Passage-dependent biological characteristics of acute-phase human ACL-derived cells [0.03%]
与时间相关的急性期人前交叉韧带来源细胞的生物学特性
Jinsung Park,Tae-Hwan Kim,Jin Kyu Lee
Jinsung Park
Introduction Anterior cruciate ligament (ACL)-derived cells have emerged as a promising autologous cell source for ligament tissue engineering and graft augmentation. However, although these cells are commonly expanded in vitro prior to app...
Enhancing the culture of mouse primary fibroblasts to study age-dependent effects in skin tissue engineering in vitro [0.03%]
通过体外培养小鼠原代成纤维细胞研究皮肤组织工程中年龄相关性效应
Laura Casado Mayo,Micah Wingell,Chanelle A Moise et al.
Laura Casado Mayo et al.
Aged dermal fibroblasts exhibit reduced migration, proliferation, and extracellular matrix (ECM) production, alongside upregulation of pro-inflammatory signaling that disrupts the proliferative, granulation, and remodeling phases of wound h...
Role of the Proteasome System in Shaping Cellular Immunological Characteristics and Its Impact in Modulating the Pathogenesis of Immune-Related Diseases [0.03%]
蛋白酶体系统在塑造细胞免疫学特征中的作用及其对调节免疫相关疾病发病机制的影响
Ejlal Abu-El-Rub,Hana M Zegallai,Ramada Khasawneh et al.
Ejlal Abu-El-Rub et al.
The 26S proteasome degradation system is a central regulator of protein homeostasis and immune function, integrating antigen processing, inflammatory signaling, and cell fate decisions. Dysregulation of this system has profound consequences...
Allyson C Deihl,Augustine Oboseoye Odibo,Jhonatan A Gutierrez-Rivera et al.
Allyson C Deihl et al.
Background: Bioelectrical signaling, a collection of electrical currents driven mainly by ionic fluxes and transmembrane potential gradients, is recognized as a central regulator of cell behavior, tissue patterning, and r...
Miki Aizawa,Masakazu Kinoshita,Kunihiro Sakuma
Miki Aizawa
Calcineurin-NFAT is an important pathway that regulates skeletal muscle regeneration. Homer 2 that modulates signal transduction in the central nervous system directly binds to NFATc1. However, its role is not fully understood in skeletal m...
Integrating Cells, Biomaterials, and Advanced Engineering for Next-Generation Peripheral Nerve Repair [0.03%]
集细胞、生物材料和高级工程技术于一体用于下一代外周神经修复
Gabriel Leonard Galahad Declercq,Shang Song
Gabriel Leonard Galahad Declercq
Background: Peripheral nerve injuries (PNIs) disrupt sensory and motor circuits, affecting millions worldwide and often resulting in lasting functional deficits. Autologous nerve grafting remains the surgical benchmark fo...
Rapid, Growth Factor-Reduced Induction of Functional Neurons from hiPSCs [0.03%]
快速且无需生长因子的诱导人hiPSCs成为功能性的神经元细胞
Natalie A Parker,Oluwadamilola E Kolawole,Zhixin Liao et al.
Natalie A Parker et al.
Introduction: Human induced pluripotent stem cells (hiPSCs) can be rapidly converted into neurons via Neurogenin-2 (NGN2) overexpression, but many protocols require costly reagents during the initial induction phase that ...
Mechanisms of cell plasticity during injury-induced epithelial reprogramming [0.03%]
损伤诱导的上皮细胞重编程过程中的细胞可塑性机制
Evelyn Mazzarelli,Sara Lovisa
Evelyn Mazzarelli
Background: Plasticity defines the capacity to change identity in response to stimuli and represents a property intrinsically inherited from embryonic development. The homeostatic epithelial turnover of many organs is gua...
Andres F Roca-Arroyo,Jhonatan A Gutierrez-Rivera,Laura M Mejia-Rosales et al.
Andres F Roca-Arroyo et al.
Background: Hydrogels are widely used as ECM-mimetic biomaterials, but most lack the nanofibrous hierarchy of the native extracellular matrix, which is essential for regulating human stem cells (hSCs) behavior. Nanofibrou...
Comparative Analysis of Temperature-Dependent Endocytic Regulation of Notch Signaling in Chick and Mouse Neural Progenitors [0.03%]
鸡和小鼠神经前体细胞中温度依赖性内吞调节的 notch 信号通路的比较分析
Kai-Wei Lin,Pei-Rong Wu,Cheng-Chang Chen et al.
Kai-Wei Lin et al.
Temperature plays a crucial role in embryonic development, particularly in oviparous species that experience natural fluctuations during incubation. Unlike viviparous embryos developing under stable maternal conditions, chick embryos are ex...