An approach to the immunophenotypic features of circulating CD4⁺NKG2D⁺ T cells in invasive cervical carcinoma [0.03%]
探讨浸润性宫颈癌外周血CD4+NKG2D+T细胞免疫表型特征的方法
Mariel Garcia-Chagollan,Luis Felipe Jave-Suarez,Jesse Haramati et al.
Mariel Garcia-Chagollan et al.
Background: NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8(+) T cells. The existence of an atypical cytotoxic CD4(+)NKG2D(+) T cell population has also been found in patients with autoimm...
Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells [0.03%]
肌球蛋白在转化生长因子β1诱导的乳腺癌上皮间质转换中的作用
Zhi-Yuan Chen,Pei-Wen Wang,Dar-Bin Shieh et al.
Zhi-Yuan Chen et al.
Background: Increasing evidence suggests that transforming growth factor-beta 1 (TGF-β1) triggers epithelial to mesenchymal transition (EMT) and facilitates breast cancer stem cell differentiation. Gelsolin (GSN) is a ub...
Preparation, characterization and immunological evaluation: canine parvovirus synthetic peptide loaded PLGA nanoparticles [0.03%]
用于负载犬细小病毒合成肽的PLGA纳米粒的制备、表征及其免疫学评价研究
Serap Derman,Zeynep Akdeste Mustafaeva,Emrah Sefik Abamor et al.
Serap Derman et al.
Background: Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 o...
DNA methylation regulates mouse cardiac myofibril gene expression during heart development [0.03%]
DNA甲基化在小鼠心脏发育过程中调控心肌节律基因表达
Yang Xu,Lingjuan Liu,Bo Pan et al.
Yang Xu et al.
Background: It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of feta...
FcγRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK [0.03%]
FcγRIIB通过Btk和p38 MAPK介导人类B淋巴细胞的非依赖抗原的抑制作用
Shiang-Jong Tzeng,Wan-Yu Li,Hui-Ying Wang
Shiang-Jong Tzeng
Background: The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative regulator of B cell activation and as such is predicted to play an essential role in controlling antibody-mediated autoimmune diseases in hum...
Intravenous injection of microvesicle-delivery miR-130b alleviates high-fat diet-induced obesity in C57BL/6 mice through translational repression of PPAR-γ [0.03%]
微囊递送miR-130b静脉给药通过抑制PPAR-γ蛋白翻译缓解C57BL/6小鼠高脂饮食诱导的肥胖效应
Shifeng Pan,Xiaojing Yang,Yimin Jia et al.
Shifeng Pan et al.
Background: We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fa...
Aleksey V Belikov,Burkhart Schraven,Luca Simeoni
Aleksey V Belikov
Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a weapon of phagocytes, employed against pathogens invadin...
Daisy Vanitha John,Yee-Shin Lin,Guey Chuen Perng
Daisy Vanitha John
Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in affected individuals. The earl...
Vitamin A depletion induced by cigarette smoke is associated with an increase in lung cancer-related markers in rats [0.03%]
吸烟诱导的大鼠维生素A缺乏与肺癌相关标记物的增加有关
Yuan Xue,Ethan Harris,Weiqun Wang et al.
Yuan Xue et al.
Background: We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation of tracheal precancerous lesions. However, the underlying mechani...
Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord [0.03%]
吡格列酮对吗啡诱导的大鼠腰脊髓神经炎症的保护作用
Mohammad Charkhpour,Hamed Ghavimi,Saeed Ghanbarzadeh et al.
Mohammad Charkhpour et al.
Background: Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated re...