Pyroptosis in ulcerative colitis: biomarkers and therapeutic targets [0.03%]
溃疡性结肠炎中的细胞焦亡：生物标志物和治疗靶点
Hannah Cruz,Prarthna Shah,Nicholas Wohlgemuth et al.
Hannah Cruz et al.
Background: Ulcerative colitis (UC) is one of the two major types of inflammatory bowel disease (IBD), characterized by inflammation of the colon and rectum. The colorectal epithelium, which covers the mucosal surface, ma...
Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin [0.03%]
基于白喉毒素的高HDR活性Cas9变体筛选策略
Daisuke Matsumoto,Komari Kubota,Yu Sato et al.
Daisuke Matsumoto et al.
Background: In gene therapy via genome editing, it is essential to precisely repair disease-associated gene sequences without introducing random mutations. However, achieving highly accurate genome editing remains challen...
The impact of single-nucleotide variants of hepatitis B virus and antiviral on liver cancer in gray zone patients [0.03%]
乙型肝炎病毒单核苷酸变异及其抗病毒治疗对灰区患者肝癌影响的研究
Wei Teng,Ting-Tsung Chang,Chien-Wei Su et al.
Wei Teng et al.
Objectives: This study investigated the impact and related mechanisms of single-nucleotide variants (SNVs) in the HBV pre-S/S region on tumor development, and evaluated the role of antiviral therapy. ...
Publisher Correction: Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates [0.03%]
社论更正：巨噬菌剂对抗金属β-内酰胺酶产生铜绿假单胞菌临床分离株的治疗应用
Paschalis Paranos,Dimitrios Skliros,Nikita Zrelovs et al.
Paschalis Paranos et al.
Published Erratum
Journal of biomedical science. 2025 Nov 24;32(1):105. DOI:10.1186/s12929-025-01200-3 2025
Regulation of the mechanoresponsive Neat1 and PSPC1 by substrate stiffness in TGF-β1-induced renal progenitor cell fate [0.03%]
基质硬度对TGF-β1诱导的肾前体细胞命运中力学响应元件Neat1和PSPC1调控的作用
Hsiao-Ning Huang,Lun-Wei Lee,Cheng-Hsiang Kuo et al.
Hsiao-Ning Huang et al.
Background: Physical differences between acute kidney injury and chronic kidney disease, particularly in matrix stiffness, may influence mesenchymal stem cells to promote either regeneration or fibrosis; however, the unde...
Technological advancements in antibody-based therapeutics for treatment of diseases [0.03%]
抗体治疗技术的进展及其在疾病治疗中的应用
Ruei-Min Lu,Hsiao-Ling Chiang,Joyce Pei-Yi Yuan et al.
Ruei-Min Lu et al.
Monoclonal antibodies (mAbs) represent a major class of therapeutics with widespread clinical applications in oncology, immunology, hematology, neurology and infectious disease. Since the introduction of hybridoma technology in 1975, the fi...
Human liver and pancreas innervation: resolving 3D neurohistological challenges and advancing insights [0.03%]
人肝脏和胰腺的神经支配：解决三维神经组织学难题并加深认识
Chih-Yuan Lee,Fu-Ting Hsiao,Chien-Chia Chen et al.
Chih-Yuan Lee et al.
The human liver and pancreas are central to metabolic regulation, with the autonomic nervous system orchestrating processes that maintain glucose homeostasis and respond to dynamic physiological demands-ranging from acute energy mobilizatio...
Correction: Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models [0.03%]
纠正：NKX3.1和AURKA轴的相互去调控在雄激素剥夺治疗抗性前列腺癌模型及NEPC模型中的作用
Moloud Aflaki Sooreshjani,Mohini Kamra,Amina Zoubeidi et al.
Moloud Aflaki Sooreshjani et al.
Published Erratum
Journal of biomedical science. 2025 Nov 10;32(1):100. DOI:10.1186/s12929-025-01189-9 2025
Human coronavirus OC43 infection in human cerebral organoids: novel insights on pathogenesis and potential therapeutic interventions [0.03%]
人源脑类器官中人类冠状病毒OC43感染：发病机制的新见解及潜在的治疗干预措施
Juntong Liu,Yao Deng,Weibang Huo et al.
Juntong Liu et al.
Background: Since the COVID-19 pandemic, there has been a documented rise in the incidence of neurological manifestations among individuals complicated with encephalitis or myelitis. The spectrum of neurological symptoms ...
Innovative gene engineering and drug delivery systems for dendritic cells in cancer immunotherapy [0.03%]
癌症免疫治疗中用于树突状细胞的创新型基因工程和药物递送系统
Mridula Prakash,Cedric David Cortez,Akshaya Jayaraman et al.
Mridula Prakash et al.
Dendritic cells (DCs) play a crucial role in the coordination of immune responses and have emerged as a potential target for cancer immunotherapy. However, existing DC-based immunotherapies face several clinical challenges, including subopt...