Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma [0.03%]
通过SLC25A39-NRF2轴抑制铁死亡驱动肺癌腺癌对奥希替尼的耐药性
Kai Fu,Zhilin Zeng,Wenfeng Wang et al.
Kai Fu et al.
Objective: Overcoming resistance to Osimertinib remains a major clinical challenge in lung adenocarcinoma (LUAD). The molecular mechanisms driving this resistance are still not fully understood. ...
PHLDA1 knockdown exacerbates emphysema in COPD by attenuating proliferation of alveolar type II cells via modulating GLI1 nuclear translocation [0.03%]
PHLDA1通过调节GLI1核转位来抑制II型肺泡细胞增殖从而加重COPD中的肺气肿病理表型
Shuang Bai,Shuaifu Wang,Rui Ye et al.
Shuang Bai et al.
The emphysematous phenotype is an important phenotype in chronic obstructive pulmonary disease (COPD), with substantial morbidity and mortality. The mechanisms underpinning the role of alveolar type II (AT2) cells in alveolar repair within ...
Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk [0.03%]
单细胞解析进行性骨化性纤维发育不良 进而识别SPP1为巨噬细胞与成脂/成软骨前体细胞互作的介导因素
Riccardo Gamberale,Mauro Bergamaschi,Anna Sofia Tascini et al.
Riccardo Gamberale et al.
Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder caused by gain-of-function mutations in ACVR1/ALK2, leading to progressive heterotopic ossification (HO) through endochondral bone formation. Inflammatory flare-ups ofte...
Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway [0.03%]
肾脏管状糖异生酶PCK1的消融通过负向调节TGF-β/Smad3信号通路驱动急性肾损伤转为慢性肾病
Jing-Xuan Gan,Meng-Fan Li,Hai-Hua Deng et al.
Jing-Xuan Gan et al.
The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by progressive renal fibrosis, yet the key tubular regulatory factors driving this maladaptive repair remain inadequately defined. In this study,...
LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti [0.03%]
长链非编码RNA通过调节Dpp介导的翅膀发育影响埃及伊蚊飞行能力
Jianping Cao,Lin Ling
Jianping Cao
The flight capability of Aedes aegypti underpins global spread of vector-borne diseases (e.g., dengue, Zika, chikungunya), making it a key control target. Decapentaplegic (Dpp), evolutionarily conserved in insect morphogenesis, has unclear ...
TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis [0.03%]
TROP2通过与纤连蛋白-整合素轴相互作用促进结直肠癌骨转移
Le-Xin Xiao,Yan-Lin Huang,Chun-Hong Liao et al.
Le-Xin Xiao et al.
Background: Colorectal cancer (CRC) is the third most common cancer in the world. Bone metastasis, which occurs in advanced cancer, causes severe damage and accelerates patient death. TROP2, encoded by the TACSTD2 gene, i...
PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice [0.03%]
PRMT5-Cacna1d轴维持钙稳态以调控小鼠产后运动发育
Jianbo Cao,Zixuan He,Weitai Chai et al.
Jianbo Cao et al.
Epigenetic regulation of neuronal calcium signaling during postnatal cortical development is critical for voluntary movement. Protein arginine methyltransferase 5 (PRMT5) acts as an epigenetic regulator that is involved in movement disorder...
Insung Choi,Sueon Kim,Inwha Baek
Insung Choi
Epigenome editing has emerged as a powerful platform to modulate gene expression in a precise and reversible manner. Recent advances have significantly improved the efficiency, specificity, and durability of epigenome editing systems, enabl...
Correction to: SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes [0.03%]
Correction to：SIRT3激活对成人人类心肌细胞奈布生所致线粒体毒性具有保护作用
Yafei Huang,Hong Liu,Chao Tong et al.
Yafei Huang et al.
The histone demethylase KDM5C aggravates titanium particle-induced osteolysis by promoting macrophage inflammation and osteoclastogenesis [0.03%]
组蛋白脱甲基酶KDM5C通过促进巨噬细胞炎症和破骨细胞生成加重钛颗粒诱导的骨溶解
Zeming Lei,Liangzi Yin,Bin Zhang et al.
Zeming Lei et al.
Wear debris-induced periprosthetic osteolysis (PPO) is a major complication following total joint arthroplasty, leading to implant failure. Macrophage inflammatory response and osteoclastogenesis play important roles in bone destruction and...