The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal [0.03%]
当前的mRNA治疗格局及mRNA净化和dsRNA去除策略
Jin-He Liu,Jian Zang,Jing-Ru Xu et al.
Jin-He Liu et al.
Messenger RNA (mRNA) technology has emerged as a cornerstone in vaccine development and therapeutic applications, offering key benefits such as high potency, rapid scalability, and cost-effectiveness. The success of COVID-19 mRNA vaccines h...
Correction: Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer [0.03%]
锌原卟啉通过阻断血红素氧合酶-1减少肿瘤低氧介导的血管内皮生长因子释放及抗血管生成作用可作为治疗结直肠癌的一种潜在药物：一项更正研究
Chun-Chia Cheng,Siao-Syun Guan,Hao-Jhih Yang et al.
Chun-Chia Cheng et al.
Published Erratum
Journal of biomedical science. 2026 Jul 27;33(1):78. DOI:10.1186/s12929-025-01175-1 2026
Hidden asymptomatic breakthrough infection in a proof-of-concept longitudinal study on SARS-CoV-2 vaccine recipients [0.03%]
SARS-CoV-2疫苗接种者纵向概念验证研究中发现的隐性无症状突破感染
Chiaho Shih,You-Zhen Liao,Che-Yu Hsu et al.
Chiaho Shih et al.
Background: Individuals with asymptomatic SARS-CoV-2 infection can unknowingly transmit the virus, yet identifying such subclinical infections in post-vaccinated populations remains challenging. ...
MPT0E028, a pan-HDAC inhibitor, ameliorates bleomycin-induced pulmonary fibrosis by promoting AT2-to-AT1 differentiation through the ATM/AMPK/FoxO1 pathway [0.03%]
MPT0E028通过ATM/AMPK/FoxO1通路促进AT2向AT1分化从而改善博来霉素诱导的肺纤维化：一种泛组蛋白去乙酰酶抑制剂
Chia-Hao Liu,Hong-Sheng Lee,Jing-Ping Liou et al.
Chia-Hao Liu et al.
Background: Persistent injury and impaired regeneration of the alveolar epithelium are key contributors to the pathogenesis of pulmonary fibrosis. In idiopathic pulmonary fibrosis (IPF), type 2 alveolar epithelial (AT2) c...
Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows robust antiviral activity in cells and mice [0.03%]
emicetine二盐酸盐通过抑制登革病毒nsP2解旋酶发挥抗病毒活性
Anshula Sharma,Chandru Subramani,K A Shouri et al.
Anshula Sharma et al.
Background: Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes frequent global epidemics of chikungunya fever, characterized by severe joint pain and debilitating arthritis. With no specific antiviral therapie...
Photodynamic therapy mediates antitumor effects through multiple non‑apoptotic cell death pathways [0.03%]
光动力疗法通过多种非凋亡细胞死亡途径介导抗肿瘤效应
Kaili Liao,Xiaofei Lin,Hui Liang et al.
Kaili Liao et al.
Photodynamic therapy (PDT) demonstrates remarkable versatility by activating diverse non-apoptotic cell death pathways, effectively circumventing apoptosis resistance and enhancing tumor eradication. Key mechanisms include autophagic cell d...
Arginase-2 enhances monocyte-endothelial interaction through regulation of integrin and membrane receptor expression: role in atherogenesis [0.03%]
精氨酶-2通过调节整合素和膜受体表达增强单核细胞内皮细胞相互作用：在动脉粥样硬化发生中的作用
Guillaume Ajalbert,Yuejun Yao,Sophie Rohrer et al.
Guillaume Ajalbert et al.
Background: Circulating monocyte trans-endothelial migration is critical for vascular diseases. The monocyte surface proteins, i.e., integrins and membrane receptors are central in this process. Previous studies demonstra...
Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells [0.03%]
基于适配体的MNK1抑制通过靶向癌症干细胞减少胰腺导管腺癌生长
Alberto Pérez-Ruiz,Laura Ruiz-Cañas,Sandra Batres et al.
Alberto Pérez-Ruiz et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiven...
Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases [0.03%]
真菌抗药性：从经典机制到乙酰转移酶作用的扩大role_of_acetyltransferases中文通常不会出现，可以省略这个部分。所以最终翻译为：“真菌抗药性：从经典机制到乙酰转移酶的作用扩大”
Silvia Maria Cordeiro Werneck,Ludmila Gouveia-Eufrasio,Gustavo José Cota de Freitas et al.
Silvia Maria Cordeiro Werneck et al.
Antifungal resistance represents a growing global health challenge, driven by limited therapeutic options, inadequate use of both clinical and environmental drugs, and the remarkable adaptive capacity of fungal pathogens. While resistance h...
Calcium and phosphorylation coordination is a novel mechanism that stabilises protein-complexes during HIV assembly [0.03%]
钙和磷酸化协同作用是稳定HIV组装过程中蛋白复合物的新机制
Erwan Brémaud,Biswa Prasanna Mishra,Ablikim Baqi et al.
Erwan Brémaud et al.
Background: Calcium (Ca2+) signalling and phosphorylation are independent mechanisms that regulate diverse biological processes. It is, however, not appreciated that a normal function of phospho-mimic amino acids (asparta...