Characterization of Gene Regulatory Elements in Human Fetal Cortical Development: Enhancing Our Understanding of Neurodevelopmental Disorders and Evolution [0.03%]
人胎儿皮层发育中的基因调控元件的特征分析：增强我们对神经发育障碍和进化方面的理解
Qiuyu Guo,Sarah Wu,Daniel H Geschwind
Qiuyu Guo
The neocortex is the region that most distinguishes human brain from other mammals and primates [Annu Rev Genet. 2021 Nov;55(1):555-81]. Studying the development of human cortex is important in understanding the evolutionary changes occurri...
Out of Line or Altered States? Neural Progenitors as a Target in a Polygenic Neurodevelopmental Disorder [0.03%]
离线还是变异状态？神经前体细胞在多基因神经发育障碍中的靶点作用
Shah Rukh,Daniel W Meechan,Thomas M Maynard et al.
Shah Rukh et al.
The genesis of a mature complement of neurons is thought to require, at least in part, precursor cell lineages in which neural progenitors have distinct identities recognized by exclusive expression of one or a few molecular markers. Nevert...
Hippo Pathway in Schwann Cells and Regeneration of Peripheral Nervous System [0.03%]
少突胶质细胞和雪旺细胞中的组蛋白乳酸化修饰及神经髓鞘形成调控机制研究
Jingyuan Wang,Haofeng Chen,Wulei Hou et al.
Jingyuan Wang et al.
Hippo pathway is an evolutionarily conserved signaling pathway comprising a series of MST/LATS kinase complexes. Its key transcriptional coactivators YAP and TAZ regulate transcription factors such as TEAD family to direct gene expression. ...
Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery [0.03%]
发育性脑损伤及社会健康决定因素：结合前临床模型以获得恢复机制见解的机会
Danielle Guez-Barber,Amelia J Eisch,Ana G Cristancho
Danielle Guez-Barber
Epidemiological studies show that social determinants of health are among the strongest factors associated with developmental outcomes after prenatal and perinatal brain injuries, even when controlling for the severity of the initial injury...
In utero Exposure to Valproic Acid throughout Pregnancy Causes Phenotypes of Autism in Offspring Mice [0.03%]
孕期全程暴露于丙戊酸盐可致后代小鼠表现出自闭症表型
Takayuki Mitsuhashi,Satoko Hattori,Kimino Fujimura et al.
Takayuki Mitsuhashi et al.
Valproic acid (VPA) is an antiepileptic drug that inhibits the epileptic activity of neurons mainly by inhibiting sodium channels and GABA transaminase. VPA is also known to inhibit histone deacetylases, which epigenetically modify the cell...
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation [0.03%]
宫内生长受限后海马性别二态性(postnatal)可塑性关键期的关闭：与少突胶质细胞和胶质异常调节的关系
Michael Nugent,Mark St Pierre,Ashley Brown et al.
Michael Nugent et al.
Intrauterine growth restriction (IUGR) resulting from hypertensive disease of pregnancy (HDP) leads to sexually dimorphic hippocampal-dependent cognitive and memory impairment in humans. In our translationally relevant mouse model of IUGR i...
Prenatal Stress Induces Translational Disruption Associated with Myelination Deficits [0.03%]
孕期应激诱导与髓鞘发育障碍相关的转录组干扰
Gabrielle K Crombie,Hannah K Palliser,Julia C Shaw et al.
Gabrielle K Crombie et al.
Disruptions to neurodevelopment are known to be linked to behavioral disorders in childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter inhibitory GABAergic pathways and critical myelination processes, ...
Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy [0.03%]
树枝状聚谷氨酰胺酶II抑制剂改善兔脑瘫模型小胶质细胞的改变
Nirnath Sah,Zhi Zhang,Alicia Chime et al.
Nirnath Sah et al.
We have previously shown that maternal endotoxin exposure leads to a phenotype of cerebral palsy and pro-inflammatory microglia in the brain in neonatal rabbits. "Activated" microglia overexpress the enzyme glutamate carboxypeptidase II (GC...
A Proposed Human Structural Brain Connectivity Matrix in the Center for Morphometric Analysis Harvard-Oxford Atlas Framework: A Historical Perspective and Future Direction for Enhancing the Precision of Human Structural Connectivity with a Novel Neuroanatomical Typology [0.03%]
人脑结构连接矩阵的提议：基于哈佛-牛津解剖 atlas 的形态计量学中心视角及未来利用新型神经解剖分类提升人类结构连接精度的方向性探索
Nikos Makris,Richard Rushmore,Jonathan Kaiser et al.
Nikos Makris et al.
A complete structural definition of the human nervous system must include delineation of its wiring diagram (e.g., Swanson LW. Brain architecture: understanding the basic plan, 2012). The complete formulation of the human brain circuit diag...
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring [0.03%]
病毒感染模拟物Poly I:C诱导的母体免疫激活对接触小鼠 offspring 少突胶质细胞的影响
Sophia M Loewen,Adriano M Chavesa,Colin J Murray et al.
Sophia M Loewen et al.
Maternal immune activation (MIA) can result from a variety of maternal inflammatory factors, including metabolic disorders, nutritional deficits, infections, and psychosocial stress. MIA has been consistently recognized as a major risk fact...