Hung-Chun Liao,Shih-Jen Liu
Hung-Chun Liao
Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to the COVID-19 pandemic. The widespread administration of mRNA vaccines against COVID-19 to billions globally...
Targeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis [0.03%]
靶向丙酮酸激酶M2通过YWHAZ/Parkin轴逆转硼替佐米耐药性/MM细胞凋亡诱导剂的研究
Xuejie Gao,Qilin Feng,Qikai Zhang et al.
Xuejie Gao et al.
Background: Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond glycolysis in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this...
N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis [0.03%]
N6-甲基腺苷RNA修饰通过KDM6B和GATA3调节SLC7A11的转录以调节铁死亡
Haisheng Zhang,Cheng Yi,Jianing Li et al.
Haisheng Zhang et al.
Background: Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation. ...
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA [0.03%]
新型人类特异性长链非编码RNA MEK6-AS1通过稳定MEK6 mRNA调节脂肪细胞分化和脂质合成
Di Li,Yunhua Chen,Xingyu Zhu et al.
Di Li et al.
Background: Obesity is becoming one of the major non-communicable diseases with increasing incidence and risks that cannot be ignored. However effective and safe clinical treatment strategies still need to be deeply explo...
Fusobacterium nucleatum promotes colorectal cancer liver metastasis via miR-5692a/IL-8 axis by inducing epithelial-mesenchymal transition [0.03%]
福斯杆菌通过诱导上皮间质转化促进结直肠癌肝转移的机制研究
Yulong Yu,Han Yin,Bili Wu et al.
Yulong Yu et al.
Background: The association between the intestinal microbiota and colorectal cancer (CRC) has been extensively studied, with Fusobacterium nucleatum (F. nucleatum, FN) being found in high abundance in colorectal cancer ti...
Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health [0.03%]
蚊媒黄病毒致病过程中细胞外囊泡的作用及其对公共健康的影响
Pedro Pablo Martínez-Rojas,Verónica Monroy-Martínez,Blanca H Ruiz-Ordaz
Pedro Pablo Martínez-Rojas
Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and the potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular fa...
Raluca E Ghebosu,Lawrence Hui,Joy Wolfram
Raluca E Ghebosu
The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of concl...
HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC [0.03%]
乙型和丙型肝炎病毒双重感染的肝细胞癌中HBV DNA整合及体细胞突变谱系显示介于HBV-和HCV相关肝癌之间特征
Chiao-Ling Li,Chia-Lang Hsu,You-Yu Lin et al.
Chiao-Ling Li et al.
Background: In regions with a high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, coinfected patients face a heightened risk of developing hepatocellular carcinoma (HCC), termed HBV/...
Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis [0.03%]
重新评估氧化性DNA碱基损伤8-氧代鸟嘌呤和修复酶OGG1在肿瘤发生中的作用
Jing Wang,Chunshuang Li,Jinling Han et al.
Jing Wang et al.
ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A d...
Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management [0.03%]
调控者中的调控者：长非编码RNA作为慢性疾病管理中自噬控制器的作用
Aviral Kumar,Kenneth Chun-Hong Yap,Bandari BharathwajChetty et al.
Aviral Kumar et al.
The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strategies. Autophagy, a conserved bi...