Sequential JAK Inhibitor Switching in Ulcerative Colitis Patients Maintaining Remission: A Multicenter Experience [0.03%]
Genta Uchida,Tsunaki Sawada,Masanao Nakamura et al.
Genta Uchida et al.
Introduction: Given the safety concerns associated with the long-term use of Janus kinase (JAK) inhibitors, establishing effective "exit strategies" is crucial for patients with ulcerative colitis (UC). This study investi...
Potassium-Competitive Acid Blocker Increases Ileal Permeability and Exacerbates Ileal Inflammation under Stress Conditions in a Mouse Model of Eosinophilic Enteritis [0.03%]
Kei Yamamoto,Fumio Tanaka,Yu Nishida et al.
Kei Yamamoto et al.
Introduction: Potassium-competitive acid blockers (P-CABs) have been empirically administered to treat non-esophageal eosinophilic gastrointestinal diseases, although their efficacy remains unproven. Our previous findings...
Association of Equol Production Status with the Presence of Precancerous Colorectal Lesions in Japan [0.03%]
Yoshihiro Kaneta,Taiki Yamaji,Kouji Harada et al.
Yoshihiro Kaneta et al.
Introduction: Epidemiological evidence regarding the association between equol and precancerous colorectal lesions, including adenomas, sessile serrated lesions, and traditional serrated adenomas, remains unclear. Moreove...
Autoantibodies are useful in monitoring disease activity and predicting relapses in autoimmune pancreatitis [0.03%]
自身抗体在自身免疫性胰腺炎中可用于监测疾病活动度及预测复发
Lena Falk,Katharina Murillo,Matthias P Ebert et al.
Lena Falk et al.
INTRODUCTION Autoimmune pancreatitis (AiP) is an inflammatory disease typically treated with corticosteroids. But repeated corticosteroid treatment (CST) can cause significant side effects, raising the need for better management strategies....
Diagnosis of Eosinophilic Enteritis Using Double-Balloon Enteroscopy-Guided Multisite Biopsies [0.03%]
双气囊小肠镜引导下多点活检诊断嗜酸细胞性肠炎
Takeshi Yamashina,Masaaki Shimatani,Tatsuya Nakagawa et al.
Takeshi Yamashina et al.
Objective: Eosinophilic enteritis (EoN) remains underrecognized because of nonspecific symptoms and difficulty obtaining deep small intestinal biopsies. We evaluated the diagnostic utility of double-balloon enteroscopy (D...
Bifidobacterium bifidum G9-1 and Quality of Life in Chronic Constipation: A Multicenter, Double-blind, Randomized Controlled Trial [0.03%]
长链型双歧杆菌G9-1对慢性便秘患者生活质量的影响：多中心、随机对照试验
Noboru Misawa,Takaomi Kessoku,Kojiro Inoue et al.
Noboru Misawa et al.
Introduction: Patients with constipation often experience impaired quality of life (QOL). A previous open-label study of Bifidobacterium bifidum G9-1 (BBG9-1) in patients with chronic constipation reported a significant i...
Beyond Helicobacter pylori: Current Insights into H. pylori-Naive Gastric Cancer [0.03%]
赫尔利 obacter pylori：无Hp感染胃癌的最新认识
Samuel W D Woo,Valerie S X Yeap,Victor S F Hau et al.
Samuel W D Woo et al.
Background: The increasing global incidence of Helicobacter pylori-naive gastric cancer (HPnGC) has established it as a clinical entity warranting further study of its diagnosis, pathogenesis, etiologies, classifications,...
Short- and Long-Term Outcomes of Mirikizumab for Ulcerative Colitis: A Real-World Multicenter Retrospective Cohort Study from the INSIGHT study [0.03%]
Mirikizumab治疗溃疡性结肠炎短期及长期结局的回顾性队列研究：来自INSIGHT研究的真实世界数据
Tsunaki Sawada,Takeshi Yamamura,Keiko Maeda et al.
Tsunaki Sawada et al.
Introduction: Mirikizumab (MIR), a selective IL-23p19 inhibitor, has shown efficacy in clinical trials for ulcerative colitis (UC). However, real-world data, especially on long-term outcomes and in treatment-experienced p...
Involvement of gastrointestinal functional disorder in the management of inflammatory bowel disease [0.03%]
胃肠功能紊乱在炎症性肠病管理中的作用
Ruby Arai,Masayuki Fukata
Ruby Arai
Recent therapeutic advances have yielded higher remission rates than before in patients with inflammatory bowel disease (IBD), while many patients in remission still experience gastrointestinal symptoms. These persistent symptoms could be c...
Diagnosis of Functional Dyspepsia and Novel Gastrointestinal Functional Assessments [0.03%]
功能性消化不良的诊断及新型胃肠功能评估方法
Tsutomu Takeda,Mariko Hojo,Akihito Nagahara
Tsutomu Takeda
Background: Functional dyspepsia (FD) is a common disorder of gut-brain interaction characterized by postprandial distress and epigastric pain, which significantly impairs quality of life and increases healthcare burden. ...