The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans [0.03%]
从酵母到人类：不同形式的饮食限制对寿命和衰老的影响
Tsui-Ting Ching,Ao-Lin Hsu
Tsui-Ting Ching
Dietary restriction (DR) refers to a broad set of interventions that limit the intake of specific nutrients or overall food consumption, either in quantity or timing, without causing malnutrition. DR has long been considered the most robust...
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans [0.03%]
不同节食方案对生物衰老和寿命的影响：从酵母到人类
Tsui-Ting Ching,Ao-Lin Hsu
Tsui-Ting Ching
Dietary restriction (DR) refers to a broad set of interventions that limit the intake of specific nutrients or overall food consumption, either in quantity or timing, without causing malnutrition. DR has long been considered the most robust...
Ether-lipids accumulation promotes hepatocellular carcinoma progression linked to PPARα deficiency [0.03%]
与PPARα缺乏相关的以醚脂质累积促进肝癌进展
Pei-Yin Liao,Wen-Jen Lin,Pei-Chun Shen et al.
Pei-Yin Liao et al.
Background: While the Warburg effect links glycolysis to de novo lipid synthesis in carcinogenesis, the roles of lipids in cancer prognosis remain elusive. Here, a multi-omics approach was conducted in a cohort of hepatoc...
Retraction Note: Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes [0.03%]
撤回 notice:多巴胺D2受体在缺血/再灌注诱发的新生大鼠心肌细胞凋亡中的作用
Hong-Zhu Li,Jin Guo,Jun Gao et al.
Hong-Zhu Li et al.
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region [0.03%]
PPM1D通过羧基末端区域以泛素非依赖性方式直接被蛋白酶体降解
Masaki Takahashi,Takeshi Kondo,Shogo Kimura et al.
Masaki Takahashi et al.
Background: PPM1D (protein phosphatase Mg2⁺/Mn2⁺ dependent 1D) is a Ser/Thr phosphatase that negatively regulates p53 and functions as an oncogenic driver. Its gene amplification and overexpression are frequently observ...
TCA cycle-derived oncometabolites in cancer and the immune microenvironment [0.03%]
与癌症及其免疫微环境相关的三羧酸循环衍生的肿瘤代谢物
Shukla Sarkar,Chien-I Chang,Jussekia Jean et al.
Shukla Sarkar et al.
Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydrox...
Coxsackie B1 virus-like particle vaccine modified to exclude a highly conserved immunoreactive region from the capsid induces potent neutralizing antibodies and protects against infection in mice [0.03%]
移除衣壳高度保守的抗原决定簇后构建的柯萨奇B1病毒样颗粒疫苗能够诱导中和抗体并保护小鼠免受病毒感染
Saana Soppela,Martín González-Rodríguez,Virginia M Stone et al.
Saana Soppela et al.
Background: Enteroviruses, including Coxsackie B (CVB) viruses, can cause severe diseases such as myocarditis, pancreatitis, and meningitis. Vaccines can prevent these complications, but conserved non-neutralizing epitope...
Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity [0.03%]
慢性耳毒性期间前庭感觉上皮中毛细胞特异性基因早期下调
Mireia Borrajo,Erin A Greguske,Alberto F Maroto et al.
Mireia Borrajo et al.
Background: Exposure of mammals to ototoxic compounds causes hair cell (HC) loss in the vestibular sensory epithelia of the inner ear. In chronic exposure models, this loss often occurs by extrusion of the HC from the sen...
Extracellular vesicles: biogenesis mechanism and impacts on tumor immune microenvironment [0.03%]
细胞外囊泡的生物发生机制及其对肿瘤免疫微环境的影响
Nai Yang Yeat,Ruey-Hwa Chen
Nai Yang Yeat
Extracellular vesicles (EVs) are heterogeneous populations of membrane-bound particles released from almost all cell types in an organism and play pivotal roles in cell-cell communication. EVs carry nucleic acids, proteins, metabolites and ...
Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development [0.03%]
衰老和流体切应力对血管内皮代谢及动脉粥样硬化的影响
Wei-Li Wang,Yu-Tsung Shih,Shu-Yi Wei et al.
Wei-Li Wang et al.
Aging is the foremost risk factor for metabolic syndrome and atherosclerosis, which is a principal cause of cardiovascular diseases (CVDs). Vascular endothelial cells (ECs), which line the vascular intima, play a central role in maintaining...