Calcium Supplementation Enhanced Adipogenesis and Improved Glucose Homeostasis Through Activation of Camkii and PI3K/Akt Signaling Pathway in Porcine Bone Marrow Mesenchymal Stem Cells (pBMSCs) and Mice Fed High Fat Diet (HFD) [0.03%]
钙补充通过激活猪骨髓间充质干细胞和高脂饮食小鼠的Camkii和PI3K / Akt信号途径来增强成脂作用并改善葡萄糖稳态
Fenglin Zhang,Jingjing Ye,Yingying Meng et al.
Fenglin Zhang et al.
Background/aims: It has been implicated that calcium supplementation is involved in reducing body weight/fat and improving glucose homeostasis. However, the underlying mechanisms are still not fully understood. Here, we i...
Long Non-Coding RNA MALAT1 Protects Human Osteoblasts from Dexamethasone-Induced Injury via Activation of PPM1E-AMPK Signaling [0.03%]
长非编码RNAMALAT1通过激活PPM1E-AMPK信号保护人成骨细胞免受地塞米松诱导的损伤
Jian-Bo Fan,Yingzi Zhang,Wei Liu et al.
Jian-Bo Fan et al.
Background/aims: Dexamethasone (Dex) induces injuries to human osteoblasts. In this study, we tested the potential role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Lnc-MALAT1) in thi...
Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3 [0.03%]
microRNA-124通过靶向STAT3减少心肌梗死后的心肌细胞凋亡
Fang He,Huibin Liu,Jing Guo et al.
Fang He et al.
Background/aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation and apopto...
Novel Zinc Finger Transcription Factor ZFP580 Facilitates All-Trans Retinoic Acid -Induced Vascular Smooth Muscle Cells Differentiation by Rarα-Mediated PI3K/Akt and ERK Signaling [0.03%]
新颖的锌指转录因子ZFP580通过Rarα介导的PI3K/AKT和ERK信号促进全反式维甲酸诱导的血管平滑肌细胞分化
Shuping Wei,Jingjing Zhang,Biao Han et al.
Shuping Wei et al.
Background/aims: Phenotypic switching of vascular smooth muscle cells (VSMC) plays a vital role in the development of vascular diseases. All-trans retinoic acid (ATRA) is known to regulate VSMC phenotypes. However, the un...
Microarray Profiling of TGF-β1-Induced Long Non-Coding RNA Expression Patterns in Human Lung Bronchial Epithelial BEAS-2B Cells [0.03%]
转化生长因子-β1诱导的人肺支气管上皮细胞BEAS-2B芯片长链非编码RNA表达谱分析
Wentao Hu,Weiwei Pei,Lin Zhu et al.
Wentao Hu et al.
Background/aims: TGF-β1 mediated radiation-induced bystander effects (RIBE) have been linked with malignant transformation and tumorigenesis. However, the underlying mechanisms are not fully understood. ...
Genome-Wide Analysis of mRNAs and lncRNAs of Intramuscular Fat Related to Lipid Metabolism in Two Pig Breeds [0.03%]
两个猪品种肌内脂肪相关的脂质代谢mRNA和lncRNA的全基因组分析
Wanlong Huang,Xiuxiu Zhang,Ai Li et al.
Wanlong Huang et al.
Background/aims: Long non-coding RNAs (lncRNAs) can regulate adipogenesis and lipid accumulation. Intramuscular fat deposition appears to vary in different pig breeds, and the regulation mechanism has not yet been fully e...
Ca2+ Signaling Triggered by Shear-Autocrine P2X Receptor Pathway in Rat Atrial Myocytes [0.03%]
剪切力诱导大鼠心房肌细胞自分泌P2X受体钙信号转导机制研究
Joon-Chul Kim,Min-Jeong Son,Sun-Hee Woo
Joon-Chul Kim
Background/aims: The atrium is exposed to high shear stress during heart failure and valvular diseases. We aimed to understand atrial shear-induced Ca2+ signaling and its underlying mechanisms. ...
miR-423-5p Inhibits Osteosarcoma Proliferation and Invasion Through Directly Targeting STMN1 [0.03%]
微RNA-423-5p通过直接靶向STMN1抑制成骨细胞的增殖和浸润
Xuesong Wang,Lei Peng,Xiaojin Gong et al.
Xuesong Wang et al.
Background/aims: Increasing evidences suggest that dysregulated expression of miRNAs contributes to the progression of various tumors. However, the underlying function of miR-423-5p in osteosarcoma remains unexplored. ...
Effects of Triple-Mutated Hypoxia-Inducible Factor-1α on Angiogenesis and Cardiac Function Improvement in Rats with Myocardial Infarction [0.03%]
三突变型缺氧诱导因子-1α对心肌梗死模型大鼠促血管生成及改善心脏功能的影响
Mingyan Li,Yongsheng Cui,Wenkai He et al.
Mingyan Li et al.
Background/aims: The effects of hypoxia-inducible factor-1α (HIF-1α) on angiogenesis and cardiac function improvement in rats with myocardial infarction (MI) is unknown and our current study was to evaluate whether HIF-...
MicroRNA-200a Affects the Proliferation of Airway Smooth Muscle Cells and Airway Remodeling by Targeting FOXC1 via the PI3K/AKT Signaling Pathway in Ovalbumin-Induced Asthmatic Mice [0.03%]
miR-200a通过靶向FOXC1作用于PI3K/AKT信号通路影响卵清蛋白致敏小鼠气道平滑肌细胞增殖及气道重塑
Ying Liu,Yi Miao,Xin Gao et al.
Ying Liu et al.
Background/aims: The etiology of asthma, which is a complicated disorder with various symptoms, including wheezing, coughing, and airflow obstruction, remains poorly understood. In addition, the effects of microRNAs (miRs...