Mitochondrial ribosomal protein MRPL27 supports glioma malignancy through regulation of oxidative phosphorylation [0.03%]
线粒体核糖体蛋白MRPL27通过调节氧化磷酸化促进胶质瘤恶性发展
Jingyao Gu,Boya Zhou,Lin Ji et al.
Jingyao Gu et al.
Glioma is a highly invasive primary brain tumor with a poor prognosis and currently lacks effective treatment methods. Increasing evidence indicates that mitochondrial oxidative phosphorylation (OXPHOS) is crucial for the development of gli...
NR5A2 controls gene expression and chromatin contacts of essential circadian metabolic genes in the liver [0.03%]
NR5A2调控肝脏中重要昼夜节律代谢基因的表达和染色质相互作用
Abraham Román-Figueroa,Juan Carlos Gómora-García,Luis Tenorio-Hernández et al.
Abraham Román-Figueroa et al.
Circadian regulation of gene expression relies on the coordinated action of core clock components, tissue-specific transcription factors, and epigenetic mechanisms, including dynamic enhancer-promoter interactions. Although rhythmic chromat...
Identification of the critical immune-related drivers shared by non-alcoholic fatty liver disease and osteoporosis [0.03%]
识别非酒精性脂肪肝和骨质疏松共有的关键免疫驱动因素
Feifan Chang,Siliang Ge,Mingming Zhang et al.
Feifan Chang et al.
Background: Non-alcoholic fatty liver disease (NAFLD) and osteoporosis (OP) are two closely linked diseases, with immune cell dysregulation as a pivotal shared cause. However, the key drivers behind their pathogenesis rem...
Acute-on-chronic liver failure-associated CD45+ EPCs reduced survival via promoting fatty acid β-oxidation in vascular endothelial cells [0.03%]
急性肝衰竭相关CD45+EPCs通过促进血管内皮细胞脂肪酸β氧化降低患者生存率
Xing Li,Nan Zhang,Xiu-Qing Pang et al.
Xing Li et al.
Acute-on-chronic liver failure (ACLF) is associated with high mortality and multi-organ damage in chronic liver disease. This study investigated the role of CD45+ erythroid progenitor cells (EPCs) in ACLF progression and underlying mechanis...
Molecular mechanisms and therapeutic strategies of glomerular cell senescence in diabetic kidney disease: from heterogeneity to precision intervention [0.03%]
糖尿病肾病中系膜细胞衰老的分子机制和治疗策略：从异质性到精准干预
Zhitao Zeng,Jiazhen Shang,Shouyu Chai et al.
Zhitao Zeng et al.
Diabetic kidney disease (DKD) has emerged as a major cause of end-stage renal disease (ESRD) worldwide, with approximately 30%-40% of diabetic patients progressing to DKD and 25% eventually requiring renal replacement therapy. Glomerular ce...
mTORC1-signaling switches megalin function from endocytosis to cell cycle progression [0.03%]
mTORC1信号转导通路通过切换蛋氨酸分泌可调控巨胞饮功能由内吞向细胞周期进程中的作用
Eileen Dahlke,Madlen Kunke,Hannah Knöfler et al.
Eileen Dahlke et al.
Mechanistic target of rapamycin (mTOR) signaling pathway controls eukaryotic growth by regulating metabolism, translation, autophagy and cell cycle. Genetic deletion of renal mTORC1 led to a Fanconi-like syndrome with reduction of the renal...
Obesity-induced oleic acid metabolic dysregulation may exacerbate osteoarthritis through the degradation of SOX9 [0.03%]
肥胖引起的油酸代谢紊乱可能通过SOX9的降解加剧骨关节炎
Haoke Li,Jiawei Fu,Juan Liu et al.
Haoke Li et al.
Obesity-related osteoarthritis (OA) is a degenerative joint disease accompanied by metabolic disorders. However, the specific metabolites and their molecular mechanisms remain unclear. Here, we establish a mouse model of obesity by feeding ...
Marina Barba-Aliaga,Lianqi Chi,Samoa Prieto-Díez et al.
Marina Barba-Aliaga et al.
Maintaining balanced cellular protein levels requires precise control of gene expression and effective coordination between the various stages of the process, from transcription to translation. In recent years, several components of the tra...
MSL2 disruption leads to autism-like behaviors, impairs neurogenesis, and alters histone H4K16 acetylation [0.03%]
MSL2缺失会导致自闭症样行为，并影响神经发生和组蛋白H4K16乙酰化
Shengjie Luo,Shiyi Qu,Senwei Tan et al.
Shengjie Luo et al.
Neurodevelopmental disorders (NDDs) are frequently associated with dysregulation of epigenetic mechanisms. Recent studies have implicated variants in components of the Male-Specific Lethal (MSL) complex, including MSL2, in NDD pathogenesis....
CerS6 orchestrates mitochondrial-immune crosstalk via BNIP3-dependent mitophagy suppression and mtDNA-STING/NLRP3 activation in acute lung injury [0.03%]
CerS6通过BNIP3依赖的线粒体自噬抑制和mtDNA-STING / NLRP3活化在急性肺损伤中调节线粒体-免疫相互作用
Guoqing Luo,Dinghui Li,Zhiwei Wang et al.
Guoqing Luo et al.
Acute lung injury (ALI) is characterized by impaired alveolar epithelial barrier function and mitochondrial dysfunction in type II alveolar epithelial cells (AT2 cells). Ceramide synthase 6 (CerS6), a key enzyme in sphingolipid metabolism r...