Genotype-Phenotype Correlation of Β-Globin Mutations and Hematological Parameters in Iraqi Β-Thalassemia Patients [0.03%]
伊拉克β-地中海贫血患者的基因型表型相关性及血液学参数变化特征分析
Hamsa Ahmed Jasim,Hind Adnan Mohammed,Raghda Al-Omairi
Hamsa Ahmed Jasim
Background/aims: β-Thalassemia is a common hemoglobin disorder distributed worldwide and caused by mutations in the HBB gene that reduce or abolish β-globin chain synthesis, resulting in chronic hemolytic anemia, ineffe...
Macrophage Migration Inhibitory Factor (MIF) as a Central Regulator of Tumor Progression and Immune Evasion [0.03%]
巨噬细胞迁移抑制因子(MIF)作为肿瘤进展和免疫逃逸的核心调节因子
Aygun Aliyarbayova,Yegana Shakaraliyeva,Hagigat Valiyeva et al.
Aygun Aliyarbayova et al.
Macrophage migration inhibitory factor has emerged as a central regulator of tumor progression and immune evasion. Initially identified as an inflammatory cytokine, it is now understood as a multifunctional signaling molecule that integrate...
Adrenaline and Salbutamol Rapidly Exert Mast Cell-Stabilizing Properties in Rat Peritoneal Mast Cells [0.03%]
肾上腺素和沙丁胺醇快速发挥 mast 细胞稳定性能在大鼠腹膜肥大细胞中
Hikaru Honda,Kurumi Sugawara,Kinari Kawamura et al.
Hikaru Honda et al.
Background/aims: Adrenaline is the first-choice drug for the treatment of anaphylaxis. Previous studies have revealed its prophylactic effects on the release of chemical mediators from mast cells. However, adrenaline quic...
Chronic Infection and Cardiac Aging: a New Perspective on Pathogen-Associated Cardiomyopathy [0.03%]
慢性感染与心脏衰老：病原体相关心肌病的新视角
Noah Walsh,Sophia DeCesare,Kavisha Patel et al.
Noah Walsh et al.
Cardiovascular diseases remain the primary driver of global mortality, with advanced age serving the most significant risk factor for their development and progression. Emerging evidence suggests that chronic infections can act as potent ca...
Epistemology of the Origin of Cancer IV: Predisposing Conditions for Metastases [0.03%]
论癌变起源的 epistemology iv：转移的前提条件
Björn L D M Brücher,Ijaz S Jamall
Björn L D M Brücher
Causal therapy has achieved success in the treatment of epithelial tumors, which account for more than 80% of all cancers. Although frequently claimed as breakthroughs, cancer therapy has achieved limited increases in survival of only weeks...
Exploring the Influence of Schisandrin B on Mice with Multiple Myeloma [0.03%]
schisandrin B对小鼠多发性骨髓瘤的影响研究
Anna Li,Hongchao Sheng,Yan Zou et al.
Anna Li et al.
Background/aims: The management of multiple myeloma (MM), a formidable hematological malignancy, continues to pose substantial challenges. Schisandrin B (Sch B), a bioactive compound derived from Traditional Chinese Medic...
Si Dung Chu,Linh Tran Pham,Minh Thi Tran et al.
Si Dung Chu et al.
Background/aims: To present a clinical case of metabolic syndrome (MetS) and to provide a concise pathophysiological overview with emphasis on underlying metabolic and inflammatory mechanisms. ...
Effects of Urolithin A on Mitochondrial Homeostasis Disruption by LPS in C2C12 Myotubes [0.03%]
乌洛通A对LPS诱导的C2C12肌管细胞线粒体稳态紊乱的影响研究
Germán Tapia-Curimil,Mayalen Valero-Breton,Louise Deldicque et al.
Germán Tapia-Curimil et al.
Background/aims: The Toll-like receptor 4 (TLR4) pathway plays a critical role in mediating inflammatory responses and regulates mitochondrial structural adaptations. Urolithin A (UA), a natural compound that induces mito...
Macrophage Migration Inhibitory Factor and Pulmonary Immunity: a Systems Biology Perspective on Its Role in Lung Diseases [0.03%]
巨噬细胞迁移抑制因子与肺部免疫：系统生物学角度下的作用机制及其在肺疾病中的意义
Aliyarbayova Aygun,Hajiyeva Yaqut,Pashayeva Sara et al.
Aliyarbayova Aygun et al.
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that occupies a central regulatory position within pulmonary immune networks, integrating inflammatory signalling, redox control, and immune-stromal communication. Origi...
mTOR Signalling in Neurodegenerative Disorders: Unveiling Key Factors, Mechanistic Insights, and Possible Therapeutic Interventions [0.03%]
神经退行性疾病中mTOR信号通路的关键因素、机制及潜在治疗策略
Niraj Kumar Jha,Payal Chauhan,Mosleh Mohammad Abomughaid et al.
Niraj Kumar Jha et al.
Neurodegenerative diseases (NDDs) are defined by the gradual degeneration of neuronal cells, wherein the accumulation of misfolded proteins can lead to memory impairments, motor dysfunctions, and other deteriorations. Despite the widespread...