Abnormal Magnetic Resonance Imaging in the Medial Prefrontal Cortex Following Prenatal Alcohol Exposure and Placental Insufficiency in a Preclinical Model [0.03%]
酒精致宫内暴露和胎盘功能不全的小鼠海马磁共振成像异常性研究
Zarena M Dominguez,Suzy Davies,Yousuf Amer et al.
Zarena M Dominguez et al.
Introduction: The combination of Prenatal Alcohol Exposure (PAE) and Placental Insufficiency (PI) places infants at an increased risk for preterm birth and may worsen brain injury and neurobehavioral outcomes. In this pre...
Imbalanced innervation of the hypothalamic paraventricular nucleus by the AgRP and α-MSH axonal projections in germ-free mice [0.03%]
无菌小鼠下丘脑室旁核接受AgRP和α-MSH轴突投射的不平衡支配
Oarii Vahirua,Mouna El Mehdi,Emilie Lahaye et al.
Oarii Vahirua et al.
Introduction: Innervation of the paraventricular nucleus of the hypothalamus (PVN) by the orexigenic agouti-related protein (AgRP) and anorexigenic α-melanocyte-stimulating hormone (α-MSH) neurons of the arcuate nucleus...
Small for Gestational Age and Motor Development in Children: A Narrative Review of Risk Factors, Brain Mechanisms, and Early Interventions [0.03%]
胎龄小于胎龄儿与儿童运动发育：风险因素、大脑机制及早期干预的叙述性综述
Liuyan Zhu,Dan Yao
Liuyan Zhu
Background: Small for gestational age (SGA) infants face a heightened risk of motor delays that can persist into childhood, affecting cognitive and language development. Early identification and intervention are critical ...
Genetic characterization of 128 Chinese individuals with neurodevelopmental disorders via whole-exome sequencing [0.03%]
通过外显子组测序对中国神经发育障碍患者的基因特征进行刻画
Yayun Qin,Huang Cao,Lijun Liu et al.
Yayun Qin et al.
Introduction: Neurodevelopmental disorders (NDDs) are chronic conditions marked by abnormal brain development, presenting with significant clinical heterogeneity. Early diagnosis is crucial but challenging due to the comp...
Subtype- and Layer-Specific Developmental Gradients of Postnatal GABAergic Neurons in the Rodent Barrel Cortex [0.03%]
鼠 Barrel 大脑皮层中GABA能神经元的亚型和分层特异性的产后发育梯度
Henna Kallo,Violetta Sitdikova,Anatolii Logashkin et al.
Henna Kallo et al.
Introduction: The developing brain exhibits rostro-caudal gradients that align with the maturation of functionally organized circuits. The barrel cortex, a spatially precise sensory structure, serves as an ideal model to ...
Comparative Single Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices [0.03%]
发育中 frontal 和 visual 皮层中表达和不表达 c-met 体的投射神经元的单细胞转录组分析比较
Ramin Ali Marandi Ghoddousi,Pat Levitt,Zia Rady et al.
Ramin Ali Marandi Ghoddousi et al.
Introduction: Single cell transcriptomic analyses in adult mice show that cortical projection neuron (PN) subclasses exhibit heterogenous gene expression profiles that reflect their projection targets, and laminar and are...
Association between cold-inducible RNA binding motif 3 and hypothermia effect in murine hypoxia-ischemia model measured by metabolic MRI [0.03%]
冷诱导RNA结合基元3与小鼠缺氧-缺血模型低体温效应的关联性研究——基于代谢MRI的方法学探索
Xiaodan Liu,Xiangning Jiang,Alkisti Mikrogeorgiou Capper et al.
Xiaodan Liu et al.
Introduction: The efficacy of therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) is inconsistent, and the cause remains unclear. This study aimed to explore the role of cold stress protein in ...
Expanding Insights into KCTD7-Related Drug-Resistant Epilepsy: Three Novel Mutations in a Cohort of Iranian Pediatric Patients [0.03%]
KCTD7相关性难治性癫痫的致病机制及临床特征研究——伊朗儿童患者队列中的3种新型突变
Sima Binaafar,Reza Shervin Badv,Ali Rashidi-Nezhad et al.
Sima Binaafar et al.
KCTD7-related epilepsy is a rare neurogenetic disorder characterized by marked genetic and phenotypic heterogeneity, typically presenting with early onset and often exhibiting poor response to conventional antiseizure medications. We perfor...
Association of Umbilical Cord Blood Serotonin Levels with Neurodevelopmental Outcomes [0.03%]
新生儿脐带血清素水平与神经发育结局的关系研究
Kally C O Apos Reilly Sparks,Lauren C Shuffrey,Rebecca N Siegel et al.
Kally C O Apos Reilly Sparks et al.
Introduction: Serotonin (5-hydroxytryptamine [5-HT]) plays an important role in early development, and fetal 5-HT has been reported to arise from placental and maternal sources. Previous human studies have established an ...
Human apolipoprotein E ε4 allele modulates energy substrate availability, seizure burden, mortality and hippocampal injury, cell death and inflammation after neonatal hypoxic-ischemic brain injury [0.03%]
人源性载脂蛋白ε4等位基因调节缺氧缺血性脑损伤后能量底物的可用性、发作负荷、死亡率和海马损伤、细胞死亡及炎症反应
Michelle Nazareth,Sarah Ann Duck,Abigail Fassinger et al.
Michelle Nazareth et al.
Introduction: Human apolipoprotein E allele ε4 (ApoE4) is the strongest genetic risk factor for some forms of adulthood neurodegeneration linked to energetic disturbances and inflammation. We hypothesized that ApoE4 also...