Neuroprotective Effects of Delayed TGF-β1 Receptor Antagonist Administration on Perinatal Hypoxic-Ischemic Brain Injury [0.03%]
延迟给予TGF-β1受体拮抗剂对围产期缺氧缺血性脑损伤的神经保护作用
Hur Dolunay Kanal,Steven W Levison
Hur Dolunay Kanal
Hypoxic-ischemic (HI) brain injury in neonatal encephalopathy triggers a wave of neuroinflammatory events attributed to causing the progressive degeneration and functional deficits seen weeks after the primary damage. The cellular processes...
Fluoxetine Can Cause Epileptogenesis and Aberrant Neurogenesis in Male Wild-Type Mice [0.03%]
氟西汀可诱发野生型小鼠癫痫发作及异常神经再生
Ksenia Musaelyan,Mark A Horowitz,Stephen McHugh et al.
Ksenia Musaelyan et al.
Antidepressants in general, and fluoxetine in particular, increase adult hippocampal neurogenesis (AHN) in mice. Here we asked how the antidepressant fluoxetine affects behavior and AHN in a corticosterone model of depression. In three grou...
Fetal Origins of Health Disparities: Transgenerational Consequences of Racism [0.03%]
种族歧视的跨世代影响：健康差异的胎儿起源
Nana Matoba,James W Collins,Maria L V Dizon
Nana Matoba
Despite advances in perinatal medicine, racial disparity in birth outcomes remains a public health problem in the USA. The underlying mechanisms for this long-standing racial disparity are incompletely understood. This review presents trans...
Early Gray Matter Structural Covariance Predicts Longitudinal Gain in Arithmetic Ability in Children [0.03%]
儿童早期灰质结构协变可预测其算术能力纵向发展水平提升
Tian Ren,Zheng Li,Chunjie Wang et al.
Tian Ren et al.
Previous neuroimaging studies on arithmetic development have mainly focused on functional activation or functional connectivity between brain regions. It remains largely unknown how brain structures support arithmetic development. The prese...
Meiqian Ma,Jesse Sandberg,Bahare Farhadian et al.
Meiqian Ma et al.
Pediatric acute-onset neuropsychiatric syndrome (PANS), pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections, Sydenham chorea, and other postinfectious psychiatric deteriorations are thought to be caused b...
Blood Biomarkers in the Fetally Growth Restricted and Small for Gestational Age Neonate: Associations with Brain Injury [0.03%]
胎儿生长受限和胎龄小的新生儿中的血液生物标志物与脑损伤的关系
Hannah Musco,Kate Beecher,Kirat K Chand et al.
Hannah Musco et al.
Fetal growth restriction (FGR) and small for gestational age (SGA) infants have increased risk of mortality and morbidity. Although both FGR and SGA infants have low birthweights for gestational age, a diagnosis of FGR also requires assessm...
Does Perinatal Intermittent Hypoxia Affect Cerebrovascular Network Development? [0.03%]
胎间歇性缺氧是否影响脑血管网络发育？
Vanessa Coelho-Santos,Anne-Jolene N Cruz,Andy Y Shih
Vanessa Coelho-Santos
Perinatal hypoxia is an inadequate delivery of oxygen to the fetus in the period immediately before, during, or after the birth process. The most frequent form of hypoxia occurring in human development is chronic intermittent hypoxia (CIH) ...
Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy [0.03%]
弥散磁共振成像的量化在新生儿缺氧缺血性脑病预后评估中的应用研究
Kengo Onda,Raul Chavez-Valdez,Ernest M Graham et al.
Kengo Onda et al.
Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of acquired neonatal brain injury with the risk of developing serious neurological sequelae and death. An accurate and robust prediction of short- and long-term outcomes ma...
Hypothermia Treatment after Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice [0.03%]
谷胱甘肽过氧化物酶-1过度表达的小鼠经缺氧-缺血后诱导低体温治疗
R Ann Sheldon,Christine Windsor,Fuxin Lu et al.
R Ann Sheldon et al.
The developing brain is uniquely susceptible to oxidative stress, and endogenous antioxidant mechanisms are not sufficient to prevent injury from a hypoxic-ischemic challenge. Glutathione peroxidase (GPX1) activity reduces hypoxic-ischemic ...
Pediatric Glioma Models Provide Insights into Tumor Development and Future Therapeutic Strategies [0.03%]
儿童胶质瘤模型为肿瘤发生及未来治疗策略提供思路
Amelia Foss,Manav Pathania
Amelia Foss
In depth study of pediatric gliomas has been hampered due to difficulties in accessing patient tissue and a lack of clinically representative tumor models. Over the last decade, however, profiling of carefully curated cohorts of pediatric t...