The crosstalk between lymphatic endothelial cells and immune cells in Physiological and Pathological conditions [0.03%]
生理和病理条件下的淋巴内皮细胞与免疫细胞的相互作用
Weijie Chen,Yongheng Wang,Da Zhang et al.
Weijie Chen et al.
The lymphatic system serves two primary functions: the absorption of interstitial fluid and the coordination of immune cell interactions and transport. Central to these roles is the dynamic interplay between lymphatic endothelial cells (LEC...
Lena Jentsch,Natascia Ventura
Lena Jentsch
Mitochondrial complex I is the first and largest enzyme of the mitochondrial respiratory chain and thus plays a crucial role in cellular energy metabolism. Defects in the mitochondrial respiratory chain, and in particular CI deficiency, are...
Extracellular vesicle-derived TMEM106A participated in podocyte injury via EGR1 in preeclampsia [0.03%]
子痫前期的外泌体TMEM106A通过EGR1参与足细胞损伤
Dongdong Zhang,Ning Shen,Xia Zhang et al.
Dongdong Zhang et al.
Preeclampsia (PE), a pregnancy-specific hypertensive disorder affecting approximately 5-8% of pregnancies, is a leading cause of maternal and fetal morbidity and mortality. Although renal complications, particularly podocyte injury, are hal...
Depression-induced systemic C16-ceramide deficiency promotes OSCC via attenuation of mitochondrial apoptosis [0.03%]
抑郁症通过抑制线粒体凋亡诱导系统性十六碳酰胺缺乏促进口腔鳞状细胞癌的发展
Yuan Pan,Jingjing Guan,Yueqi Wang et al.
Yuan Pan et al.
Depression is a recognized risk factor for cancer progression, but the underlying metabolic mediators remain unclear. Here, we identify circulating C16-ceramide depletion as a key mechanism linking depression to oral squamous cell carcinoma...
TRIM47 drives metabolic reprogramming and tumor progression in Nasopharyngeal Carcinoma via K48-linked ubiquitination and degradation of SDHB [0.03%]
TRIM47通过K48泛素化和降解SDHB驱动鼻咽癌的代谢重组和肿瘤进展
Jieqing Yu,Le Ding,Yong Yang et al.
Jieqing Yu et al.
Nasopharyngeal carcinoma (NPC) remains a therapeutically challenging malignancy due to its late diagnosis and limited treatment efficacy. Although metabolic reprogramming is a hallmark of cancer, the ubiquitin-mediated mechanisms underlying...
Correction to:Transcriptomic landscape reveals germline potential of porcineskin‑derived multipotent dermal fibroblast progenitors [0.03%]
图修正：转录组景观揭示了猪皮肤衍生的多能真皮纤维芽细胞祖细胞的生殖系潜力
Wen-Xiang Liu,Chun-Xiao Li,Xin-Xiang Xie et al.
Wen-Xiang Liu et al.
Epithelial-mesenchymal transition and immunosuppression: Two sides of the same coin [0.03%]
上皮间质转化和免疫抑制：同一个硬币的两面
Brian Feng,Anushka Dongre
Brian Feng
Epithelial-mesenchymal transition has long been studied as a physiologic process that is critical for embryonic development, wound healing, and cancer progression. Activation of the EMT program confers on cancer cells many cellular traits a...
The significance of the ketolytic gene OXCT1 in metabolism, intracellular signaling and disease development [0.03%]
酮体分解基因OXCT1在代谢、细胞内信号传导及疾病发展中的意义
Karolina Górecka,Kamila Soboska,Marcin Pacholczyk et al.
Karolina Górecka et al.
OXCT1 (3-oxoacid CoA-transferase 1), encoding the mitochondrial enzyme SCOT (succinyl-CoA:3-ketoacid CoA transferase), is a key enzyme in ketone body utilization. It catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate...
ALYREF stabilizes MZF1 via m5C modification to exacerbate cardiac remodeling and atrial fibrillation in heart failure [0.03%]
心力衰竭中通过mRNA的m5C修饰稳定MZF1从而加重心脏重构和房颤的分子机制研究
Siqi Nian,Lulu Zhao,Xiaokang He et al.
Siqi Nian et al.
Background: Patients with heart failure (HF) frequently develop atrial fibrillation, but the precise molecular mechanisms are unclear, leading to limited therapeutic strategies. ...