Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in hyperexcitability during status epilepticus [0.03%]
BDNF-TrkB信号传导对NMDA受体GluN2B介导的突触可塑性和反复性癫痫发作过程中过度兴奋的作用
Pasqualino De Luca,Miranda Mele,Sara Tanqueiro et al.
Pasqualino De Luca et al.
Background: Brain-derived neurotrophic factor (BDNF) is a key mediator of synaptic plasticity and memory formation in the hippocampus. However, the BDNF-induced alterations in the glutamate receptors coupled to the plasti...
Fto-mediated m6A modification is essential for cerebellar development through regulating epigenetic reprogramming [0.03%]
FTO介导的m6A修饰通过调控表观重编程对小脑发育是必不可少的
Jing Jiang,Ming Zhang,Wenjuan Xia et al.
Jing Jiang et al.
Background: Growing evidence highlights the importance of epitranscriptomic regulation in cerebellar development and function, especially through m6A methylation. Nevertheless, the precise function of the RNA demethylase ...
Correction: Cardiac-specific overexpression of PRMT5 exacerbates pressure overload-induced hypertrophy and heart failure [0.03%]
纠正：心脏特异性过表达PRMT5加重压力超负荷诱导的肥大和心力衰竭
Yasufumi Katanasaka,Yoichi Sunagawa,Ryoga Sakurai et al.
Yasufumi Katanasaka et al.
Published Erratum
Journal of biomedical science. 2025 Aug 26;32(1):80. DOI:10.1186/s12929-025-01174-2 2025
CDK4/6 inhibitors synergize with radiotherapy to prime the tumor microenvironment and enhance the antitumor effect of anti-PD-L1 immunotherapy in triple-negative breast cancer [0.03%]
CDK4/6抑制剂可与放疗协同，为肿瘤微环境做准备，并增强抗PD-L1免疫治疗在三阴性乳腺癌中的抗肿瘤作用
Wen-Chi Yang,Ming-Feng Wei,Ying-Chun Shen et al.
Wen-Chi Yang et al.
Background: Triple-negative breast cancer (TNBC) has the highest mortality rate among all breast cancer subtypes. Although immunotherapy shows promise, its efficacy varies. CDK4/6 inhibitors can radiosensitize and modulat...
Smooth muscle-specific expression of hydroxyindole O-methyltransferase reduces arterial injury-induced intimal hyperplasia [0.03%]
平滑肌特异性表达羟基吲哚O-甲基转移酶可降低动脉损伤引起的内膜增生
Wei-Cheng Jiang,Chung-Huang Chen,Hua-Hui Ho et al.
Wei-Cheng Jiang et al.
Background: The pineal gland produces melatonin to control circadian rhythm via the final enzyme in the serotonin pathway, hydroxyindole O-methyltransferase (HIOMT). Interestingly, HIOMT is expressed by certain non-pineal...
Activation of mitophagy and proteasomal degradation confers resistance to developmental defects in postnatal skeletal muscle [0.03%]
线粒体自噬和蛋白酶体降解的激活赋予了对出生后骨骼肌发育缺陷的抵抗力
Fasih A Rahman,Mackenzie Q Graham,Alex Truong et al.
Fasih A Rahman et al.
Background: Postnatal skeletal muscle development leads to increased muscle mass, strength, and mitochondrial function, but the role of mitochondrial remodeling during this period is unclear. This study investigates mitoc...
Qi Yan,Nan Duan,Mingqun Lin et al.
Qi Yan et al.
Background: Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligato...
Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates [0.03%]
一种巨型噬菌体的药物应用及其对抗产生金属β-内酰胺酶的临床分离型绿脓杆菌疗法
Paschalis Paranos,Dimitrios Skliros,Nikita Zrelovs et al.
Paschalis Paranos et al.
Background: Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically ...
Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator [0.03%]
核PKM2：信号接收器、基因编程器和代谢调节剂
Tsan-Jan Chen,Chun-Hsien Wu,Mien-Chie Hung et al.
Tsan-Jan Chen et al.
Pyruvate kinase M2 (PKM2) is a key enzyme involved in glycolysis, yet its role in cancer extends far beyond metabolic flux. Unlike its isoform PKM1, PKM2 exhibits unique regulatory properties due to alternative splicing and dynamic structur...
CD24a knockout results in an enhanced macrophage- and CD8⁺ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model [0.03%]
CD24a敲除通过增强肿瘤微环境中的巨噬细胞和CD8⁺T细胞介导的抗肿瘤免疫应答抑制小鼠三阴性乳腺癌的发展
Shih-Hsuan Chan,Chin-Yu Lin,Hsuan-Jung Tseng et al.
Shih-Hsuan Chan et al.
Background: CD24 plays a crucial role not only in promoting tumor progression and metastasis but also in modulating macrophage-mediated anti-tumor immunity. However, its impact on the immune landscape of the tumor microen...