhang et al.
Traditionally, erythropoietin (EPO) deficiency has been known as a central component of the pathophysiology of anemia in chronic kidney disease (CKD). Although renal injury is the primary factor causing EPO deficiency, notably, the efficacy...