Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps [0.03%]
炎症中的溶血磷脂酸信号的上下文依赖性：证据等级、髓样细胞调控和转化缺口
Wataru Nagata,Kunio Takada
Wataru Nagata
Background: Lysophosphatidic acid (LPA) has been extensively reviewed in receptor pharmacology, fibrosis, cancer, vascular biology and neural injury. Its role in inflammation remains difficult to interpret because well-re...
MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren's syndrome [0.03%]
MICA基因在弥漫性大B细胞淋巴瘤和原发性干燥综合征中的作用及机制研究
Hancheng Qin,Kuai Yu,Xuefei Deng et al.
Hancheng Qin et al.
Objective: To identify shared molecular mechanisms and crosstalk genes (CGs) between diffuse large B-cell lymphoma (DLBCL) and primary Sjögren's syndrome (PSS), and to explore the role of MICA in the immune microenvironm...
NKR+CD8+ T cells and iNKT cells protect mice from AOM/DSS-induced colorectal cancer under conditions of IFNγ-mediated hyperinflammation [0.03%]
干扰素-γ介导的过度炎症条件下，NKR+CD8+T细胞和iNKT细胞保护小鼠免受AOM/DSS诱导的结直肠癌的影响
Hyun Jung Park,Sung Won Lee,Yun Hoo Park et al.
Hyun Jung Park et al.
Background: Interferon-gamma (IFNγ) is a pivotal cytokine in immune surveillance and inflammation, yet its precise role in colorectal cancer (CRC) remains controversial due to its dual involvement in tumor suppression an...
TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury [0.03%]
内毒素诱导的急性肺损伤中肺微血管内皮通透性增加与内皮细胞pyroptosis有关且依赖于TRPV4/IP3R-1通道蛋白复合体
Shasha Liu,Shuan Dong,Lirong Gong et al.
Shasha Liu et al.
Background: Sepsis-induced acute lung injury (ALI) is characterized by edema resulting from increased vascular permeability. Transient receptor potential vanilloid 4 (TRPV4) interacts with inositol 1,4,5-trisphosphate rec...
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects [0.03%]
肠道细菌外泌体对血管生成潜能和血管完整性的影响：正反两面
Sara Aghakhani Chegeni,Banafsheh Yalameha,Somayyeh Rashidi et al.
Sara Aghakhani Chegeni et al.
Extracellular vesicles (EVs) are intercellular mediators in prokaryotic and eukaryotic systems that have the potential to regulate various physiological and pathological processes in recipient cells. Among them, bacterial extracellular vesi...
International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study [0.03%]
使用床旁流式细胞仪进行严重创伤后中性粒细胞表面标记的国际比较是可行的：一项初步研究的结果
Christian Thomas Hübner,Emma de Fraiture,Nathalie Piaz et al.
Christian Thomas Hübner et al.
Introduction: The dynamics of cell surface marker expression on systemic neutrophils provide valuable insights into the post-traumatic immune response. Recent advances in point-of-care (PoC) technologies allow for rapid o...
Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease [0.03%]
炎症性肠病中树突状细胞法尼醇X受体调控Tphp细胞分化
Zhen Hu,Minya Liu,Chengkai Zhu et al.
Zhen Hu et al.
Background: Peripheral helper T cells represent a recently characterized subset of CD4+ T cells present in inflammatory bowel disease (IBD) patients. Bile acids act as signaling molecules in immune regulation. However, th...
SERPINE1 in ARDS: an emerging regulator of inflammation-coagulation-fibrinolysis crosstalk [0.03%]
肺损伤中SERPINE1：炎症-凝血-纤溶信号转导的新兴调控因子
Nan Gao,Song Yang,Wei-Jian Zhang et al.
Nan Gao et al.
Objective and design: This narrative review synthesizes current evidence on the role of SERPINE1/PAI-1 in acute respiratory distress syndrome (ARDS), with particular emphasis on inflammation-coagulation-fibrinolysis cross...
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease [0.03%]
A20锌指7等位基因变异与自身免疫性疾病相关
Mohamed Alsabbagh,Satanay Z Hubrack,Lara Gamgoum et al.
Mohamed Alsabbagh et al.
Background: A20 is an anti-inflammatory protein that suppresses nuclear factor-κB (NF-κB)-mediated inflammatory gene expression and inhibits cell death. Disruption of A20 function results in defective suppression of the...
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production [0.03%]
尼氟amic酸通过限制氯离子释放和线粒体ROS生成来抑制NLRP3炎性小体活化
Yuanhao Li,Qianqian Xie,Tianyin Sun et al.
Yuanhao Li et al.
Background and aims: Aberrant activation of the NLRP3 inflammasome contributes to the development of multiple inflammatory disorders, but clinically approved inhibitors targeting this pathway are still lacking. We investi...