Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations [0.03%]
环二鸟苷单磷酸——STING激动剂联合TLR4佐剂的结核分枝杆菌蛋白亚单位疫苗可增强保护作用
Kee Woong Kwon,Eunsol Choi,Hagyu Kim et al.
Kee Woong Kwon et al.
Background: Effective subunit vaccine development requires selecting appropriate adjuvant formulations to trigger desired adaptive immune responses. This study explores the immunogenicity and tuberculosis (TB) vaccine pot...
Meta-epigenetic shifts in T cell aging and aging-related dysfunction [0.03%]
T细胞衰老及相关功能障碍的表观遗传 meta变化
Lorène Rousseau,Karina L Hajdu,Ping-Chih Ho
Lorène Rousseau
Epigenetic regulation, including DNA methylation and histone modifications, play a pivotal role in shaping T cell functionality throughout life. With aging, these epigenetic changes profoundly affect gene expression, altering T cell plastic...
Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing [0.03%]
探索血糖特征的基因组和转录组谱型及旧药新用
Min-Rou Lin,Cheng-Lin Tsai,Cai-Sian Liao et al.
Min-Rou Lin et al.
Background: Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association stud...
Gemcitabine resistance by CITED4 upregulation via the regulation of BIRC2 expression in pancreatic cancer [0.03%]
CITED4通过调节BIRC2表达诱导胰腺癌耐药性gemcitabine的作用机制研究
Eun-Jeong Jeong,Yuna Roh,Eunsun Jung et al.
Eun-Jeong Jeong et al.
Background: Gemcitabine (GEM) is used as a first-line therapy for patients diagnosed with any stage of pancreatic cancer (PC); however, patient survival is poor because of GEM resistance. Thus, new approaches to overcome ...
Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies [0.03%]
哮喘中固有淋巴细胞和似固有淋巴细胞的解码：通向机制和疗法的道路
Christina Li-Ping Thio,Jheng-Syuan Shao,Chia-Hui Luo et al.
Christina Li-Ping Thio et al.
Asthma is a chronic inflammatory lung disease driven by a complex interplay between innate and adaptive immune components. Among these, innate lymphoid cells (ILCs) and innate-like lymphocytes have emerged as crucial players in shaping the ...
Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes [0.03%]
角蛋白6A通过黑素细胞中JAK1-STAT3活化促进皮肤炎症反应
Mengting Chen,Yaling Wang,Mei Wang et al.
Mengting Chen et al.
Background: Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacer...
Accelerating antibody discovery and optimization with high-throughput experimentation and machine learning [0.03%]
利用高通量实验和机器学习加速抗体的发现与优化
Ryo Matsunaga,Kouhei Tsumoto
Ryo Matsunaga
The integration of high-throughput experimentation and machine learning is transforming data-driven antibody engineering, revolutionizing the discovery and optimization of antibody therapeutics. These approaches employ extensive datasets co...
Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA [0.03%]
表征SARS-CoV-2奥密克戎变异株肽段与人群特异性HLA结合亲和力的变化
Che-Mai Chang,Chang-Jiun Wu,Maxim Shkurnikov et al.
Che-Mai Chang et al.
Background: The evolution of SARS-CoV-2, particularly through new variants, presents significant global health challenges due to their potential for immune evasion and reduced vaccine effectiveness. This study aims to inv...
Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice [0.03%]
小鼠杏仁核/终纹床核(ASIC4阳性)神经元中缺乏ASIC1a可降低焦虑和先天性恐惧
Ya-Chih Chien,Shing-Hong Lin,Cheng-Chang Lien et al.
Ya-Chih Chien et al.
Background: Anxiety is an innate response in the face of danger. When anxiety is overwhelming or persistent, it could be considered an anxiety disorder. Recent studies have shown that acid-sensing ion channels (ASICs) rep...
Correction: K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity [0.03%]
关于Nedd4介导的RORγt泛素化修饰促进Th17相关自身免疫反应的订正原文：Correction: K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity
Qiuming Zeng,Hui Guo,Na Tang et al.
Qiuming Zeng et al.
Published Erratum
Journal of biomedical science. 2025 Apr 16;32(1):42. DOI:10.1186/s12929-025-01136-8 2025