Targeting Poison Exons to Treat Developmental and Epileptic Encephalopathy [0.03%]
靶向毒害外显子以治疗发育性和癫痫性脑病
Miriam C Aziz,Patricia N Schneider,Gemma L Carvill
Miriam C Aziz
Developmental and epileptic encephalopathies (DEEs) describe a subset of neurodevelopmental disorders categorized by refractory epilepsy that is often associated with intellectual disability and autism spectrum disorder. The majority of DEE...
CRISPR/dCas9 as a Therapeutic Approach for Neurodevelopmental Disorders: Innovations and Limitations Compared to Traditional Strategies [0.03%]
CRISPR/dCas9在神经发育障碍治疗中的应用：与传统策略的创新和局限性比较
Raffaele Ricci,Gaia Colasante
Raffaele Ricci
Brain development is a complex process that requires a series of precise and coordinated events to take place. When alterations in some of those events occur, neurodevelopmental disorders (NDDs) may appear, with their characteristic symptom...
Adverse Maternal Environment Alters MicroRNA-10b-5p Expression and Its Epigenetic Profile Concurrently with Impaired Hippocampal Neurogenesis in Male Mouse Hippocampus [0.03%]
不良的母体环境同时改变雄性小鼠海马体microRNA-10b-5p表达及其表观遗传谱并导致神经发生受损
Xingrao Ke,Yingliu Huang,Qi Fu et al.
Xingrao Ke et al.
An adverse maternal environment (AME) predisposes adult offspring toward cognitive impairment in humans and mice. However, the underlying mechanisms remain poorly understood. Epigenetic changes in response to environmental exposure may be c...
Current Approaches and Future Directions for the Treatment of mTORopathies [0.03%]
当前治疗mTOR障碍的方法及未来发展方向
Vasiliki Karalis,Helen S Bateup
Vasiliki Karalis
The mechanistic target of rapamycin (mTOR) is a kinase at the center of an evolutionarily conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds to an array of intra- and extracellular stimuli and in turn co...
Can Ozlu,Rachel M Bailey,Sarah Sinnett et al.
Can Ozlu et al.
Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders that disrupt normal brain development. Though some NDDs are caused by acquired insults (i.e., toxic or infectious encephalopathy) or may be cryptogenic, many NDDs are...
Repetitive Mild Traumatic Brain Injury in a Perinatal Nicotine Exposure Mouse Model of Attention Deficit Hyperactivity Disorder [0.03%]
围产期尼古丁暴露注意缺陷多动障碍小鼠模型中重复性轻度脑外伤
Lin Zhang,Cathy W Levenson,Valentina Cea Salazar et al.
Lin Zhang et al.
Attention deficit hyperactivity disorder (ADHD) increases the risk for concussion or mild traumatic brain injury (mTBI). At the same time, recommendations for the management of ADHD include participation in sports and other organized physic...
Aluminum Microcomb Electrodes on Silicon Wafer for Detecting Val66Met Polymorphism in Brain-Derived Neurotrophic Factor [0.03%]
硅片铝微梳电极检测脑源性神经营养因子Val66Met多态性
Zhi Li,Liangmin Cui,Hongyao Zhao et al.
Zhi Li et al.
Objective: Brain-derived neurotrophic factor (BDNF) dysregulation is widely related with various psychiatric and neurological disorders, including schizophrenia, depression, Rett syndrome, and addiction, and the available...
Long Noncoding RNA SPRY4-IT1 Modulates Ketamine-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons through EZH2 [0.03%]
长非编码RNA SPRY4-IT1通过EZH2调节氯胺酮诱导的由人胚胎干细胞分化而来的神经元的毒性作用
Jingyuan Huang,Yan Xu,Fang Wang et al.
Jingyuan Huang et al.
Objective: This study aimed to investigate whether long noncoding RNA sprouty receptor tyrosine kinase signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is involved in the regulation of ketamine-induced neurotoxici...
Meike E van der Heijden,Jason S Gill,Roy V Sillitoe
Meike E van der Heijden
Autism spectrum disorders (ASD) comprise a group of heterogeneous neurodevelopmental conditions characterized by impaired social interactions and repetitive behaviors with symptom onset in early infancy. The genetic risks for ASD have long ...
A Role for Vasoactive Intestinal Peptide Interneurons in Neurodevelopmental Disorders [0.03%]
血管活性肠肽间神经元在神经发育障碍中的作用
Kevin M Goff,Ethan M Goldberg
Kevin M Goff
GABAergic inhibitory interneurons of the cerebral cortex expressing vasoactive intestinal peptide (VIP-INs) are rapidly emerging as important regulators of network dynamics and normal circuit development. Several recent studies have also id...