Chitosan-based formulations for therapeutic applications. A recent overview [0.03%]
用于药物应用的壳聚糖制剂近期概述
Weronika Gonciarz,Ewa Balcerczak,Marek Brzeziński et al.
Weronika Gonciarz et al.
Chitosan is a cationic natural polymer composed of glucosamine and N-acetylglucosamine residues that are held together by a glycosidic bond. Chitosan has many excellent properties, including physicochemical properties, i.e., stability in th...
Cardiac-specific overexpression of PRMT5 exacerbates pressure overload-induced hypertrophy and heart failure [0.03%]
心脏特异性过表达PRMT5可加剧压力超负荷诱导的心肌肥厚和心力衰竭
Yasufumi Katanasaka,Yoichi Sunagawa,Ryoga Sakurai et al.
Yasufumi Katanasaka et al.
Background: Various epigenetic modifiers are involved in the regulation of gene expression during pathological cardiac hypertrophy-a critical event in the development of heart failure. Our previous research has demonstrat...
The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder [0.03%]
内源大麻素系统-肠菌群-脑轴在自闭症治疗中的新潜力
Antonella Campanale,Dario Siniscalco,Vincenzo Di Marzo
Antonella Campanale
Introduction: Autism spectrum disorder (ASD) is characterized by disruption of the gut-brain axis, which leads to behavioral, psychiatric, metabolic and gastrointestinal symptoms. Effective ASD treatments are limited. Res...
The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation [0.03%]
ACE2 decoy受体可克服快速突变的SARS-CoV-2逃逸免疫并减少细胞因子诱导和凝块形成
Ming-Shiu Lin,Tai-Ling Chao,Yu-Chi Chou et al.
Ming-Shiu Lin et al.
Background: The COVID-19 pandemic continues to affect the world in 2025. The rapid mutation of SARS-CoV-2 results in breakthrough infections and diminishes the efficacy of vaccines and anti-viral drugs. The severity of th...
Association of antibody and T cell receptor repertoires in Trypanosoma cruzi infected rhesus macaques and host response to infection [0.03%]
抗体和T细胞受体在感染刚地芽生菌的恒河猴中的联合以及宿主对感染的反应
Rachel M Clear,Weihong Tu,Kelly Goff et al.
Rachel M Clear et al.
Background: Chagas disease, caused by Trypanosoma cruzi parasites, leads to chronic cardiac disease in 20-40% of infected patients, while the majority remain asymptomatic. The mechanisms and drivers of pathogenesis are st...
Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration [0.03%]
靶向神经炎症：3-单硫阿巴西普，一种新的药物候选者，可减轻创伤性脑损伤和神经退行性疾病
Shih Chang Hsueh,Pathik Parekh,Buyandelger Batsaikhan et al.
Shih Chang Hsueh et al.
Background: Traumatic Brain Injury (TBI) is a major risk factor for neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD), with neuroinflammation playing a critical role in the secondar...
Involvement of nucleic acid-sensing toll-like receptors in human diseases and their controlling mechanisms [0.03%]
核酸感应 Toll 样受体在人类疾病中的作用及其调控机制
You-Sheng Lin,Yung-Chi Chang,Tzu-Yu Pu et al.
You-Sheng Lin et al.
The innate immune system is the host's initial response to eliminate pathogens and repair tissue damage. Innate immune cells, such as macrophages and dendritic cells, use pattern recognition receptors (PRRs) to recognize microbial structure...
Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185 [0.03%]
益生菌通过调节miR-185改善幽门螺杆菌相关胃β-连环蛋白和COX-2致癌信号
Yao-Jong Yang,Chung-Tai Wu,Hsiu-Chi Cheng et al.
Yao-Jong Yang et al.
Background: This study aimed to investigate whether probiotics can ameliorate the H. pylori-induced Wnt/β-catenin-related COX-2 carcinogenesis signaling pathway by regulating the expression of microRNAs (miRNAs). ...
USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression [0.03%]
USP24上调通过稳定PKA-Cα促进MASH进展过程中的脂质生成、炎症和纤维化
Beh Ning,Shao-An Wang,Ming-Jer Young et al.
Beh Ning et al.
Background: Ubiquitin-specific peptidase 24 (USP24), a deubiquitinating enzyme, regulates protein stability by removing ubiquitin. This study investigates the role of UPS24 in lipid metabolism, inflammation, and fibrosis....
AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA [0.03%]
鲍曼不动杆菌中的AbOmpA：探索外膜整合及外膜囊泡相关AbOmpA的毒力机制并开发针对AbOmpA的抗感染药物
Man Hwan Oh,Md Minarul Islam,Nayeong Kim et al.
Man Hwan Oh et al.
Acinetobacter baumannii is notorious for its antimicrobial resistance and its potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism is traditionally considered a low-virulence path...