Integrated multi-omics profiling reveals the potential role of maternal systemic immune dysregulation driven by monocyte/macrophage in preeclampsia [0.03%]
整合多组学谱型揭示了妊娠期单核细胞/巨噬细胞介导的母体系统性免疫异常在子痫前期发病中的潜在作用
Xiaolei Yuan,Kexin Han,Xiaolu Zhan et al.
Xiaolei Yuan et al.
Glucocorticoids combined with anticoagulation modulate the central NLRP3/NETosis inflammatory process in patients with severe cerebral venous thrombosis: a human mechanistic exploratory study [0.03%]
糖皮质激素联合抗凝通过调节严重脑静脉窦血栓形成患者中央NLRP3/NETosis炎症过程促进神经功能恢复：一项人机制探索性研究
Yu Li,Chao Ying,Xuemin Wang et al.
Yu Li et al.
Objectives: Neutrophil-mediated neuroinflammation plays a crucial role in secondary brain injury following severe cerebral venous thrombosis (CVT). Although previous studies have reported that the combination of glucocort...
Regulated cell death in sepsis: reframing NETosis within the spectrum of apoptosis and inflammatory lytic death [0.03%]
脓毒症中的细胞程序性死亡：在凋亡和炎症裂解性死亡谱系中重新定义NETosis
Toshiaki Iba,Hideshi Okada,Isao Nagaoka et al.
Toshiaki Iba et al.
Background: Sepsis is characterized by dysregulated inflammation leading to organ dysfunction. While immune activation and metabolic stress are central features, accumulating evidence suggests that regulated cell death pr...
The ubiquitin ligase FBXW7 regulates epithelial pyroptosis in severe asthma [0.03%]
泛素连接酶FBXW7通过调节上皮细胞焦亡抑制重度哮喘小鼠的气道炎症及重塑
Yixia Jiang,Tingfen Ji,Xuezhu Ren et al.
Yixia Jiang et al.
Background: Severe asthma is characterized by persistent airway inflammation and epithelial injury. Pyroptosis, a Caspase-1-dependent inflammatory cell death pathway, has been implicated in airway inflammation. FBXW7, an ...
The role of neutrophils in the pathogenesis of abdominal aortic aneurysms [0.03%]
中性粒细胞在腹主动脉瘤发病机制中的作用
Stephen A Addo,Kamila Wojnar-Lason,Amritha Sreekumar et al.
Stephen A Addo et al.
Background: Abdominal aortic aneurysm (AAA) is a progressive degenerative vascular disease characterized by structural weakening and pathological dilatation of the abdominal aortic wall. Currently, no effective pharmacolo...
Renin-angiotensin imbalance promotes excessive fibrin deposition through M2 macrophage-derived tissue factor expression in eosinophilic chronic rhinosinusitis [0.03%]
肾素血管紧张素平衡紊乱通过M2型巨噬细胞衍生的组织因子表达促进嗜酸细胞性慢性鼻窦炎中过量纤维蛋白沉积
Tetsuji Takabayashi,Kanako Yoshida,Yukinori Kato et al.
Tetsuji Takabayashi et al.
Background: Recalcitrant nasal polyps are hallmarks of eosinophilic chronic rhinosinusitis, with abnormal fibrin deposition being critical for nasal polyp development. However, the specific cellular and molecular mechanis...
Lp-PLA2-derived LysoPC drives dendritic cell immunogenic activation and Th17 inflammation in severe asthma [0.03%]
严重哮喘中Lp-PLA2衍生的LysoPC驱动树突状细胞免疫激活和Th17炎症反应
Fang Wang,Zhihui Min,Yuhao Qian et al.
Fang Wang et al.
Severe asthma (SA) is associated with dysregulated phospholipid metabolism, yet the underlying immunometabolic mechanisms remain poorly understood. Our metabolomic profiling of SA patients revealed a characteristic remodeling of the phospha...
Mechanistic insights into natural product-driven modulation of NLRP3-inflammasome signalling in metabolic syndrome [0.03%]
代谢综合征中天然产物驱动的NLRP3炎性体信号转导调节机制的新见解
Prastuti Sahariah,Lunasmrita Saikia,Albert Bharali et al.
Prastuti Sahariah et al.
Introduction: Metabolic syndrome (MetS) comprises a cluster of interrelated metabolic abnormalities, including obesity, insulin resistance, dyslipidaemia and hypertension, mainly driven by chronic low-grade inflammation. ...
Targeting angiopoietin-like protein 3 and interleukin-1β alleviated liver and kidney injury through attenuation of lipotoxicity and regulation of glycolipid metabolism in db/db mice [0.03%]
靶向血管生成素样蛋白3和白细胞介素-1β通过减缓脂毒性及调节糖脂代谢缓解db/db小鼠肝肾损伤
Shuwen Xu,Longfei Wang,Zihan Dou et al.
Shuwen Xu et al.
Objective: Concomitant liver and kidney injury is a critical pathological feature of metabolic disorders, but current organ-specific therapies often fail to provide cross-protection. Lipotoxicity is a core mechanism linki...
Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells [0.03%]
ITIH4高表达的巨噬细胞可减轻炎症反应并调控肠上皮细胞功能
Jing Li,Zhuoqi Zhao,Jun Fei et al.
Jing Li et al.
Objective: Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an acute phage protein and secretory protein that is highly related to inflammation. However, the expression profile and function of ITIH4 in macrophage-me...