Multiple roles of branched-chain amino acid metabolism in tumour progression [0.03%]
支链氨基酸代谢在肿瘤进展中的多种作用
Lin Wang,Feng Shi,Ya Cao et al.
Lin Wang et al.
Metabolic reprogramming enables tumour cells to sustain their continuous proliferation and adapt to the ever-changing microenvironment. Branched-chain amino acids (BCAAs) and their metabolites are involved in intracellular protein synthesis...
Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations [0.03%]
HERG激活剂救援重度LQT2突变的分子机制研究
Amit Kumawat,Elisa Tavazzani,Giovanni Lentini et al.
Amit Kumawat et al.
Background: Mutations in the HERG potassium channel are a major cause of long QT syndrome type 2 (LQT2), which can lead to sudden cardiac death. The HERG channel plays a critical role in the repolarization of the myocardi...
Dynamic O-GlcNAcylation and phosphorylation attract and expel proteins from RNA polymerase II to regulate mRNA maturation [0.03%]
动态的O-GlcNAc糖基化和磷酸化通过吸引或排斥RNA聚合酶II复合物上的蛋白质来调节信使核糖核酸成熟加工
Aishwarya Gondane,Harri M Itkonen
Aishwarya Gondane
Background: Phosphorylation and O-GlcNAcylation are the key modifications regulating RNA Polymerase II (RNA Pol II)-driven transcription. Transcriptional kinases, cyclin-dependent kinase 7 (CDK7), CDK9 and CDK12 phosphory...
Surface charge of the C-terminal helix is crucial for antibacterial activity of endolysin against Gram-negative bacteria [0.03%]
C-末端螺旋的表面电荷对于内溶素对抗革兰氏阴性细菌的抗菌活性至关重要
Joonbeom Kim,Su Min Son,Eunbyeol Ahn et al.
Joonbeom Kim et al.
Backgrounds: Endolysins are promising alternatives to antibiotics because they can lyse bacterial cells rapidly with a low risk of resistance development, however, their effectiveness against Gram-negative bacteria is hin...
Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction [0.03%]
腹侧被盖区的催产素信号传导介导了由社会隔离引起的社会互动渴望
Hsin-Tzu Chang,Kuan-Hsiang Cheng,Yu-Chieh Hung et al.
Hsin-Tzu Chang et al.
Background: Social interaction is crucial for mental health across animal species. Social experiences, especially in early-life stages, strongly influence brain function and social behavior later in life. Acute social iso...
Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4 [0.03%]
二甲双胍通过靶向FGFR4使三阴性乳腺癌对组蛋白去乙酰化酶抑制剂敏感
Zhangyuan Gu,Fugui Ye,Hong Luo et al.
Zhangyuan Gu et al.
Background: Triple-negative breast cancer (TNBC) is characterized by high malignancy, strong invasiveness, and a propensity for distant metastasis, leading to poor prognosis and relatively limited treatment options. Metfo...
REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness [0.03%]
REM睡眠质量与清醒时蓝斑的平衡 tonic 活动有关
Nasrin Mortazavi,Puneet Talwar,Ekaterina Koshmanova et al.
Nasrin Mortazavi et al.
Background: Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we invest...
IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment [0.03%]
IL-19作为重新编程胶质母细胞瘤免疫抑制微环境的有希望的治疗靶点
Gilbert Aaron Lee,Justin Bo-Kai Hsu,Yu-Wei Chang et al.
Gilbert Aaron Lee et al.
Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) c...
Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure [0.03%]
超越血管：解开VEGF对神经元功能和结构的影响
Bahar Aksan,Daniela Mauceri
Bahar Aksan
Neurons rely on the bloodstream for essential nutrients and oxygen, which is facilitated by an intricate coupling of the neuronal and vascular systems. Central to this neurovascular interaction is the vascular endothelial growth factor (VEG...
Biological functions and therapeutic applications of human mucosal-associated invariant T cells [0.03%]
人类粘膜相关恒定链T细胞的生物功能及治疗应用
Ying Fang,Yuning Chen,Siyue Niu et al.
Ying Fang et al.
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues,...