SOX10-mediated regulation of the MiR-106a/363 cluster drives RAF inhibitor resistance in BRAF-mutant melanoma [0.03%]
SOX10介导的MiR-106a/363簇调节驱动BRAF突变黑色素瘤中的RAF抑制剂抗性
Ying Li,Yu-le Yong,Zhe Zhi et al.
Ying Li et al.
Adaptive resistance to MAPK inhibitors remains a major clinical obstacle in BRAF-mutant melanoma, driven by reversible transcriptional and epigenetic reprogramming. Previous studies have implicated loss of SRY-box transcription factor 10 (S...
Vestibular hair cell redundancy and the critical requirement of type I cells for balance maintenance [0.03%]
前庭毛细胞的冗余和I型细胞维持平衡的关键要求
Yikang Huang,Wenli Ni,Qin Zhou et al.
Yikang Huang et al.
Vestibular hair cells (HCs) are sensory mechanotransducers essential for balance and spatial orientation, yet the relative contributions of HC number and subtype to vestibular function remain unresolved. Here, we developed a dose-dependent ...
Correction to: Knockdown of Foxg1 in supporting cells increases the trans‑differentiation of supporting cells into hair cells in the neonatal mouse cochlea [0.03%]
题为“耳蜗支撑细胞敲低Foxg1可促进新生小鼠耳蜗支撑细胞向毛细胞转分化”的校正通知
Shasha Zhang,Yuan Zhang,Ying Dong et al.
Shasha Zhang et al.
Upregulation of PTPRO by WT1 alleviates podocyte injury in diabetic nephropathy through inhibiting the c-Abl/p53 pathway [0.03%]
WT1通过抑制c-Abl/p53通路上调PTPRO缓解糖尿病肾病podocytes损伤
Hengjiang Guo,Li Wang,Yiru Tong et al.
Hengjiang Guo et al.
Podocyte injury plays a central role in the pathogenesis of diabetic nephropathy (DN). Protein tyrosine phosphatase receptor type O (PTPRO) has been implicated in glomerular disease, yet its specific role and regulatory mechanism in DN rema...
ENO3-mediated glycolytic reprogramming participates in β-glucan-induced dendritic cells activation and anti-tumor responses [0.03%]
ENO3介导的糖酵解重编程参与β-葡聚糖诱导的树突状细胞活化和抗肿瘤反应中
Jun Ding,Yongzhe Hao,Meng Yuan et al.
Jun Ding et al.
Dendritic cells (DCs) are key initiators of antitumor immunity, yet the metabolic drivers governing their activation remain incompletely defined. Here, we show that the fungal immunomodulator β-glucan induces robust immune-metabolic reprog...
Molecular mechanisms and translational implications in apoptosis, ferroptosis, pyroptosis, and cuproptosis of spermatogonial stem cells [0.03%]
生精干细胞凋亡、铁死亡、炎性坏死及铜依赖性细胞死亡的分子机制及其翻译意义研究进展
Feng Deng,Jianghong Xiang,Zuping He
Feng Deng
Spermatogonial stem cells (SSCs) are essential for male fertility because they form the cellular foundation for normal spermatogenesis. Here we address the regulatory mechanisms governing cell deaths of SSCs, e.g., apoptosis, ferroptosis, p...
FADS1-mediated Efferocytosis in Tumor-Associated Macrophages Shapes an Immunosuppressive Microenvironment in Gastric Cancer [0.03%]
胃癌相关巨噬细胞中FADS1介导的促炎型肿瘤坏死因子信号通路促进效应T细胞凋亡及免疫逃逸
Yingjing Zhang,Rongyuan Wei,Pengfei Su et al.
Yingjing Zhang et al.
Tumor-associated macrophages (TAMs) play a central role in tumor progression and therapeutic resistance. Alterations in unsaturated fatty acids (UFAs) metabolism are known to contribute to the immunosuppressive properties of TAMs. However, ...
Moesin is an ανβ3 integrin-interacting protein that affects endothelial cell activation and angiogenesis through balancing c-Met and VEGFR2 activation [0.03%]
Moesin通过调控c-Met和VEGFR2的活性平衡来影响内皮细胞激活及血管生成且为ανβ3整合素互作蛋白
Michaela-Karina Enake,Wanjing Lai,Sotiria Tsirmoula et al.
Michaela-Karina Enake et al.
Moesin (Msn) is a member of the ERM (Ezrin, Radixin, and Moesin) protein family implicated in cell-cell recognition, cell adhesion, and migration. In this work, we identified Msn as an ανβ3 integrin-interacting molecule in human endothel...
Structural and biochemical characterization of a novel DinG containing an endonuclease domain [0.03%]
一种新型含endonuclease结构域的DinG的结构与生化研究
Shen Li,Tianwen Gao,Wanshan Hao et al.
Shen Li et al.
DinG-like proteins are members of the XPD-family SF2 helicases and are widely distributed in bacteria, yet they exhibit remarkable diversity in domain architecture and biological function. A distinct subgroup of DinG homologs harboring an N...
Mesenchymal stem cell-derived exosomes alleviate post-resuscitation brain injury by inhibiting neuronal ferroptosis partly via the PRMT1/SLC7A11/GPX4 pathway [0.03%]
间充质干细胞衍生的外泌体通过PRMT1/SLC7A11/GPX4通路抑制神经元铁死亡来缓解复苏后脑损伤
Lulu Li,Lan Ying,Lu He et al.
Lulu Li et al.
Background: Post-resuscitation brain injury is the main contributor to the death and disability of cardiac arrest (CA) victims. Neuronal ferroptosis is involved in the pathogenesis of brain injury after resuscitation, whi...