Enhanced ISGylation via USP18 Isopeptidase Inactivation Fails to Mitigate the Inflammatory or Functional Course of Coxsackievirus B3-Induced Myocarditis [0.03%]
USP18异肽酶失活增强ISGylation未能缓解柯萨奇病毒B3诱导的心肌炎的炎症或功能进展
Nicolas Kelm,Meike Kespohl,Sophia Borowski et al.
Nicolas Kelm et al.
Background/aims: The ubiquitin-like protein ISG15 and its covalent conjugation to substrates (ISGylation) represent a critical interferon (IFN)-induced antiviral mechanism. USP18 is an ISG15-specific isopeptidase and a ke...
Migrasomes in Health and Disease: Insights into Mechanisms, Pathogenesis, and Therapeutic Opportunities [0.03%]
迁移体在健康与疾病中的作用：机制、发病机理及治疗机会的最新见解
Lauryn Akeme,Pollyanna Sibanda,Aisling Fitzgerald et al.
Lauryn Akeme et al.
Migrasomes are newly discovered, migration-dependent organelles that mediate the release of cellular contents into the extracellular environment through a process known as migracytosis. Since their identification in 2014, growing evidence h...
Macrophage Migration Inhibitory Factor: Its Multifaceted Role in Inflammation and Immune Regulation Across Organ Systems [0.03%]
趋化因子抑制因子：其在各器官系统中的促炎和免疫调控作用
Aygun Aliyarbayova,Tamilla Sultanova,Samira Yaqubova et al.
Aygun Aliyarbayova et al.
Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine that acts as a central regulator of inflammation and immune responses across diverse organ systems. Functioning upstream in immune activation cascades, MIF influences ma...
Knockdown of UBD Ameliorates Experimental Rheumatoid Arthritis by Suppressing TLR4/Myd88/NF-κB and P38/MAPK Pathway [0.03%]
UBD基因干扰抑制TLR4/Myd88/NF-κB和P38/MAPK信号通路从而改善实验性类风湿关节炎
Hong Chen,Sha Liu,Yu Zhang et al.
Hong Chen et al.
Background/aims: Ubiquitin D (UBD), a member of the ubiquitin-like modifier (UBL) family, is significantly overexpressed in various cancers and is positively correlated with tumor progression. However, the role and underl...
Co-Immobilization of Trypsin and Lysine -α- Oxidase For the Quantification of Lysine in Casein Hydrolysate. Evaluation with a Biosensor [0.03%]
用于酪蛋白水解物中赖氨酸定量的胰蛋白酶和赖氨酰氧化酶的共固定化研究及生物传感器评估
Christian M Villavicencio Yanos,María Janina Cedeño Vivas,Grether Lucía Real Pérez et al.
Christian M Villavicencio Yanos et al.
Background/aims: The quantification of amino acids in the dairy industry is necessary for quality control and for the formulation of functional foods. Thus, the development of enzymatic biosensors requires a detailed stud...
Non-Enzymatic Antioxidant Defense and Polymorphic Changes in Male Infertility [0.03%]
非酶抗氧化防御与男性不育的多态性变化
Jędrzej Baszyński,Piotr Kamiński,Marek Szymański et al.
Jędrzej Baszyński et al.
Background/aims: Male infertility is conditioned in up to 25% genetically, but environmental factors are equally important. Dependencies analyzed here in this area have not been studied using such an approach so far. Ther...
Editorial: Therapeutic Frontiers and Physiological Impacts of Oxidative Stress Across Biological Systems [0.03%]
editorial: 生物系统中氧化应激的治疗前景及其生理影响
Natalia Kurhaluk
Natalia Kurhaluk
Role of Gut Microbiota in Modulating Oxidative Stress Induced by Environmental Factors [0.03%]
环境因素诱导的氧化应激与肠道菌群的关系研究进展
Natalia Kurhaluk,Piotr Kamiński,Halina Tkaczenko
Natalia Kurhaluk
The widespread presence of environmental pollutants, including toxic metals, microplastics, and antibiotics, has significantly altered gut microbiota composition and functionality, leading to dysbiosis and oxidative stress. These changes co...
Natalia Kurhaluk,Piotr Kamiński,Halina Tkaczenko
Natalia Kurhaluk
It is imperative to comprehend the multifactorial causes of male infertility and to identify effective treatment methods, to enhance male reproductive health, and to develop more personalised and effective therapeutic interventions. This re...
Regulation of αKlotho [0.03%]
αKlotho的调节
Julia Vogt,Michael Föller
Julia Vogt
Since its discovery in 1997, αKlotho has gained a lot of attention due to its powerful anti-aging and health-promoting properties. It exists as a membrane-bound protein or as a soluble factor. Membrane-bound αKlotho is an essential cofact...