Cav-1 deficiency induces cardiac dysfunction via the AdipoR1-AMPK-mTOR autophagy pathway [0.03%]
Caveolin-1缺乏通过AdipoR1-AMPK-mTOR自噬途径诱导心脏功能障碍
Ziyu An,Libo Liu,Xin Zhao et al.
Ziyu An et al.
Objective and design: This study aimed to investigate the mechanism by which Caveolin-1 (Cav-1) deficiency leads to cardiac dysfunction, utilizing both in vivo and in vitro experimental models. ...
Differential clinical factors influencing the effectiveness of distinct biologic agents in psoriasis: insights from a prospective cohort study in China [0.03%]
中国特应性皮炎患者生物制剂疗效影响因素研究：一项前瞻性队列研究
Min Dai,Yuxiong Jiang,Yuanyuan Wang et al.
Min Dai et al.
Objective and design: This prospective multicenter cohort study was conducted to identify and compare clinical factors associated with the effectiveness of commonly used biologics in Chinese patients with moderate-to-seve...
Intestinal epithelial AhR deletion aggravates DSS-induced colitis via lipid- and amino-acid metabolic reprogramming: integrated metabolomic-transcriptomic evidence [0.03%]
肠道上皮AhR缺失通过脂质和氨基酸代谢重组加剧DSS诱导的结肠炎：整合型代谢组学-转录组学证据
Yuanling Zhang,Fengda Liu,Chao Xu et al.
Yuanling Zhang et al.
Background: Recent studies reveal that the interaction of Aryl Hydrocarbon Receptor (AhR) signaling activation with metabolic homeostasis may significantly affect the course of IBD, and the inhibition of AhR signaling may...
Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle [0.03%]
自噬蛋白ATG13的基因耗竭影响线粒体能量代谢、增强氧化应激，使巨噬细胞极化为M1炎症模式，并损害骨骼肌中的髓鞘完整性
Mubaraq A Toriola,Emma Timlin,Sarojini Bulbule et al.
Mubaraq A Toriola et al.
Objective: M1 macrophage activation is crucial in chronic inflammatory diseases, yet its molecular mechanism is unclear. Results: Our s...
Inhibiting METTL3 in macrophages alleviates colitis by enhancing M2 polarization via upregulating IRAKM [0.03%]
通过上调IRAKM促进M2极化从而缓解结肠炎：抑制巨噬细胞中METTL3的作用
Yang Zhang,Xin Wang,Shan Cao et al.
Yang Zhang et al.
Objective and design: N6-methyladenosine (m6A), the most prevalent RNA modification, plays a crucial role in regulating macrophage homeostasis and intestinal immunity, although its mechanism remains largely unknown. A lin...
Nanozyme-based therapies for inflammatory immune disorders: opportunities and challenges [0.03%]
基于纳米酶的治疗炎症免疫疾病的机遇与挑战
Wenqian Zhang,Shaozhe Cai,Jiayi Ma et al.
Wenqian Zhang et al.
Background: Immune-mediated inflammatory diseases (IMIDs) are chronic disorders involving multiple organs and driven by shared pathogenic pathways. Current therapeutic approaches, such as disease-modifying anti-rheumatic ...
S100A8 aggravates sepsis-associated encephalopathy by promoting PFKFB3-dependent glycolysis and microglial neuroinflammation [0.03%]
S100A8通过促进PFKFB3依赖性糖酵解和小胶质细胞神经炎症加剧脓毒症相关性脑病
Hongjie Hu,Shu Peng,Jingbo Chen et al.
Hongjie Hu et al.
Background: Sepsis-associated encephalopathy (SAE) is a common and severe neurological complication of sepsis that markedly worsens long-term outcomes. Growing evidence suggest that metabolic reprogramming in microglia is...
Recombinant TsP53 mitigates inflammation and blood-brain barrier disruption in CLP-induced septic mice [0.03%]
重组TsP53可通过减轻CLP诱导的脓毒症小鼠脑组织炎症和血脑屏障破坏而发挥神经保护作用
Deng Zhezhi,Sun Zaiyuan,Lu Gengxin et al.
Deng Zhezhi et al.
Background: Sepsis-associated encephalopathy (SAE), a neurological complication of sepsis without direct CNS infection, currently lacks established pharmacological therapy. Key pathological features include excessive micr...
Longitudinal biomarker trajectories and their prognostic utility for 21-day mortality in burn patients with sepsis: a retrospective cohort study [0.03%]
烧伤伴发脓毒症患者生物标志物纵向轨迹及其对21天死亡率的预后价值：一项回顾性队列研究
Jiaqi Lou,Hong Kong,Jiliang Li et al.
Jiaqi Lou et al.
Objective: To characterize the longitudinal trajectories of multi-category biomarkers and evaluate their association with 21-day all-cause mortality in critically ill burn patients with sepsis. ...
Erianin protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by activating GPX4/STING signaling in osteoarthritis [0.03%]
埃里喃通过激活GPX4/STING信号通路保护软骨细胞免受IL-1β诱导的氧化应激和铁死亡在骨关节炎中的作用研究
Cuiyu Li,Wei Jian,Shuai Lu et al.
Cuiyu Li et al.
Background: Erianin (Eri) has been known for its analgesic and antipyretic properties. This research focuses on impact of Eri on chondrocyte viability, inflammatory cytokine production, extracellular matrix (ECM) degradat...