miR-200c inhibition and catalase accelerate diabetic wound healing [0.03%]
miR-200c的抑制和过氧化氢酶加速糖尿病伤口愈合
Marco D&#x;Agostino,Sara Sileno,Daniela Lulli et al.
Marco D&#x;Agostino et al.
Background: Reactive oxygen species (ROS) are increased in diabetic conditions and play a causal role in diabetic foot ulcers (DFU). We previously showed that ROS up-regulate miR-200c expression, that in turns causes apop...
PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy [0.03%]
PEX11B棕榈酰化介导过氧化物酶体功能障碍并导致糖尿病神经病变中施万细胞分化失败
Yu Mei Yang,Hang Bin Ma,Yue Xiong et al.
Yu Mei Yang et al.
Background: Diabetic neuropathy (DN) is a prevalent and painful complication of diabetes; however, the mechanisms underlying its pathogenesis remain unclear, and effective clinical treatments are lacking. This study aims ...
Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis [0.03%]
用于治疗细菌性脓毒症的多功能透明质酸仿生/pH响应型杂化纳米结构脂载体系
Eman Elhassan,Calvin A Omolo,Mohammed A Gafar et al.
Eman Elhassan et al.
Introduction: The application of biomimetic and stimuli-responsive nanocarriers displays considerable promise in improving the management of bacterial sepsis and overcoming antimicrobial resistance. Therefore, the study a...
Targeting the fundamentals for tremors: the frequency and amplitude coding in essential tremor [0.03%]
瞄准特发性震颤的根本：特发性震颤的频率和幅度编码
Ming-Kai Pan
Ming-Kai Pan
Essential tremor (ET) is one of the most common movement disorders with heterogeneous pathogenesis involving both genetic and environmental factors, which often results in variable therapeutic outcomes. Despite the diverse etiology, ET is d...
Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence [0.03%]
解锁精准医疗：通过人工智能整合健康记录、遗传学和免疫学的临床应用
Yi-Ming Chen,Tzu-Hung Hsiao,Ching-Heng Lin et al.
Yi-Ming Chen et al.
Artificial intelligence (AI) has emerged as a transformative force in precision medicine, revolutionizing the integration and analysis of health records, genetics, and immunology data. This comprehensive review explores the clinical applica...
Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus [0.03%]
针对耐甲氧西林高毒力金黄色葡萄球菌靶向G-四链体开发新型抗生素策略
Maria Sultan,Maria Razzaq,Joohyun Lee et al.
Maria Sultan et al.
Background: The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited number of established targets furthe...
The Data Artifacts Glossary: a community-based repository for bias on health datasets [0.03%]
医疗数据集偏差的社区型数据库：“数据标本词典”项目
Rodrigo R Gameiro,Naira Link Woite,Christopher M Sauer et al.
Rodrigo R Gameiro et al.
Background: The deployment of Artificial Intelligence (AI) in healthcare has the potential to transform patient care through improved diagnostics, personalized treatment plans, and more efficient resource management. Howe...
Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum [0.03%]
体内疟疾模型的利用以提供对疟原虫Rhoph1/clag必需性及与恶性疟原虫具有保守正交性的功能证据
Mitchell L Trickey,Mrittika Chowdury,Georgina Bramwell et al.
Mitchell L Trickey et al.
Background: Malaria parasites establish new permeation pathways (NPPs) at the red blood cell membrane to facilitate the transport of essential nutrients from the blood plasma into the infected host cell. The NPPs are crit...
Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice [0.03%]
脊髓损伤后神经元DNA损伤的时空规律研究
Elle Em Scheijen,Naomi Veeningen,Sam Duwé et al.
Elle Em Scheijen et al.
Background: Deficient DNA repair and excessive DNA damage contribute to neurodegenerative disease. However, the role of DNA damage and repair in spinal cord injury (SCI) is unclear. SCI, a debilitating disruption of the s...
The endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 3 attenuates the unfolded protein response and has pro-survival and pro-viral roles in hepatoma cells and hepatocellular carcinoma patients [0.03%]
内质网降解增强型α-甘露糖苷酶样蛋白3通过减弱未折叠蛋白数答反应在肝癌细胞和肝细胞癌患者的促存活和促病毒作用中扮演角色
Alina-Veronica Ghionescu,Mihaela Uta,Andrei Sorop et al.
Alina-Veronica Ghionescu et al.
Background: Chronic hepatitis B virus (HBV) infection is a major risk for development of hepatocellular carcinoma (HCC), a frequent malignancy with a poor survival rate. HBV infection results in significant endoplasmic re...