Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface [0.03%]
将胎盘绒毛膜羊膜炎重新定义为母胎界面的免疫介导性炎症性疾病
Tzu-Ming Wang,Chung-Min Shen,Shih-Chang Lin et al.
Tzu-Ming Wang et al.
Background: Chorioamnionitis has long been regarded as an infection-driven obstetric disorder, yet converging clinical, pathological, and mechanistic evidence demonstrates that host-derived inflammatory pathways, together...
Endoglin is not a mediator in 7-ketocholesterol-induced endothelial activation in liver sinusoidal endothelial cells in vitro [0.03%]
内皮细胞活化在体外肝窦状内皮细胞中并非7-酮基胆固醇诱发的内皮蛋白(endoglin)的介质
Petra Fikrova,Katarina Tripska,Samira Eissazadeh et al.
Petra Fikrova et al.
Background: Endoglin (ENG) is expressed in liver sinusoidal endothelial cells (LSECs), where it regulates endothelial activation and inflammation. The 7-ketocholesterol (7-K), a cholesterol oxidation product, accumulates ...
Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury [0.03%]
甲基丙二酸作为铁死亡衍生的危险信号：PI3K-NF-κB通路的激活驱动了肾缺血再灌注损伤中的M1型巨噬细胞极化
Huimeng Wang,Jiajia Sun,Xiaohu Li et al.
Huimeng Wang et al.
Background: Ferroptosis and macrophage activation are key contributors to the development of acute kidney injury (AKI). Ferroptosis is accompanied by metabolic reprogramming and the release of soluble mediators, including...
Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies [0.03%]
糖尿病中的缺陷性凋亡细胞清除作用：分子机制和新兴治疗策略
Yanqi Lei,Min Tang,Huilan Deng et al.
Yanqi Lei et al.
Background: Diabetes is associated with oxidative stress, systemic immune dysregulation and chronic low-grade inflammation, which contributes to a wide spectrum of microvascular and macrovascular complications. Efferocyto...
Extracellular vesicle-mediated mechanisms and therapeutic potential in acute lung injury [0.03%]
急性肺损伤中外泌体介导的机制及其治疗潜力
Yulan Song,Xiaoqian Zhang,Dan Wang et al.
Yulan Song et al.
Background: Acute lung injury (ALI) is a severe inflammatory lung disorder characterized by disruption of the alveolar-capillary barrier and impaired gas exchange, often progressing to acute respiratory distress syndrome ...
Lactylation: a novel post-translational modification for cGAS-STING pathway [0.03%]
乳酰化：一种新的cGAS-STING通路的翻译后修饰机制
Hongquan Wang,Zhiji Wang,Fanyu Meng et al.
Hongquan Wang et al.
Background: Lysine lactylation (Kla) is a lactate-derived post-translational modification that has emerged as a critical metabolic-epigenetic regulator linking cellular metabolic states to innate immune signaling. The cGA...
Transcriptomics and metabolomics reveal the protective effect of β-hydroxybutyrate on sepsis associated encephalopathy [0.03%]
转录组学和代谢组学揭示了β-羟基丁酸对脓毒症相关性脑病的保护作用
Jin-Wei Liang,Yan Chen,Chu-Yun Liu et al.
Jin-Wei Liang et al.
Background: In this study, metabolomics and transcriptomics were applied to reveal the potential mechanisms underlying the protective effects of β-hydroxybutyrate (BHB) on sepsis-associated encephalopathy (SAE). ...
WNT4 reprograms dental pulp stem cells to resist PANoptosis and rebuild neurogenic potential for facial nerve injury repair [0.03%]
WNT4重编程牙髓干细胞以抵抗PANoptosis并重建神经潜能以修复面部神经损伤
Wanqiu Xu,Hualei Xi,Song Lin et al.
Wanqiu Xu et al.
Objective and design: This study investigated the protective role and molecular mechanism of WNT4 in preserving the viability and neurogenic potential of dental pulp stem cells (DPSCs) within an inflammatory microenvironm...
SARS-CoV-2 drives upregulation of EpCAM in respiratory epithelial cells with hypercellular profile during severe COVID-19 [0.03%]
SARS-CoV-2在严重COVID-19期间驱动呼吸道上皮细胞增生过程中EpCAM的上调表达
Franklin Pereira Araújo,Geovane Marques-Ferreira,Camila Pacheco Silveira Martins da Mata et al.
Franklin Pereira Araújo et al.
Background: At the end of 2019, severe acute respiratory syndrome (SARS) caused by the novel coronavirus SARS-CoV-2 emerged in China, representing one of the most significant global health threats of the twenty-first cent...
ERK1/2 activation in anti-inflammatory effects and underlying signaling mechanisms [0.03%]
ERK1/2活化介导的抗炎效应及其信号机制研究
Kaiwen Tao,Lin Xu,Chao Cheng et al.
Kaiwen Tao et al.
Introduction: ERK1/2 are core components of the MAPK signaling pathway and play a central role in the regulation of inflammation. Although ERK1/2 activation is well established for driving pro-inflammatory responses, accu...