Progesterone as a Neuroprotective Agent in Neonatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review [0.03%]
孕激素作为新生儿缺氧缺血性脑病神经保护剂的系统评价
Ming-Te Lee,Roisin McNicholas,Lawrence Miall et al.
Ming-Te Lee et al.
Hypoxic-ischaemic encephalopathy (HIE) in the newborn baby is a major contributor to neonatal mortality and morbidity across the world. Therapeutic hypothermia (TH) is the current standard treatment for moderate to severe HIE, but not all b...
Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in Southern China: A Case-Control Study [0.03%]
中国南方脑性瘫痪患者Nogo-A基因多态性的病例对照研究
Yuxin Wang,Lu He,Jingyu Huang et al.
Yuxin Wang et al.
Cerebral palsy (CP) is a motor and postural disorder syndrome caused by the nonprogressive dysfunction of the developing brain. Previous studies strongly indicated that the Nogo-A gene might be related to the pathogenesis of CP. The objecti...
Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder [0.03%]
正字法深度可能会影响阅读障碍儿童在迷宫学习表现的严重程度
Lisa A Gabel,Alexandria Battison,Dongnhu T Truong et al.
Lisa A Gabel et al.
Reading disability (RD), which affects between 5 and 17% of the population worldwide, is the most prevalent form of learning disability, and is associated with underactivation of a universal reading network in children. However, recent rese...
Carvedilol Reduces the Neuronal Apoptosis after Ischemic Stroke by Modulating Activator of Transcription 3 Expression in vitro [0.03%]
卡维地洛通过调节转录激活因子3表达降低缺血性脑卒中后的神经元凋亡：体外研究
Zhao Zheng,Fei Hou,Guodong He et al.
Zhao Zheng et al.
Cerebral ischemia is divided into local cerebral ischemia and diffuse cerebral ischemia. The etiology of localized cerebral ischemia includes middle cerebral artery embolism; stenosis, occlusion, or thrombosis of extracranial internal carot...
Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism [0.03%]
孕期母鼠的压力会诱导后代出现性别依赖的行为变化，并且伴随着受损的血清素和犬尿酸途径的色氨酸代谢路径
Clarissa A Moura,Fernanda C Cagni,Layse R F Costa et al.
Clarissa A Moura et al.
Maternal stress during pregnancy results in increased risk of developing psychiatric disorders in the offspring including anxiety, depression, schizophrenia, and autism. However, the mechanisms underlying this disease susceptibility remain ...
Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development [0.03%]
泛素连接酶Plk4在小鼠脑发育过程中表达分析及其对组织多能干细胞增殖能力的影响研究
Nanako Hamada,Ikuko Iwamoto,Mariko Noda et al.
Nanako Hamada et al.
Polo-like kinase 4 (Plk4) is a ser/thr kinase, which plays a central role in centriole duplication during the cell cycle. PLK4 gene abnormalities are responsible for autosomal recessive chorioretinopathy-microcephaly syndrome and Seckel syn...
Neonatal Anoxia Impacts Rats' Maternal Behavior and Offspring Development due to Ultrasonic Vocalization's Impairment [0.03%]
新生鼠缺氧影响母鼠行为及幼鼠发育由于超声叫声受损所致
Ammir Yacoub Helou,Natalia Andrea Cruz Ochoa,Luciano Freitas Felicio et al.
Ammir Yacoub Helou et al.
Hypoxic-ischemic encephalopathy is a severe clinical condition, among others, affecting the brain after offspring exposure to neonatal anoxia, which causes persistent sensorimotor and cognitive deficits. During peripartum, maternal behavior...
Upregulation of miRNA-26a Enhances the Apoptosis of Cerebral Neurons by Targeting EphA2 and Inhibiting the MAPK Pathway [0.03%]
miRNA-26a上调通过靶向EphA2和抑制MAPK信号通路促进脑神经元凋亡
Bo Chi,Lingjie Deng,Zhifu Zhi et al.
Bo Chi et al.
Neural tube defects (NTDs) constitute the second most common congenital malformation of the central nervous system. The pathogenesis of NTDs is not entirely clear. In recent years, microRNAs (miRNAs) have become a hot spot in genetic and de...
Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats [0.03%]
鼻内给胰岛素减轻新生大鼠高血糖对海马的长期不良影响
Lauren McClure Yauch,Kathleen Ennis-Czerniak,William H Frey Ii et al.
Lauren McClure Yauch et al.
Hyperglycemia due to relative hypoinsulinism is common in extremely preterm infants and is associated with hippocampus-mediated long-term cognitive impairment. In neonatal rats, hypoinsulinemic hyperglycemia leads to oxidative stress, alter...
Randomized Controlled Trial
Developmental neuroscience. 2022;44(6):590-602. DOI:10.1159/000526627 2022
Impact of High Glucose Exposure on Induction of Apoptosis and Its Implication on Developing Retina of Zebrafish Embryos [0.03%]
高血糖诱导斑马鱼胚胎视网膜细胞凋亡及其意义的研究
Suruthi Sankar,Deepika Suresh,Muhammed Ibrahim
Suruthi Sankar
The objective was to study the effects of high glucose on the morphological changes and to observe the expression of apoptosis regulatory proteins in the developing retina in vivo using zebrafish embryos. Wild-type male and female zebrafish...