The P53N236S Mutation Plays a Regulatory Role in Osteosarcoma Metastasis Via the Cholesterol-Hedgehog Pathway [0.03%]
P53N236S基因突变通过胆固醇- Hedgehog信号通路在骨肉瘤转移中的调控作用
Wang Lulin,Liu Jiawei,Zhang Shuojie et al.
Wang Lulin et al.
Background/aims: Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Although many treatments for osteosarcoma have been explored, the overall survival rate for patients with ...
Exosome-Mediated Mechanisms of Drug Resistance in Lung Cancer: Molecular Mechanisms and Therapeutic Strategies [0.03%]
肺癌耐药的外泌体机制：分子机制和治疗策略
Vita Havryliuk,Karolina Wojtowicz,Maciej Gagat et al.
Vita Havryliuk et al.
Lung cancer, one of the leading causes of cancer-related deaths globally, is notorious for its poor prognosis and limited response to conventional therapies. Despite advancements in chemotherapy, targeted therapies, and immunotherapy, the e...
Effect of Lychee Peel and Seed Flour Consumption on the Anti/Pro-Oxidant System and Cardiomyocyte Contractile Function [0.03%]
荔枝壳核粉对大鼠抗/促氧化系统及心肌细胞收缩功能的影响
Priscila Murucci Coelho,Luísa Martins Simmer,Amanda Rangel Madureira et al.
Priscila Murucci Coelho et al.
Background/aims: Type 2 diabetes mellitus (T2DM) represents a high risk for developing cardiovascular diseases, with alterations in contractile function and calcium (Ca2+) handling. In addition, there is an increase of re...
Thamer A Hamdan
Thamer A Hamdan
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system. Along with their cardinal role in eliminating virally infected and cancerous cells, they are considered as a bridge between innate and adaptive immunity. Nutri...
Negative Impact of Caloric Restriction on Atherosclerosis in Young ApoE/LDLr -/- Mice [0.03%]
限制热卡摄入对年轻ApoE/LDLr双基因敲除小鼠动脉粥样硬化的影响
Renata B Kostogrys,Magdalena Franczyk-Żarów,Artur Gurgul et al.
Renata B Kostogrys et al.
Background/aims: Caloric restriction (CR) has proven to be the most effective dietary intervention for reducing cardiovascular disease (CVD) associated with obesity. Depending on the age of the mice the effect of caloric ...
Dapagliflozin, An SGLT2 Inhibitor, Improves Endothelial Cell Energy Metabolism Through Enhanced Mitochondrial Respiration [0.03%]
达格列净通过增强线粒体呼吸改善内皮细胞能量代谢
Iga Walczak,Alicja Braczko,Aleksandra Paterek et al.
Iga Walczak et al.
Background/aims: Flozins (sodium-glucose cotransporter 2 inhibitors, SGLT2i) are a new class of antidiabetic drugs that reduce cardiovascular mortality and hospitalization rates in heart failure, regardless of type 2 diab...
Combined Effects of Toxic Metals and Oxidative Stress on the Development and Health of Sea Trout (Salmo Trutta L.) [0.03%]
有毒金属和氧化应激对海水虹鳟鱼(Salmo trutta L.)生长发育及健康的影响及其机制研究
Natalia Kurhaluk,Piotr Kamiński,Halina Tkaczenko
Natalia Kurhaluk
Background/aims: Contaminants in the environment pose a considerable threat to biodiversity, ecological balance, and the health of both wildlife and humans, particularly through the transfer of these harmful substances vi...
Methylglyoxal Reshapes Hepatic and Adipose Tissue Metabolism and Increases Viability of Lymphocytes [0.03%]
甲基甘油醛重塑肝和脂肪组织代谢并增加淋巴细胞存活率
Naiara Cristina Lucredi,Lucas Paulo J Saavedra,Silvano Piovan et al.
Naiara Cristina Lucredi et al.
Background/aims: Methylglyoxal (MG) is associated with the development of metabolic disorders that modify the hepatic energetic metabolism in different ways. However, not much is known about the effects of MG on energy me...
Enhancing Cellular Immunity Through Epitope Peptides of SARS-Cov-2 in Individuals with Specific HLA Allele [0.03%]
针对特定HLA等位基因的新冠肺炎(SARS-CoV-2)表位肽以增强细胞免疫反应
Xinliang Huang,Yunyun Wu,Fangliu Yu et al.
Xinliang Huang et al.
Background/aims: This research explores the effectiveness of a new cytotoxic T-cell epitope peptide specific for HLA-A2402 in enhancing cellular immune responses to SARS-CoV-2 infections. HLA molecules play a key role in ...
ACE2 Expression in the Kidneys of Pregnant and Postpartum Rats: Physiological and Pathological Significance During Pregnancy [0.03%]
大鼠孕期和产后肾脏中ACE2的表达：生理与病理意义
Yu Kikuta,Itsuro Kazama
Yu Kikuta
Background/aims: Pregnancy is associated with changes in renal hemodynamics, such as increases in renal blood flow and the glomerular filtration rate (GFR). Angiotensin-converting enzyme 2 (ACE2), a transmembrane glycopro...