Epileptiform Events and Kainate Receptor Activity Changes Considerably during Entorhinal Cortex Development: An ex vivo Study [0.03%]
内侧颞叶发育过程中杏仁环路中癫痫样放电及kainite受体活性的改变：脑片切片研究
Tímea Májer,Katalin Szádeczky-Kardoss,Sándor Borbély et al.
Tímea Májer et al.
Epilepsy is a commonly diagnosed neurological disease, which often develops already in childhood. The prominent feature of this dysfunction is the strong, unprovoked hypersynchronous neuronal activity of the brain, especially in the cortex,...
Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice [0.03%]
一种评估新生儿缺氧缺血后小鼠脑损伤的新伤情评分工具
Burak Ozaydin,Ela Bicki,Onur E Taparli et al.
Burak Ozaydin et al.
The variability of severity in hypoxia-ischemia (HI)-induced brain injury among research subjects is a major challenge in developmental brain injury research. Our laboratory developed a novel injury scoring tool based on our gross pathologi...
Testosterone Influence on Microtubule-Associated Proteins and Spine Density in Hippocampus: Implications on Learning and Memory [0.03%]
睾酮对海马微管相关蛋白及突触的影响：对学习记忆的启示
Sakthi Jothi Muthu,Ganesh Lakshmanan,Khayinmi Wungpam Shimray et al.
Sakthi Jothi Muthu et al.
The thorny protrusions or spines increase the neuronal surface area, facilitate synaptic interconnections among neurons, and play an essential role in the hippocampus. Increasing evidence suggests that testosterone, the gonadal hormone, pla...
Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia [0.03%]
绵羊中度围生期缺氧缺血模型长期结局的评估方法
Jana Krystofova Mike,Katherine Y Wu,Yasmine White et al.
Jana Krystofova Mike et al.
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal morbidity and mortality worldwide. Approximately 1 million infants born with HIE each year survive with cerebral palsy and/or serious cognitive disabilities. While infan...
Perineuronal Nets Degradation and Parvalbumin Interneuron Loss in a Mouse Model of DEPDC5-Related Epilepsy [0.03%]
DEPDC5相关性癫痫小鼠模型中的神经节苷脂降解和钙调蛋白神经元丢失
Tao Yang,Shuntong Hu,Wei-Chih Chang et al.
Tao Yang et al.
DEPDC5, the key gene within the mechanistic target of rapamycin (mTOR) pathway, is one of the most common causative genes in patients with epilepsy and malformation of cortical development (MCD). Although somatic mutations in the dorsal cor...
Ye Zhang,Yan-Yun Sun,Min Xu et al.
Ye Zhang et al.
Astrocytes are the most common glial type in the central nervous system. They play pivotal roles in neurophysiological and neuropathological processes. Mounting evidence indicates that astrocytes may act as neural stem cells and contribute ...
Multiple Early-Life Seizures Alters Neonatal Communicative Behavior in Fmr1 Knockout Mice [0.03%]
早期多次惊厥会改变弗里克1基因敲除小鼠的新生儿交际行为
Phuoc H Nguyen,David A Narvaiz,Paige D Womble et al.
Phuoc H Nguyen et al.
Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism Spectrum Disorder. Individuals with FXS are subject to developing numerous comorbidities, one of the most prevalent b...
Differential Effects of Urban Particulate Matter on BV2 Microglial-Like and C17.2 Neural Stem/Precursor Cells [0.03%]
城市颗粒物对BV2小胶质细胞样和C17.2神经干细胞/前体细胞的差异效应
Rebecca H Morris,Gwladys Chabrier,Serena J Counsell et al.
Rebecca H Morris et al.
Air pollution affects the majority of the world's population and has been linked to over 7 million premature deaths per year. Exposure to particulate matter (PM) contained within air pollution is associated with cardiovascular, respiratory,...
An Optimized and Detailed Step-by-Step Protocol for the Analysis of Neuronal Morphology in Golgi-Stained Fetal Sheep Brain [0.03%]
一种优化的、详细的高尔基染色胎儿羊脑神经元形态分析的操作流程
Ingrid Dudink,Tegan A White,Maryam Ardalan et al.
Ingrid Dudink et al.
Antenatal brain development during the final trimester of human pregnancy is a time when mature neurons become increasingly complex in morphology, through axonal and dendritic outgrowth, dendritic branching, and synaptogenesis, together wit...
Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury [0.03%]
早产脑损伤成年大鼠步态恢复的幼儿血清素和褪黑素鸡尾酒疗法
Lauren L Jantzie,Sankar Muthukumar,Yuma Kitase et al.
Lauren L Jantzie et al.
Cerebral palsy (CP) is the most common cause of physical disability for children worldwide. Many infants and toddlers are not diagnosed with CP until they fail to achieve obvious motor milestones. Currently, there are no effective pharmacol...
Randomized Controlled Trial
Developmental neuroscience. 2022;44(4-5):266-276. DOI:10.1159/000524394 2022