Short Juvenile Stress Has No Long-Lasting Effects on Anxiety-Like Behavior, Object Recognition Memory, or Gross Brain Morphology but Affects Dendritic Spines in the Hippocampus in Male Rats [0.03%]
短期早年应激对成年大鼠无长期影响但会影响海马齿状回树突棘的数量和形态
Silvana Regina de Melo,Lucas B Gremaschi,Luiz Felipe M S B Blanco et al.
Silvana Regina de Melo et al.
Purpose: During the juvenile stage, such areas as the hippocampus and corpus callosum (CC) are still immature and sensitive to stress exposure. The present study investigated whether two different types of stressors in th...
Deficits in Seizure Threshold and Other Behaviors in Adult Mice without Gross Neuroanatomic Injury after Late Gestation Transient Prenatal Hypoxia [0.03%]
晚孕期短暂宫内缺氧后无明显神经解剖损伤的成年小鼠出现惊厥阈值和其他行为异常
Ana G Cristancho,Elyse C Gadra,Ima M Samba et al.
Ana G Cristancho et al.
Intrauterine hypoxia is a common cause of brain injury in children resulting in a broad spectrum of long-term neurodevelopmental sequela, including life-long disabilities that can occur even in the absence of severe neuroanatomic damage. Po...
The Vannucci Model of Hypoxic-Ischemic Injury in the Neonatal Rodent: 40 years Later [0.03%]
建模40年后的缺氧缺血性损伤的小鼠模型：范努奇小鼠模型
Susan J Vannucci,Stephen A Back
Susan J Vannucci
Perinatal hypoxic-ischemic (HI) brain damage has long been a major cause of acute mortality and chronic neurological morbidity in infants and children. Experimental animal models are essential to gain insights into the pathogenesis and mana...
Brain Outcomes in Runted Piglets: A Translational Model of Fetal Growth Restriction [0.03%]
生长受限猪崽的脑部结局：胎儿生长受限的转化模型
Kirat K Chand,Kerstin Pannek,Paul B Colditz et al.
Kirat K Chand et al.
Fetal growth restriction (FGR) is associated with long-term neurodevelopmental disabilities including learning and behavioral disorders, autism, and cerebral palsy. Persistent changes in brain structure and function that are associated with...
Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development [0.03%]
Cep152的表达分析：一种负责遗传性自闭症基因产物在小鼠脑发育过程中的表达分析研究
Nanako Hamada,Mariko Noda,Hidenori Ito et al.
Nanako Hamada et al.
Centrosomal protein 152 (Cep152) regulates centriole duplication as a molecular scaffold during the cell cycle. Its gene abnormalities are responsible for autosomal recessive primary microcephaly 9 and Seckel syndrome. In this study, we pre...
Research Progress of Collapse Response Mediator Proteins in Neurodegenerative Diseases [0.03%]
神经退行性疾病中崩溃反应介导蛋白的研究进展
Kun Qin,Shaoye Xu,Yu Han et al.
Kun Qin et al.
Collapse response mediator proteins (CRMPs) are a family of cytoplasmic phosphorylated proteins, and the mechanism of action has always been the research focus of neurological diseases. Previous studies on the CRMPs family have revealed tha...
Association between Multi-Organ Involvement and Brain Injury in Cooled Newborns: A Statistical Approach [0.03%]
低温新生儿多器官受累与脑损伤的相关性研究：一种统计学方法
Viraj Padhiar,Gabriel Rosser,Nicola Openshaw-Lawrence et al.
Viraj Padhiar et al.
Introduction: In the event of fetal hypoxia-ischemia, circulation to the brain and central organs is thought to be preserved. The objective of the study was to explore the relationship between the presence of brain injury...
Repeated Neonatal Exposure to Sevoflurane Induces Age-Dependent Impairments in Cognition and Synaptic Plasticity in Mice [0.03%]
反复暴露于异氟醚致新生小鼠年龄依赖性认知障碍及突触可塑性损伤
Xiaoyan Zhao,Dongjing Shi,Yingjie Du et al.
Xiaoyan Zhao et al.
Background: Sevoflurane is a volatile anesthetic that is widely used in pediatric anesthesia due to its low toxicity. However, whether neonatal exposure to sevoflurane induces long-lasting cognitive impairment remains unc...
Guido Wassink,Steven Harrison,Simerdeep Dhillon et al.
Guido Wassink et al.
Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging and neurodevelopmental outcomes. Critically, for effective neuroprotection,...
Hae-Won Son,Declan William Ali
Hae-Won Son
The endocannabinoid system (ECS) is widely studied due to its interactions with cannabis and its role in modulating physiological responses. While most research has focused on the effects of cannabis on adult ECSs, recent studies have begun...