A 62-aa core of the cochlin LCCL domain induces macrophage M1 polarization in vitro [0.03%]
一个62个氨基酸的CochlinLCCL结构域核心片段可在体外诱导巨噬细胞向M1方向极化
Hyoyeol Kim,Seong Hoon Bae,Seung Hyun Jang et al.
Hyoyeol Kim et al.
Background: Cochlin, encoded by the COCH gene, mediates innate immunity against bacterial infections by segregating pathogens and recruiting immune cells through its N-terminal LCCL domain. This domain is cleaved and secr...
Host immune dysfunction and Mycoplasma pneumoniae immune evasion: dual drivers of pathogenesis in Mycoplasma pneumoniae pneumonia [0.03%]
宿主免疫功能障碍和肺炎支原体免疫逃避：肺炎支原体肺炎发病机制的双重驱动因素
Hanxue Xiang,Caopei Zheng,Yu Wang et al.
Hanxue Xiang et al.
Diagnostic significance of salivary and glandular siglec-5 in Sjögren disease and non-Sjögren sicca [0.03%]
Salivary和腺泡Siglec-5在干燥综合征及非干燥综合征唾液减少症的诊断意义
Fernanda Luiza Araújo de Lima Castro,Laiz Fernandes Mendes Nunes,Fernanda Aragão Felix et al.
Fernanda Luiza Araújo de Lima Castro et al.
Background: Sjögren disease (SjD) has a multifactorial pathogenesis that is not fully understood. Perceptions of disease severity shape healthcare-seeking behavior and engagement with diagnostic assessments, underscoring...
Advances in the lectin pathway in systemic lupus erythematosus: from clinical correlations and mechanisms to targeted interventions [0.03%]
补体凝集素途径在系统性红斑狼疮中的进展：从临床相关性和机制到靶向干预
Rongfang Feng,Yufei Zhang,Qin Chen et al.
Rongfang Feng et al.
Background: The complement system critically mediates systemic lupus erythematosus (SLE) pathogenesis through dual mechanisms: promoting inflammatory organ damage while regulating the initiation of immune tolerance. Among...
FBXO6 mediated ubiquitination of SLC3A2 drives ferroptosis in ulcerative colitis: a machine learning and SHAP discovery [0.03%]
基于机器学习和SHAP算法发现的溃疡性结肠炎中FBXO6介导的SLC3A2泛素化驱动铁死亡
Longfei Dai,Chao Yu,Ronglin Xu et al.
Longfei Dai et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease characterized by mucosal immune activation and epithelial barrier breakdown. The pathogenic mechanisms underlying UC remain incompletely understood, an...
Thrombosis-related gene signature predicts prostate cancer recurrence and immune therapy: insights from retrospective cohorts, bioinformatics, and experimental validation [0.03%]
血栓相关基因谱预测前列腺癌复发和免疫治疗：来自回顾性队列、生物信息学及实验验证的启示
Yong Luo,Peixian Chen,Minyi Situ et al.
Yong Luo et al.
Background: Thrombosis was recognized as a significant cause of morbidity and mortality for prostate cancer (PCa). The potential mechanisms underlying the effect of thrombosis on PCa remain elusive. ...
Precision medicine in sepsis: reappraising glucocorticoid therapy through the lens of molecular endotypes [0.03%]
精准治疗在感染性休克：通过分子分型再评价糖皮质激素疗法的效果
Jiaqi Li,Yuqin Zhang,Fan Jiang et al.
Jiaqi Li et al.
Sepsis is a life-threatening organ dysfunction syndrome with high mortality. Due to the heterogeneity of its clinical manifestations and treatment responses, it has long faced great challenges in clinical management. In recent years, the pr...
PINK1 deacetylation by emodin-induced SIRT3 upregulation alleviates acute kidney injury by Inhibition of ferroptosis [0.03%]
大黄素诱导的SIRT3上调介导PINK1去乙酰化抑制铁死亡从而改善急性肾损伤
Rui Wang,Ziwei Zou,Yi An et al.
Rui Wang et al.
Background: Acute kidney injury (AKI), characterized by rapid renal dysfunction and high mortality, is critically driven by ferroptosis, an iron-dependent form of cell death. While PTEN-induced kinase 1 (PINK1) and sirtui...
Delayed disulfiram targeting GSDMD-NETs axis rescues sepsis by limiting bacterial spread and lung injury [0.03%]
延缓二硫化四胺靶向GSDMD-NETs轴通过限制细菌扩散和肺损伤救治脓毒症
Xiaoxi Shan,Zhishu Li,Lixia Dong
Xiaoxi Shan
Background: Sepsis therapy faces a critical paradox: Gasdermin D (GSDMD)-mediated neutrophil extracellular traps (NETs) exert protective host defense early but drive tissue injury late. Defining the temporal dynamics of i...
Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis [0.03%]
二十二碳六烯酸补充抑制脓毒症中的单核细胞耗竭记忆形成
Blake A Caldwell,Yajun Wu,Susanti Ie et al.
Blake A Caldwell et al.
Objective and design: Docosahexaenoic acid (DHA) is an omega-3 fatty acid with important roles in inflammation resolution. We tested the impact of DHA supplementation on monocyte exhaustion, an immune memory state contrib...