Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice [0.03%]
阻断SIRPα-CD47轴可促进巨噬细胞吞噬源自内脏脂肪组织的外泌体并改善小鼠炎症和代谢
Yun-Kai Lin,Yu-Fei Pan,Tian-Yi Jiang et al.
Yun-Kai Lin et al.
Background: Adipose tissue plays a pivotal role in systemic metabolism and maintaining bodily homeostasis. Exosomes from adipose tissues, known as AT-Exos, are recognized as important messengers in the communication betwe...
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications [0.03%]
神经肌肉疾病的治疗：基因疗法的突破与未来应用的探索
Yu-Fu Wu,Jun-An Chen,Yuh-Jyh Jong
Yu-Fu Wu
In this review, we highlight recent advancements in adeno-associated virus (AAV)-based gene therapy for genetic neuromuscular diseases (NMDs), focusing on spinal muscular atrophy (SMA) and Duchenne muscular dystrophy (DMD). We discuss the c...
Mitophagy is required to protect against excessive skeletal muscle atrophy following hindlimb immobilization [0.03%]
后肢固定引起的肌肉过度萎缩需要线粒体自噬来保护
Fasih A Rahman,Mackenzie Q Graham,Amanda M Adam et al.
Fasih A Rahman et al.
Background: Skeletal muscle atrophy involves significant remodeling of fibers and is characterized by deficits in mitochondrial content and function. These changes are intimately connected to shifts in mitochondrial turno...
The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5'-3' XRN1-mediated RNA decay pathway in the replication complexes [0.03%]
锌指蛋白ZFP36L2通过作用于复制复合物中的5'-3'XRN1介导的RNA降解途径来抑制黄病毒的感染
Ren-Jye Lin,Li-Hsiung Lin,Zih-Ping Chen et al.
Ren-Jye Lin et al.
Background: The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats f...
miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting [0.03%]
miR-193b-3p通过靶向PRNP抑制肺癌细胞的迁移和侵袭
Hsiang-Ling Ho,Shin-Chih Lin,Chao-Wei Chiang et al.
Hsiang-Ling Ho et al.
Background: Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms of lung cancer metastasis is crucial for developing new treatment strategies. Cellular ...
A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway [0.03%]
登革热病毒的一个非结构蛋白1替换通过干扰抗病毒信号通路增强病毒复制
Jing-Ru Hee,Dayna Cheng,Yu-Hong Chen et al.
Jing-Ru Hee et al.
Background: The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan in 2015, resulting in many fatalities. We therefore aim to identify crucial genetic variations which determine the virulence of the 2015 Taiwan ou...
K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity [0.03%]
Nedd4介导的RORγt K27链接型泛素化增强了Th17介导的自身免疫反应
Qiuming Zeng,Hui Guo,Na Tang et al.
Qiuming Zeng et al.
Background: The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17 cells are believed to play a pivo...
EGF receptor in organ development, tissue homeostasis and regeneration [0.03%]
表皮生长因子受体在器官发育组织稳态及再生中的作用
Claudia Tito,Silvia Masciarelli,Gianni Colotti et al.
Claudia Tito et al.
The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem neural cells. It belongs to the ErbB family, which i...
Intratumoral microbiome: implications for immune modulation and innovative therapeutic strategies in cancer [0.03%]
瘤内微生物群：对癌症免疫调节和创新治疗策略的影响
Na Wang,Si Wu,Lanxiang Huang et al.
Na Wang et al.
Recent advancements have revealed the presence of a microbiome within tumor tissues, underscoring the crucial role of the tumor microbiome in the tumor ecosystem. This review delves into the characteristics of the intratumoral microbiome, u...
Emergence of population heterogeneity in Klebsiella pneumoniae with a blaOXA-232-harboring plasmid: carbapenem resistance, virulence, and fitness [0.03%]
携带blaOXA-232质粒的肺炎克雷伯菌群体异质性的出现：碳青霉烯类耐药性，毒力和健康状况
Yun Young Cho,Sun Ju Kim,Kwan Soo Ko
Yun Young Cho
Background: This study aimed to investigate the population heterogeneity on carbapenem susceptibility in Klebsiella pneumoniae strains that acquired a blaOXA-232-bearing ColE-type plasmid. ...