Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids [0.03%]
单细胞分析揭示了USH1C视网膜类器官中Müller胶质介导的细胞间通讯受损和感光细胞病理变化
Nicole Wenck,Mark Zorin,Qiang Wang et al.
Nicole Wenck et al.
Usher syndrome type 1, caused by pathogenic variants in the USH1C gene, leads to congenital deafness and progressive retinal degeneration resulting in vision loss. While auditory deficits can be compensated by cochlea implants and hearing a...
Mechanisms and strategies of host xenophagy manipulation by intracellular bacteria [0.03%]
胞内细菌操纵宿主异体吞噬的机制与策略
Yinjuan Song,Li Tang,Na Li et al.
Yinjuan Song et al.
Xenophagy, a specialized form of autophagy, serves as a critical cellular defense mechanism, targeting and degrading intracellular bacterial pathogens. This review explores the intricate interplay between bacteria and host xenophagy, focusi...
RBMX promotes colorectal liver metastasis by stabilizing MTHFD2 mRNA to regulate redox homeostasis [0.03%]
RBMX通过稳定MTHFD2 mRNA调节氧化还原平衡促进结直肠癌肝转移
Chengrong Jiang,Guanyi Liao,Qingling Li et al.
Chengrong Jiang et al.
Background: Liver metastasis is the primary cause of mortality in colorectal cancer (CRC), yet the molecular mechanisms driving colorectal liver metastasis (CRLM) remain poorly understood. This study investigates the role...
Retina-specific long non-coding RNAs associated with inherited retinal disease genes [0.03%]
与遗传性视网膜疾病基因相关的特异性视网膜长链非编码RNA
Emma Delanote,Karla Alejandra Ruiz-Ceja,Alfredo Dueñas Rey et al.
Emma Delanote et al.
Long non‑coding RNAs (lncRNAs) are increasingly recognized as important regulatory molecules, yet their roles remain largely unexplored in many tissues. This study aimed to identify and characterize lncRNAs involved in human retinal biolog...
From Thanatos to transcription: the emerging biology of THAP proteins [0.03%]
从塔纳托斯到转录：THAP蛋白生物学的最新研究进展
Bryce Rampal,Alexandre Brisson,Louise Ben Hamou Kuijpers et al.
Bryce Rampal et al.
The Thanatos-associated (THAP) protein family, named after the Greek god of death, comprises zinc-finger proteins characterized by a DNA-binding domain called the THAP domain. Although THAP1 and THAP11 have been extensively studied, the bro...
Elektra-Qki and Alien-Wt1 lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice [0.03%]
Elektra-qki 和外星人-wt1 lncrna-蛋白质相互作用控制小鼠心脏发育过程中心肌离子通道表达和心外膜上皮间质转化
Sheila Caño-Carrillo,Estefanía Lozano-Velasco,Diego Franco
Sheila Caño-Carrillo
Background: The heart is the first organ to develop during embryogenesis and its development relies on coordinated interactions between the myocardium and the embryonic epicardium (EE), the third layer of the heart derive...
SHIP1 is required for T cell surveillance of occult malignancies [0.03%]
SHIP1蛋白对T细胞监测隐匿性恶性肿瘤的免疫监视功能是必不可少的
S Fernandes,N Srivastava,C Pedicone et al.
S Fernandes et al.
SHIP1-deficient mice develop severe, transmural Crohn's-like ileitis and die prematurely. Recent analysis of a human Crohn's disease (CD) cohort revealed a significant subset of patients have severely reduced levels of SHIP1 expression sugg...
Reply to: Commentary on "The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of MAPK signaling pathway" [0.03%]
关于“食品添加剂4-己基雷锁辛通过抑制MAPK信号通路损害肠道干细胞功能并加重果蝇(Drosophila melanogaster)炎症性肠病”的评论的回复
Xinxin Fan,Jinhua Yan,Yu Yuan et al.
Xinxin Fan et al.
The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway [0.03%]
由BmCPV衍生的小分子病毒肽vsp1S4(-)通过ROS-JNK信号通路诱导细胞凋亡抑制病毒复制
Xialing Chen,Xiaoyan Du,Lixuan Li et al.
Xialing Chen et al.
Viral antisense RNAs are generally considered noncoding. Here, we show that segment 4 of Bombyx mori cypovirus (BmCPV) encodes a 78-aa antisense-microprotein, vsp1S4(-), that triggers a host-restrictive reactive oxygen species (ROS)-c-Jun N...
UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation [0.03%]
UBE2L6通过促进STK38 ISG化增强三阴性乳腺癌侵袭和转移
Liang Ji,Kang Li,Jing Feng et al.
Liang Ji et al.
Although aberrant activation of autophagy is well known in triple-negative breast cancer (TNBC), its functional roles and underlying mechanisms remain largely unknown. In the present study, we found that high UBE2L6 expression was strongly ...