Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts [0.03%]
基于医院和基于人群的亚洲队列中的全外显子测序及多基因风险评分在肾功能临床管理中的应用
Min-Rou Lin,I-Wen Wu,Wan-Hsuan Chou et al.
Min-Rou Lin et al.
Background: Taiwan has the highest prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) globally, making them major public health concerns with significant morbidity, mortality, and healthcare bu...
Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting [0.03%]
糖代谢及其在癌症和免疫调节中的直接作用：针对代谢途径的机遇与挑战
Bo-Syong Pan,Che-Chia Hsu,Hsin-En Wu et al.
Bo-Syong Pan et al.
Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, s...
Shih-Ho Lin,Shan-Hui Hsu
Shih-Ho Lin
The application of smart hydrogels has become a booming research frontier in biomedical engineering. With the development of intelligent drug delivery systems, various biomimetic and biodegradable hydrogels are employed for localized drug d...
Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer [0.03%]
猫肉瘤蛋白S在白细胞介素-7介导的抗肿瘤免疫中的调节机制及其在口腔癌症治疗中的靶向潜力研究
Yung-Chieh Chang,Szu-Jung Chen,Shang-Hung Chen et al.
Yung-Chieh Chang et al.
Background: Immunomodulatory agents benefit a small percentage of patients with oral cancer (OC), a subset of head and neck cancer. Cathepsin S (CTSS), a lysosomal protease, has been frequently associated with tumor immun...
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway [0.03%]
肥胖通过激活PPARD/PDK4/ANGPTL4信号途径诱导胃壁肌层平滑肌表型转换
Sanaa Dekkar,Kamilia Mahloul,Amandine Falco et al.
Sanaa Dekkar et al.
Background: Clinical research has identified stomach dysmotility as a common feature of obesity. However, the specific mechanisms driving gastric emptying dysfunction in patients with obesity remain largely unknown. In th...
Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes [0.03%]
同罪关联：与四跨膜蛋白CD63的直接相互作用表明有机阳离子转运体3在嗜酸性粒细胞组胺释放中的作用
Moritz Pernecker,Miriam Dibos,Sophie Götz et al.
Moritz Pernecker et al.
Background: The organic cation transporter 3 (OCT3) is a ubiquitous transporter that carries both endogenous and exogenous substrates, such as histamine and cisplatin. Our investigations have shown that OCT3 directly inte...
Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis [0.03%]
艰难梭状芽胞杆菌与腺苷系统：操控宿主稳态的技巧
Katia Fettucciari,Luigi Cari,Andrea Spaterna et al.
Katia Fettucciari et al.
Background: Adenosine is a ubiquitous endogenous molecule capable of influencing several pathophysiological aspects. The adenosine system is extremely complex, starting from the generation of intracellular and extracellul...
A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy [0.03%]
一种新型的β-TrCP1/NRF2相互作用抑制剂有效抗炎治疗
Ángel J García-Yagüe,Lucía Cañizares-Moscato,José Antonio Encinar et al.
Ángel J García-Yagüe et al.
Background: Non-communicable chronic diseases are characterized by low-grade inflammation and oxidative stress. Extensive research has identified the transcription factor NRF2 as a potential therapeutic target. Current NR...
Correction: Interference in melanoma CD248 function reduces vascular mimicry and metastasis [0.03%]
纠正：干扰素作用于黑色素瘤CD248功能可降低血管模仿和转移作用
Cheng-Hsiang Kuo,Ya-Fang Wu,Bi-Ing Chang et al.
Cheng-Hsiang Kuo et al.
Published Erratum
Journal of biomedical science. 2025 Jul 11;32(1):64. DOI:10.1186/s12929-025-01155-5 2025
Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells [0.03%]
杯状细胞破坏：转录组学揭示阿米巴伯克霍尔德菌在分化的人支气管上皮细胞中早期且强大的炎症反应
Daniela Scribano,Claudia Tito,Astri D Tagueha et al.
Daniela Scribano et al.
Background: The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. However, in the last years, pneumonia caused by the opport...