Role of NR4A1-Caveolin-1 Axis in the Orchestration of Mitophagy During Macrophage Senescence [0.03%]
NR4A1-Caveolin-1轴在调控巨噬细胞衰老过程中线粒体自噬的作用
Pei Li,Tian Tian,Xiuting Huang
Pei Li
Background/aims: Arteriosclerosis (AS) remains a leading cause of global mortality, with macrophage senescence playing a crucial role in its progression. Senescent macrophages, characterized by oxidative stress and inflam...
Post-Acute COVID-19 Pathophysiology: Cellular Stress Responses, Immune Dysregulation, and Biochemical Signatures in Recovery Phase [0.03%]
急性期后COVID-19的病理生理学：恢复期的细胞应激反应、免疫失调和生化标志物
Inas M Alhudiri,Mahmoud F Gaballa,Fawzi O Ebrahim et al.
Inas M Alhudiri et al.
Background/aims: Post-acute COVID-19 syndrome (PACS) presents with persistent symptoms such as fatigue, dyspnea, and cognitive impairment, even after apparent clinical recovery. Although widely reported, the biological ba...
Drug Development in Abu Dhabi: Advancing Innovation Through Government Support and a Thriving Ecosystem [0.03%]
阿布扎比的药物研发：政府支持和繁荣生态系统推动创新前行
Namir Shaabani,Aleh Ibrahim Saleh,Mohamed Salem Alameri et al.
Namir Shaabani et al.
Drug development is a complex, high-risk, and resource-intensive process, with global challenges such as high costs, regulatory hurdles, and low clinical trial success rates. These obstacles are especially acute for biotech startups and com...
Magnesium and Zinc Dose-Dependently Stabilize Rat Peritoneal Mast Cells and Enhance the Effects of Adrenaline [0.03%]
镁和锌剂量依赖性地稳定大鼠腹膜肥大细胞并增强肾上腺素的作用
Itsuro Kazama,Hiroyuki Sonobe,Junko Shida
Itsuro Kazama
Background/aims: Magnesium and zinc are vital trace elements found in numerous foods and dietary supplements. In addition to their antioxidant, anticancer, antibacterial, and anti-inflammatory effects, clinical research h...
Protein Tyrosine Kinase 2 Circular RNA Promotes Proliferation and Invasion of Bladder Cancer [0.03%]
圆环RNA蛋白酪氨酸激酶2促进膀胱癌的增殖和侵袭
Jingyi Cao,Guangyue Wang,Yan Zhao et al.
Jingyi Cao et al.
Background/aims: Bladder cancer is a type of malignant tumor that disrupts normal urinary function in patients, thereby significantly impacting their quality of life. This disease also imposes a heavy economic burden on b...
High-Fat Diet Induces MASLD and Adipose Tissue Changes in Obesity-Resistant Rats [0.03%]
高脂饮食诱导肥胖抵抗大鼠MASLD及脂肪组织改变
Amanda Rangel Madureira,Vinicius Valois Pereira Martins,Janete Corrêa Cardoso et al.
Amanda Rangel Madureira et al.
Background/aims: Obesity Resistance (OR) is characterized by limited weight gain and reduced fat accumulation despite an obesogenic diet. However, the metabolic risk, particularly regarding Metabolic Dysfunction-Associate...
Novel Roles for Geranylgeranyl Transferase-III (GGTase-III) in Insulin Secretion [0.03%]
牻牛儿基牻牛儿基焦磷酸转移酶-III(GGPT III)在胰岛素分泌中的新作用
Noah F Gleason,Mirabela Hali,Anjaneyulu Kowluru
Noah F Gleason
Background/aims: Post-translational prenylation of G proteins is implicated in physiological insulin secretion. It has been reported recently that GGTase-III participates in the functional regulation of Ykt6, a synaptobre...
Karolina Anna Kozal,Monika Jarosiewicz,Aleksandra Ewa Szustka et al.
Karolina Anna Kozal et al.
Background/aims: Hypoxia-inducible factor isoforms HIF1 and HIF2 are crucial in the hypoxia response but might also support cancer progression, including breast cancer. O-GlcNAcylation, a post-translational modification r...
Inactivation of the Reactive Oxygen Species-Dependent PI3K/Akt/Mtor Signaling Pathway by Phloroglucinol Contributes to Cytotoxicity in Hep3B Human Hepatocellular Carcinoma Cells [0.03%]
phloroglucinol通过灭活活性氧依赖的pi3k / akt / mtor信号途径对肝癌细胞的毒性作用贡献较大
So Young Kim,Hyun Hwangbo,Gi-Young Kim et al.
So Young Kim et al.
Background/aims: Phloroglucinol is a phenolic derivative isolated from brown algae and reportedly has the potential to induce apoptosis in cancer cells, but its mechanism is unclear. This study aimed to elucidate the comp...
Association of IL4 (Rs2243250) Gene Variant and Mycoplasma Pneumoniae Infection with Asthma Susceptibility in an Iraqi Population [0.03%]
白细胞介素4基因多态性及肺炎支原体感染与伊拉克人群哮喘发病关联研究
Sarah Kassab Shandaway Al-Zamali,Shahad Saad Mohammed,Safa Hasan Radhi et al.
Sarah Kassab Shandaway Al-Zamali et al.
Background/aims: Asthma is a multifactorial disease influenced by both genetic and environmental factors. This study aimed to investigate the association between the IL4 gene polymorphism (rs2243250) and asthma susceptibi...