Correction: Trimerization of CD40L-specific affibody molecules using collagen domains enhances target binding and CD40 blockade [0.03%]
题图说明:使用胶原蛋白结构域使CD40L特异性Affibody分子三聚化可增强靶点结合和阻断CD40活性
Cornelia Westerberg,Chiara Sorini,Mariam Al-Haddad et al.
Cornelia Westerberg et al.
Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site [0.03%]
Munc18不同异构体的功能差异反映了它们与胞吐位点的亲和力的不同
Liangwen Liu,Santiago Echeverry,Muhmmad Omar-Hmeadi et al.
Liangwen Liu et al.
The SM-protein Munc18 and its binding partner syntaxin are crucial for two distinct steps of regulated exocytosis, docking of secretory granules at the release site, and priming reactions that prepare docked granules for Ca2+ dependent fusi...
Helicobacter pylori and Porphyromonas gingivalis infections as emerging biomarkers associated with Correa's cascade [0.03%]
幽门螺旋杆菌和齿龈卟啉单胞菌感染与Correa进展序列相关的新兴生物标志物
Jannis Kountouras,Evangelos Kazakos,Vardaka Elisabeth et al.
Jannis Kountouras et al.
Metabolic fatty acid substrates enhance the structural and mechanical performance of human-induced pluripotent stem cell-derived cardiomyocytes [0.03%]
代谢脂肪酸底物可增强人诱导多能干细胞源性心肌细胞的结构和力学性能
Mahmoud Gaballah,Kirsi Penttinen,Chandra Prajapati et al.
Mahmoud Gaballah et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a powerful platform for disease modeling, drug discovery, and regenerative therapies. However, their clinical and research utility remains limited by their immatur...
Correction to: Primary cilia gene defects in BMSCs induce idiopathic scoliosis [0.03%]
Correction to: 干细胞中主纤毛基因缺陷可致特发性脊柱侧弯
Li Zhang,Wenhui Yang,Zhi Zhao et al.
Li Zhang et al.
Correction: GAS5 mediates notch signaling to exacerbate calcium oxalate-induced renal injury through the NF-κB/NLRP3 axis by promoting macrophage polarization [0.03%]
纠正:GAS5通过促进巨噬细胞极化来介导诺特定理信号,从而通过NF-κB/NLRP3轴加重草酸钙引起的肾损伤
Longchao Zhang,Shushuai Yang,Yuanjiong Qi et al.
Longchao Zhang et al.
Jiro Ogura,Junichi Fujii,Hiroaki Yamaguchi
Jiro Ogura
Secretory and membrane proteins undergo oxidative folding, the process of forming disulfide bonds between cysteine side chains to construct a stable higher-order structure, primarily in the endoplasmic reticulum (ER) followed by further pos...
Transcription factors as essential regulators of myometrial smooth muscle cell function during pregnancy and labor [0.03%]
transcription factors在妊娠和分娩期间作为调节子宫平滑肌细胞功能的必要因子
Sabrina Martini,Palak Gujral,Eduardo Orozco-Alonso et al.
Sabrina Martini et al.
Parturition is a tightly regulated process coordinated by myometrial smooth muscle cells, which generate the uterine contraction required for birth. Preterm labor, defined as labor occurring before 37 weeks of gestation, remains a significa...
Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia [0.03%]
KLF4在内皮细胞中的表达降低触发了与实验性先天性膈疝相关的肺血管异常
Heleen M Kool,Petra E Bürgisser,Gabriela G Edel et al.
Heleen M Kool et al.
Congenital diaphragmatic hernia (CDH) is a rare anomaly with an incidence of 1 in 3000 live births and characterized by defective closure of the diaphragm, lung hypoplasia, and pulmonary vascular remodeling. Although several genes associate...
The expanding landscape of Deltex: signaling crosstalk and clinical implications [0.03%]
德尔特克斯信号网络的扩展景观:信号串扰和临床意义
Vartika Sharma,Pratikshya Sahoo,Mousumi Mutsuddi et al.
Vartika Sharma et al.
The deltex (DTX) gene family encodes RING-type E3 ubiquitin ligases that are central to the regulation of the Notch signaling pathway, a mechanism governing cell fate, differentiation, proliferation, and apoptosis during development and adu...