TRIM32-mediated ABI2 downregulation promotes anoikis resistance and metastasis by regulating EMT in lung adenocarcinoma [0.03%]
TRIM32介导的ABI2下调通过调节EMT促进肺腺癌的悬垂应激抵抗和转移
Yongting Liu,Zhaohui Jiang,Yulong Zhao et al.
Yongting Liu et al.
Metastasis largely drives the high mortality of lung adenocarcinoma (LUAD), with anoikis resistance acting as a critical mediator in this process. This study aims to reveal the role and mechanism of ABI2 in anoikis resistance and LUAD metas...
Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks [0.03%]
不同的分子和电路机制调节视网膜和视交叉上核昼夜钟的光同步化现象
A Jandot,H Calligaro,A Dianak-Shoori et al.
A Jandot et al.
The circadian system aligns behavior and physiology with the 24-hour environmental cycle through a distributed network of clocks including the master pacemaker in the suprachiasmatic nucleus (SCN) and an autonomous retinal clock critical fo...
Trimerization of CD40L-specific affibody molecules using collagen domains enhances target binding and CD40 blockade [0.03%]
利用胶原蛋白结构域三聚化的CD40L特异性Affibody分子增强靶点结合和CD40阻断作用
Cornelia Westerberg,Chiara Sorini,Mariam Al-Haddad et al.
Cornelia Westerberg et al.
Due to its central role in regulating adaptive immune responses through CD40 engagement, the CD40 ligand (CD40L) represents an attractive therapeutic target for inflammatory and autoimmune diseases. Here, CD40L-specific affibody molecules w...
Pannexin 1 attenuates hepatic steatosis and insulin resistance via AMPK-autophagy axis activation [0.03%]
Panx1通过激活AMPK-自噬轴减轻肝脏脂质沉积和胰岛素抵抗作用
Lijing Zhu,Jiaying Yang,Zhijian Zhang et al.
Lijing Zhu et al.
Background: Metabolic dysfunction-associated fatty liver disease ((MASLD) affects over 25% of the global population, yet effective therapies remain limited. While Pannexin 1 (Panx1) has been implicated in metabolic regula...
Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential [0.03%]
物理相互作用促进CXCR4的细胞内定位及致癌潜能 EphrinB1
Alessandro Rabbito,Omolade Otun,Amos Fumagalli et al.
Alessandro Rabbito et al.
Chemokine receptor 4 (CXCR4) is a member of the chemokine receptor family, exclusively activated by the chemokine CXCL12. While CXCR4 regulates numerous physiological processes associated with cell migration and embryogenesis, its overexpre...
Primary and motile cilia in the efferent ductules: a role for IFT88 in maintaining male fertility [0.03%]
附睾管中的原发性和运动性纤毛：IFT88在维持雄性生育力中的作用
Céline Augière,Louis Hermo,Shirley Ferrier-Tarin et al.
Céline Augière et al.
The efferent ductules are male reproductive tubules that support fertility by reabsorbing fluid and transporting sperm from testis to the epididymis. They are lined with multiciliated cells (MCCs) and reabsorptive primary ciliated cells (RP...
Dual-specificity phosphatase 10 alleviates severe acute pancreatitis via the dephosphorylation of TAK1 [0.03%]
双重特异性磷酸酶10通过TAK1去磷酸化缓解重症急性胰腺炎
Chaopeng Mei,Guanghui Li,Meng Wang et al.
Chaopeng Mei et al.
Severe acute pancreatitis (SAP) is a serious condition characterized by an intense systemic inflammatory response that can lead to persistent multiple organ failure and sepsis. Dual-specificity phosphatase 10 (DUSP10), has been implicated i...
The miR-206-3p/Cpeb1 axis delays acetylcholine receptor degradation and preserves neuromuscular junction stability in denervation-induced muscle atrophy [0.03%]
miR-206-3p/Cpeb1轴通过延缓乙酰胆碱受体的降解来维持脱神经肌肉萎缩中的神经肌接头稳定性
Guohua Jiang,Long Li,Yanhua Wang et al.
Guohua Jiang et al.
Peripheral nerve injury leads to progressive neuromuscular junction (NMJ) destabilization and acetylcholine receptor (AChR) degradation, which are critical drivers of denervation-induced muscle atrophy and impaired motor recovery. However, ...
Interaction between CD82 and integrin αVβ3 selectively regulates collective movement of tumor cells via endolysosomal trafficking [0.03%]
CD82通过内溶酶体转运途径与整合素αvβ3相互作用选择性地调节肿瘤细胞的集体运动
Xue Jun Wang,Mekel M Richardson,Yingjun Ding et al.
Xue Jun Wang et al.
Tetraspanin CD82/KAI1 inhibits cell movement and metastasis of malignant tumors, and reduced and lost expressions of CD82 predict worse outcomes of patients with malignant tumors. Here we found that CD82 inhibits both solitary and collectiv...