Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia [0.03%]
皮层中缺乏泌素驱动脑缺血中的神经免疫和血管功能障碍
Julia Castillo-González,Pablo Vargas-Rodríguez,Ignacio Serrano-Martínez et al.
Julia Castillo-González et al.
Background: Ischemic stroke remains a leading cause of death and disability, with limited therapies addressing its pathophysiology. Neuroinflammation, blood-brain barrier disruption, and immune dysregulation critically co...
ENT1 inhibitor J4 restores cognitive function and white-matter integrity in a mouse model of tuberous sclerosis complex [0.03%]
ENT1抑制剂J4可恢复TSC小鼠模型的认知功能和白质完整性
Christine Chin-Jung Hsieh,Yi-Syue Tsou,Nai-Kuei Huang et al.
Christine Chin-Jung Hsieh et al.
Background: Tuberous sclerosis complex (TSC) is a hereditary disease caused by pathogenic mutations in the TSC1 or TSC2 genes, leading to overactivation of mTOR signaling and dysregulation of downstream pathways. The majo...
Nuclear PD-L1: an emerging oncogenic driver and promising therapeutic target in cancer [0.03%]
核PD-L1：癌症中新兴的致癌驱动因素和有前景的治疗靶点
Citing Guo,Zenan Fan,Cuiyan Guo et al.
Citing Guo et al.
Programmed cell death-ligand 1 (PD-L1) is best known as a membrane immune checkpoint; however, accumulating evidence indicates that PD-L1 can also localize to the nucleus, where it may exert PD-1-independent, cell-intrinsic functions in can...
Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease [0.03%]
脑外泌体tau蛋白谱分析揭示PHF6肽是阿尔茨海默病病理tau蛋白沉积的核心成分
Marie Oosterlynck,Laura Fichter,Elodie Leroux et al.
Marie Oosterlynck et al.
Background: Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau iso...
Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies [0.03%]
选择性分子和网络结构特征是路易体痴呆伴皮层萎缩的基础
Aline Delva,Stephen Joza,Christina Tremblay et al.
Aline Delva et al.
Background: Dementia with Lewy bodies shares clinical and pathological features with both Parkinson's disease and Alzheimer's disease, but the local biological factors that render specific cortical regions vulnerable to a...
Yan-Ruide Li,Yuning Chen,Lili Yang
Yan-Ruide Li
Chimeric antigen receptor (CAR)-T cells have demonstrated remarkable efficacy in several hematologic malignancies; however, their application in myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) r...
Conditional deletion of Cc2d1a increases irritability-like behavior by decreasing oxytocin expression via the prelimbic-hypothalamic pathway [0.03%]
条件性删除Cc2d1a通过背侧前扣带回-下丘脑通路减少血管紧张素提高烦躁行为
Kuan-Hsiang Cheng,Yu-Chieh Hung,Pin Ling et al.
Kuan-Hsiang Cheng et al.
Background: Dysregulation of the oxytocin (OXT) system is implicated in the pathophysiology of several neuropsychiatric and neurological disorders, particularly autism spectrum disorder (ASD). Our previous study using the...
Andrew Teoh,Mishra Arinjay,Dwaipayan Giri et al.
Andrew Teoh et al.
Ciliopathies frequently involve abnormal brain development and affected individuals often present with varying degrees of cognitive impairment and behavioral alterations. In parallel, genetic studies have linked primary cilia to neurodevelo...
Distinct and combined interferon-ɑ/β-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia [0.03%]
神经元和星形胶质细胞中干扰素-α/β受体-1的单独或联合缺失破坏大脑能量代谢并驱动帕金森病痴呆症状
Erika B Villanueva,Zala Zebec,Marina Cisquella-Serra et al.
Erika B Villanueva et al.
Background: Dysregulated interferon-alpha/beta-receptor 1 (IFNAR1) signaling was recently identified to contribute to the development of sporadic Parkinson's disease (PD) into PD with Dementia (PDD). The molecular, cellul...
Crystal structure of the CD33/Fab-10C8 complex elucidates the mechanism of antibody antagonism in HBV-induced immunosuppression [0.03%]
CD33/Fab-10C8复合物的晶体结构阐明了抗体拮抗在HBV诱导的免疫抑制中的机制
Yi-Hung Yeh,Min-Guan Lin,Pei-Shan Sung et al.
Yi-Hung Yeh et al.
Background: Hepatitis B virus (HBV) infection persists through immune evasion strategies, including engagement of the inhibitory receptor CD33 (Siglec-3) by α2,6-linked sialoglycans on HBsAg. This interaction induces ITI...