Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation [0.03%]
截短的tau会干扰自噬和内溶酶体途径并导致脂质聚集
Saskia J Pollack,Dina Dakkak,Tong Guo et al.
Saskia J Pollack et al.
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain in tauopathies, and defects in this system are associated with disease pathogenesis. Here, we report that expression ...
DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2 [0.03%]
DAP12与RER1相互作用并在与TREM2组装之前保留在分泌途径中
Yanxia Liu,Sandra Theil,Melanie Ibach et al.
Yanxia Liu et al.
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with several immunoreceptors forming functional complexes that trigger intracellular signaling pathwa...
Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy [0.03%]
维生素C通过使c-Jun氨基末端激酶失活来稳定心脏和神经嵴衍生物表达蛋白1（HAND1）以调节胎盘发育并维持妊娠
Haibin Zhu,Huan Luo,Xiaowei Wu et al.
Haibin Zhu et al.
Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscure. Here, we demonstrated that ...
A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels [0.03%]
无活性KV亚基与KV7钾通道间功能上的交互作用
Vijay Renigunta,Nermina Xhaferri,Imran Gousebasha Shaikh et al.
Vijay Renigunta et al.
Voltage-gated K+ (KV) channels govern K+ ion flux across cell membranes in response to changes in membrane potential. They are formed by the assembly of four subunits, typically from the same family. Electrically silent KV channels (KVS), h...
GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress [0.03%]
GPR116通过抑制内质网应激缓解小鼠的乙酰氨基酚致肝损伤
Qian Xiang,Na Li,Yan Zhang et al.
Qian Xiang et al.
Background: Acetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein-coupled receptor 116 (GPR116) is an important homeostatic maintenance molecule in the body, but litt...
Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis [0.03%]
CXCL9/10在小鼠金黄色葡萄球菌骨髓炎先天免疫反应中的年龄相关失调现象
Yihuang Lin,Mankai Yang,Chubin Cheng et al.
Yihuang Lin et al.
Background: Age-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus aureus (S. aureus) infection in the bone tissue. However, the basis for...
Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation [0.03%]
乳酸通过组蛋白H3K18乳酰化而非H3K27乙酰化调节卵裂球基因组激活
Yanhua Zhao,Meiting Zhang,Xingwei Huang et al.
Yanhua Zhao et al.
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development remains elusive. Previous studies have implicated lactate accumulation in medium affecting histone acetylation. Recent re...
Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord [0.03%]
取自动脉华通胶细胞的类人胚盘状结构具有人类植入后胚胎的特征
Yoshihiro Kushida,Yo Oguma,Kana Abe et al.
Yoshihiro Kushida et al.
Muse cells, identified as cells positive for the pluripotent surface marker SSEA-3, are pluripotent-like endogenous stem cells located in the bone marrow (BM), peripheral blood, and organ connective tissues. The detailed characteristics of ...
Lin Zhang,Iris Woltering,Mathias Holzner et al.
Lin Zhang et al.
Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for macrophage migration inhibitory factor (MIF), a pleiotropic cytokine and major determinant of various acute and chronic ...
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis [0.03%]
BRD4抑制靶向缓解NLRP3炎性体活化和GSDMD介导的肝细胞焦亡导致的肝细胞脂毒性
Fangyuan Chen,Shuyu Li,Min Liu et al.
Fangyuan Chen et al.
Nod-like receptor family pyrin-containing protein 3 (NLRP3) inflammasome plays a pathologic role in metabolic dysfunction-associated steatohepatitis (MASH), but the molecular mechanism regulating the NLRP3 inflammasome activation in hepatoc...