Alterations in the Stool Microbiome in Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy [0.03%]
新生儿缺氧缺血性脑病后接受轻度亚低温治疗的婴儿肠道微生物群的变化
Ammee A D Gala,Himanshu Kumar,Sagar Sedani et al.
Ammee A D Gala et al.
Background: Hypoxic-ischemic encephalopathy (HIE) is associated with brain injury in newborns and may lead to disability or death. Mild therapeutic hypothermia (TH) is an effective neuroprotective intervention and an esta...
Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia [0.03%]
维生素E可降低细胞毒性并缓解新生幼獺缺氧缺血脑组织片中炎症和氧化应激反应
Sarah Kolnik,Kylie Corry,Kate Hildahl et al.
Sarah Kolnik et al.
The gyrencephalic ferret brain is an excellent model in which to study hypoxia-ischemia (HI), a significant contributor to neurological injury in neonates. Vitamin E, an essential fat-soluble antioxidant, reduces oxidative stress and inflam...
The Utility of Cerebral Autoregulation Indices in Detecting Severe Brain Injury Varies by Cooling Treatment Phase in Neonates with Hypoxic-Ischemic Encephalopathy [0.03%]
亚低温治疗不同阶段缺氧缺血性脑病新生儿脑自主调节指数对严重脑损伤的预测价值不同
May W Chen,Jennifer K Lee,Gilbert Vezina et al.
May W Chen et al.
Identifying the hemodynamic range that best supports cerebral perfusion using near infrared spectroscopy (NIRS) autoregulation monitoring is a potential physiologic marker for neonatal hypoxic-ischemic encephalopathy (HIE) during therapeuti...
Observational Study
Developmental neuroscience. 2022;44(4-5):363-372. DOI:10.1159/000522314 2022
The Difference in the Cytoskeletal Machinery of Growth Cones of Growing Axons and Leading Processes [0.03%]
生长轴突生长锥和引领进程的细胞骨架装置差异性分析
Kaho Miyata,Kensuke Hayashi
Kaho Miyata
Neuronal migration and axon elongation in the developing brain are essential events for neural network formation. Leading processes of migrating neurons and elongating axons have growth cones at their tips. Cytoskeletal machinery for advanc...
Influence of Testosterone Depletion on Neurotrophin-4 in Hippocampal Synaptic Plasticity and Its Effects on Learning and Memory [0.03%]
睾酮缺乏对海马区神经营养素-4的表观遗传调控及其对突触可塑性、学习和记忆的影响研究
Sakthi Jothi Muthu,Ganesh Lakshmanan,Prakash Seppan
Sakthi Jothi Muthu
Sex steroids are neuromodulators that play a crucial role in learning, memory, and synaptic plasticity, providing circuit flexibility and dynamic functional connectivity in mammals. Previous studies indicate that testosterone is crucial for...
Developmental Iron Deficiency Dysregulates TET Activity and DNA Hydroxymethylation in the Rat Hippocampus and Cerebellum [0.03%]
铁缺乏影响DNA去甲基化酶TET的活性和DNA羟甲基化水平的发展失调：大鼠海马和小脑的研究
Amanda Barks,Montana M Beeson,Timothy C Hallstrom et al.
Amanda Barks et al.
Iron deficiency (ID) during neurodevelopment is associated with lasting cognitive and socioemotional deficits and increased risk for neuropsychiatric disease throughout the lifespan. These neurophenotypical changes are underlain by gene dys...
Promotion of the Differentiation of Dental Pulp Stem Cells into Oligodendrocytes by Knockdown of Heat Shock Protein 27 [0.03%]
热休克蛋白27敲低促进牙髓干细胞向少突胶质细胞分化
Shu-Lin Guo,Chih-Hui Chin,Chi-Jung Huang et al.
Shu-Lin Guo et al.
Stem cell-based therapy has been evaluated in many different clinical trials for various diseases. This capability was applied in various neurodegenerative diseases, such as multiple sclerosis, which is characterized by demyelination, axona...
A Novel Variant of the KIF11 Gene, c.2922G>T, Is Associated with Microcephaly by Affecting RNA Splicing [0.03%]
KIF11基因新型变异c.2922G>T通过影响RNA剪接导致小头畸形
Zhenglong Guo,Xiaodong Huo,Dong Wu et al.
Zhenglong Guo et al.
Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) is an inherited disorder characterized by severe microcephaly and abnormal facial features. Kinesin family member 11 (KIF11) mutations have been repor...
Case Reports
Developmental neuroscience. 2022;44(2):113-120. DOI:10.1159/000518923 2022
Bioinformatic Analysis Reveals the Distinct Role of 5'UTR-Specific m6A RNA Modification in Mice Developing Cerebral Cortices [0.03%]
生物信息学分析揭示了5'-UTR特异性mRNA修饰在小鼠大脑皮层发育中的独特作用
Long-Bin Zhang,Ting-Ting Qiu,Wu-Wei-Jie Yang
Long-Bin Zhang
N6-methyladenosine (m6A) abundantly exists in the cerebral cortex and is emerging as an essential factor in cortical development and function. As the m6A-binding site appears to be dynamically methylated in different RNA regions at the temp...
L-Ascorbic Acid and Curcumin Prevents Brain Damage Induced via Lead Acetate in Rats: Possible Mechanisms [0.03%]
L-抗坏血酸和姜黄素通过醋酸铅诱导的脑损伤预防大鼠的脑损伤：可能的机制
Ahlam Mohamed Alhusaini,Laila M Fadda,Huda Alsharafi et al.
Ahlam Mohamed Alhusaini et al.
Lead acetate (lead ac.) is a widespread ecological toxicant that can cause marked neurotoxicity and decline in brain functions. This study aimed to evaluate the possible neuroprotective role of L-ascorbic acid (ASCR) and curcumin (CRCM) alo...