Upstream stimulating factor 2 aggravates neuropathic pain induced in spinal nerve ligation-induced mice via regulating SNHG5/miR-181b-5p [0.03%]
上游刺激因子2通过调节SNHG5/miR-181b-5p加剧脊神经结扎诱导的小鼠神经病理性疼痛
Mi Chen,Yang Yang,Jiatian Cui et al.
Mi Chen et al.
Background: Upstream stimulating factor 2 (USF2) belongs to basic-Helix-Loop-Helix-Leucine Zipper transcription factor family, regulating expression of genes involved in immune response or energy metabolism network. Role ...
Identification of differentially expressed miRNA in the rat hippocampus during adolescence through an epigenome-wide analysis [0.03%]
利用表观基因组范围分析识别大鼠青春期海马中差异表达的miRNA
Ana Vázquez-Ágredos,Paula Rovira,Blanca Gutiérrez et al.
Ana Vázquez-Ágredos et al.
Introduction: Epigenetic mechanisms involving microRNAs (miRNAs) play a fundamental role in many biological processes, particularly during prenatal and early postnatal development. Their role in adolescent brain developme...
Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat [0.03%]
Fmr1基因敲除大鼠海马区信息处理的 septotemporal变异
Leonidas J Leontiadis,Panagiotis Felemegkas,George Trompoukis et al.
Leonidas J Leontiadis et al.
Introduction Fragile X messenger ribonucleoprotein (FMRP) is a protein involved in many neuronal processes in the nervous system including the modulation of synaptic transmission. Loss of FMRP produces the fragile X syndrome (FXS), a neurod...
Sex-specific behavioural deficits in adulthood following acute activation of the GABAA receptor in the neonatal mouse [0.03%]
新生儿小鼠GABAA受体急性激活导致成年期性别特异性行为缺陷
Ane Goikolea-Vives,Cathy Fernandes,Michael S C Thomas et al.
Ane Goikolea-Vives et al.
Introduction: Sex differences exist in the prevalence of neurodevelopmental disorders (NDDs). Part of the aetiology of NDDs has been proposed to be alterations in the balance between excitatory and inhibitory neurotransmi...
Central Autonomic Network and heart rate variability in premature neonates [0.03%]
早产新生儿中枢自主神经网络和心率变异性
Kelsey Christoffel,Josepheen De Asis-Cruz,Rathinaswamy B Govindan et al.
Kelsey Christoffel et al.
Introduction: The Central Autonomic Network (CAN) is a hierarchy of brain structures that collectively influence cardiac autonomic input, mediating the majority of brain-heart interactions, but has never been studied in p...
Pain/Stress, Mitochondrial Dysfunction and Neurodevelopment in Preterm Infants [0.03%]
早产儿的疼痛/压力、线粒体功能障碍和神经发育
Tingting Zhao,Xiaolin Chang,Subrata Kumar Biswas et al.
Tingting Zhao et al.
Introduction Preterm infants experience tremendous early life pain/stress during their neonatal intensive care unit (NICU) hospitalization, which impacts their neurodevelopmental outcomes. Mitochondrial function/dysfunction may interface be...
Identification and functional study of enhancers of EYA1, the causative gene of branchio-oto-renal syndrome [0.03%]
BRORS致病基因EYA1的增强子鉴定及功能研究
Feng Wang,Ruizhi Zhang,Jing Jian et al.
Feng Wang et al.
Introduction: Branchio-oto-renal syndrome (BOR syndrome) is a rare genetic disorder with an incidence of 1 in 40,000, affecting the development of multiple organs, including the branchio, ear and kidney. It is responsible...
Developmental regulation of matrix metalloproteinases in response to multi-factorial, severe TBI injuries during immaturity [0.03%]
在发育不成熟期间，多因素严重TBI损伤后基质金属蛋白酶的发育调控反应
Alexandra Hochstetler,George Price,Amy Baohan et al.
Alexandra Hochstetler et al.
Introduction: A striking pattern in young children after severe TBI is when the entire cortical ribbon displays tissue damage: hemispheric hypodensity (HH). HH is often a result of abusive head trauma (AHT). We previously...
SRSF3 alleviates ischemic cerebral infarction damage by activating PI3K/Akt pathway [0.03%]
SRSF3通过激活PI3K/Akt信号通路缓解缺血性脑梗死损伤
Liangliang Cui,Shuying Zhao,Hong Liu
Liangliang Cui
Ischemic cerebral infarction is one of cerebrovascular diseases with high incidence, disability rate and mortality globally, and neuronal cell apoptosis is a crucial cause of brain injury during cerebral infarction. A middle cerebral artery...
Oxidative stress accompanies HIF1-dependent impairment of glucose metabolism in the hippocampus of adult rats survived prenatal severe hypoxia [0.03%]
缺氧诱导因子HIF-1介导的海马糖代谢障碍伴氧化应激状态及其对学习记忆的影响
Oleg Vetrovoy,Viktor Stratilov,Sofiya Potapova et al.
Oleg Vetrovoy et al.
Introduction: Many socially significant diseases are associated with prenatal developmental disorders. Previously, we showed the pathological role of hypoxia-inducible factor HIF1 in post-hypoxic reoxygenation. This study...