LAMP2A-dependent chaperone mediated autophagy regulates Notch signaling and controls neural stem cell differentiation [0.03%]
LAMP2A依赖的分子伴侣介导的自噬调控 notch 信号通路并控制神经干细胞分化
Daphne Antoniou,Maria Xilouri,Dimitrios Gkikas et al.
Daphne Antoniou et al.
Protein degradation systems have profound effects on signaling pathways and molecular networks that regulate organogenesis. Chaperone Mediated Autophagy (CMA) has been linked to neurodegenerative and neurodevelopmental diseases, however, it...
Correction to: Computational analysis of multi-omics data reveals CXCL10+ DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma [0.03%]
多组学数据的计算分析揭示了CXCL10+DC-Treg互作驱动AFP阳性肝细胞癌免疫抑制微环境
Zhi-Hui Luo,Wei-Ming Chen,Xin-Meng Yang et al.
Zhi-Hui Luo et al.
The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos [0.03%]
母体RNA结合蛋白4E-T的降解调节合子基因组激活以保证小鼠胚胎母体向合子转换过程顺利进行
Pinhua Wang,Siqi Wang,Haojie Yin et al.
Pinhua Wang et al.
The maternal-to-zygotic transition (MZT) is essential for early embryonic development, comprising zygotic genome activation (ZGA) as well as the degradation of maternal RNAs and proteins, whereas our understanding of repressors' role in thi...
SnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress [0.03%]
snRNA-seq和全基因组CRISPR筛选定义了足细胞应激的完整转录轨迹和功能驱动因素
Jianbo Qing,Jiaying Hu,Xiao Wang et al.
Jianbo Qing et al.
Podocyte injury is a central driver of proteinuria and progressive kidney dysfunction. Although podocytes are continuously exposed to diverse stressors in both physiological and pathological contexts, the dynamic processes underlying their ...
Cellular senescence and aging: molecular mechanisms and convergent pathways [0.03%]
细胞衰老与机体老化：分子机制及途径汇合点
Francesca Cristiana Piritore,Michele Braggio,Arianna Minoia et al.
Francesca Cristiana Piritore et al.
The frequent conceptual overlap between aging and cellular senescence has generated ambiguities in experimental approaches, biomarker usage, and therapeutic strategy development within aging research. Cellular senescence and aging are biolo...
Matrix stiffness induced CREB3L1 activation contributed to skin fibrosis through calcium influx triggered endoplasmic reticulum stress [0.03%]
基质硬度通过钙离子流入触发内质网压力激活CREB3L1促进皮肤纤维化
Dongsheng Wen,Yeke Yu,Siyi He et al.
Dongsheng Wen et al.
Background: Skin fibrosis substantially contributes to morbidity and mortality. Fibrotic remodeling, characterized by accumulated and stiffened extracellular matrix, persistently exerts mechanical cues and consistently ac...
APOC1⁺IFI30⁺ TAMs orchestrate colorectal cancer liver metastasis by coupling cholesterol biosynthesis with secretion of immunosuppressive factors [0.03%]
APOC1⁺IFI30⁺肿瘤相关巨噬细胞通过将胆固醇生物合成与免疫抑制因子的分泌偶联起来，促进结直肠癌肝转移
Zheyou Cai,Yibing Chen,Lei Cui et al.
Zheyou Cai et al.
Tumor-associated macrophages (TAMs) play a crucial role in colorectal cancer (CRC) metastasis, particularly in the establishment of the liver metastatic niche. TAMs facilitate metastasis by enabling epithelial-mesenchymal transition (EMT) a...
Hepatocyte CD146 and soluble CD146 promote hepatic stellate cell activation via the integrin αvβ1-p38 MAPK signaling axis to drive liver fibrosis [0.03%]
肝细胞CD146和可溶性CD146通过整合素αvβ1-p38MAPK信号轴促进肝星状细胞活化以驱动肝纤维化
Bingqing Yang,Chenxue Hou,Rongcai Ye et al.
Bingqing Yang et al.
During chronic liver injury, hepatocytes promote liver fibrosis by interacting with hepatic stellate cells (HSCs). However, the key intracellular factors that regulate intercellular communication in hepatocytes remain poorly understood. Alt...
The formin Fhod3 is required for sarcomere reassembly after mitosis in postnatal cardiomyocytes [0.03%]
佛林蛋白Fhod3在产后心肌细胞有丝分裂后的横纹肌节重组中是必需的
Shuhei Sakaguchi,Yohko Kage,Eka Adip Pradipta et al.
Shuhei Sakaguchi et al.
Fhod3, a member of the formin family of proteins that regulate actin polymerization, is essential for the organization of cardiac sarcomeres during embryonic cardiogenesis. We previously demonstrated that the perinatal deletion of Fhod3 in ...
Apolipoprotein D acts as a chaperone of Aβ peptide delaying its assembly into amyloid aggregates [0.03%]
载脂蛋白D作为淀粉样前体蛋白的分子伴侣通过延缓其聚集来抑制淀粉样斑块的形成
Jorge Mondejar-Duran,Antonio Díaz-Quintana,Maria D Ganfornina et al.
Jorge Mondejar-Duran et al.
The accumulation of amyloid-β (Aβ) peptides is at the root of Alzheimer's disease (AD), where oligomeric forms of Aβ disrupt brain physiology before any sign of dementia. Intense research has been directed to extrinsic molecules that mod...