Multi-omics profiling reveals EMT-driven fibroblast activation in the renal injury niche [0.03%]
多组学谱分析揭示肾损伤微环境中的上皮间质转化诱导的成纤维细胞活化
Songmei Zhai,Keru Li,Kaidong Liu et al.
Songmei Zhai et al.
Persistent renal injury creates conditions for activating fibroblasts. However, due to the complexity of the renal injury microenvironment, the mechanisms driving fibroblast activation remain poorly understood. Here, we use single-nucleus R...
Breed-specific divergence in boar sperm regulatory profiles involves piRNA and mitochondrial small RNAs [0.03%]
品种特异性公猪精子调控谱系的分化涉及piRNA和线粒体小分子RNA
Anna Asratian,Signe Isacson,Unn Kugelberg et al.
Anna Asratian et al.
Small non-coding RNAs (sRNAs) act as post-transcriptional regulators and protectors of genomic integrity. Environmental stress and genomic variation can both alter the sRNA composition in sperm, leading to altered offspring phenotypes. Comm...
Soft fibrin matrix instructs macrophage M2 polarization via FABP4-mediated enhancement of fatty acid β-oxidation to alleviate MASH [0.03%]
软纤维蛋白基质通过介导脂肪酸氧化改善巨噬细胞M2极化来缓解MAS病症
Ranran Zhang,Jialong Liu,Wenqing Shan et al.
Ranran Zhang et al.
Background: Macrophage-driven inflammation is a key pathogenic factor in metabolic dysfunction-associated steatohepatitis (MASH). While fibrin deposition is observed in MASH livers, its role in regulating macrophage polar...
M1 receptor modulator VU0364572 attenuates cortico-thalamo-striatal transmission and facilitates cocaine CPP extinction [0.03%]
M₁受体调节剂VU0364572可减弱皮层-丘脑-纹状体的传递并促进可卡因CPP消退作用
Chao Wu,Cesar R Romero-Leguizamón,Amir Rezagholizadeh et al.
Chao Wu et al.
Cocaine use disorder (CUD), marked by persistent drug-seeking and frequent relapse, remains without an effective pharmacological therapy. Modulation of the M1 muscarinic receptor has emerged as a promising therapeutic strategy. VU0364572, a...
Enhanced fatty acid availability rewires fibroblasts metabolism and decreases collagen deposition in lung fibrosis [0.03%]
脂肪酸可用性增强可重构成纤维细胞代谢并减少肺纤维化中的胶原沉积
Gabriela Wojcik,Anita Sahu-Osen,Pamela Waked et al.
Gabriela Wojcik et al.
Pulmonary fibrosis is characterized by irreversible remodeling of the lung parenchyma, which leads to a progressive deterioration in lung function. Pro-fibrotic fibroblasts contribute to uncontrolled extracellular matrix deposition and prog...
Fusobacterium nucleatum regulates nicotinamide metabolism via the upregulation of NNMT to activate PARP1/MAPK signalling in colitis-associated cancer [0.03%]
福氏耐养奈瑟菌通过上调NNMT激活PARP1 / MAPK信号通路调节烟酰胺代谢在结肠炎相关癌症中的作用
Jing Lei,Peiyu Yang,Feng Xu et al.
Jing Lei et al.
Colitis-associated cancer (CAC) is a serious complication of inflammatory bowel disease (IBD). Recent evidence has indicated that Fusobacterium nucleatum (F. nucleatum) may promote intestinal inflammation and carcinogenesis. However, the ef...
Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila [0.03%]
线粒体DBP缺陷通过干扰果蝇脂质稳态导致雄性不育
Jia Wang,Yanbin Ma,Yunbo Wang et al.
Jia Wang et al.
Peroxisomes are essential organelles in almost all eukaryotic cells with a variety of functions in cellular metabolism, including β-oxidation of very-long-chain fatty acids (VLCFAs). Impairment in peroxisome biogenesis or single enzyme fun...
MYCN and helicases DDX17 and DDX5 have opposite effects on the production of readthrough-associated chimeric transcripts [0.03%]
MYCN和解旋酶DDX17及DDX5对阅读扩展相关融合转录本产生的相反影响
Valentine Clerc,Khouaila Aouadi,Jessica Valat et al.
Valentine Clerc et al.
DEAD box helicases DDX17 and DDX5 control transcription termination and the associated processing of the 3' end of pre-messenger RNAs. Here, we demonstrate that the transcriptional readthrough induced by DDX17 depletion, either alone or in ...
Emma Valima,A B M Kaiser Manjur,Eevi Savinainen et al.
Emma Valima et al.
SUMOylation has emerged as a key regulator of chromatin and transcription, yet its contribution to lineage reprogramming remains unclear. To explore how chromatin SUMOylation influences cellular plasticity, we studied CEBPA-driven lineage r...
cGAMP suppresses FTO expression to promote m6A modification and potentiate antitumor immunity [0.03%]
cGAMP通过抑制FTO表达促进mRNA m6A修饰从而增强抗肿瘤免疫应答
Pan Feng,Xiaolan Chen,Dong Guo et al.
Pan Feng et al.
Cyclic GMP-AMP (cGAMP) serves as a pivotal second messenger in the cGAS‒STING innate immune signaling pathway and plays a critical role in antiviral and antitumor immunity; however, its regulatory mechanisms governing the epitranscriptome ...