Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold [0.03%]
新型氨基衍生物的合成、稳定性及生物学评价（含氮吖啶骨架）
Maria Karelou,Anthi Panara,Eleftheria Chatziorfanou et al.
Maria Karelou et al.
Several new amino-substituted aza-acridine derivatives bearing one or two basic side chains have been designed and synthesized. Their anticancer activities were evaluated in vitro against two human cancer cell lines: T24 (urothelial bladder...
Zeolitic-Imidazole Framework (ZIF)-Derived ZnO Doped with Ag for Improved Ethanol Sensing Applications [0.03%]
掺银的ZIF衍生ZnO用于改善乙醇传感性能
Claudio Clemente,Valentina Gargiulo,Luciana Cimino et al.
Claudio Clemente et al.
Materials derived from metal-organic frameworks (MOFs) as MOF-derived oxides retain a highly porous and active structure from the MOF precursor, exhibiting excellent sensing properties. In addition, the tunable nature of MOFs allows the str...
Discovery of Novel Inhibitors of Aspergillus fumigatus DHODH via Virtual Screening, MD Simulation, and In Vitro Activity Assay [0.03%]
基于虚拟筛选、分子动力学模拟及体外活性评价的烟曲霉DHODH抑制剂发现
Kaige Li,Wei Xia,John Z H Zhang
Kaige Li
To address the surge in Aspergillus fumigatus infections among immunosuppressed patients and azole resistance, this study focused on developing novel inhibitors targeting dihydroorotate dehydrogenase (AfDHODH), a key enzyme in fungal pyrimi...
A Case of Competitive Aromatization vs. Sigmatropic [1,5]-Hydrogen Atom Migration in a 1,2,4-Cyclohexatriene Intermediate Derived from a Bis-Enyne Cyclization [0.03%]
由双烯炔环化衍生的1,2,4-环己三烯中间体的竞争性 aromatization与[1,5]氢原子迁移的一个案例
Rong Tang,Qian Xu,Thomas R Hoye
Rong Tang
1,2,4-Cyclohexatrienes are strained, reactive intermediates often formed by the tetradehydro-Diels-Alder (TDDA) reaction of a conjugated enyne bearing a tethered alkyne as the enynophile. The ene component is commonly the π-bond of an arom...
Dynamic Study on Synergy Mechanism and Characteristics of Particle Removal in Electrostatic Atomization [0.03%]
静电雾化颗粒捕集协同机制与特性的动态研究
Chenzi Teng,Yun Zhang,Sida Ren et al.
Chenzi Teng et al.
A laboratory-scale wire plate wet electrostatic precipitator was designed and constructed to investigate the particle enhancement and capture characteristics of electrostatically charged droplets in continuous atomization mode. A comparison...
pH-Sensitive Multiliposomal Containers for Encapsulation and Rapid Release of Bioactive Substances [0.03%]
一种用于生物活性物质包封和快速释放的pH响应型多囊泡递送体系
Anna A Efimova,Tatyana A Abramova,Igor V Yatsenko et al.
Anna A Efimova et al.
A new method of the design of stimuli-sensitive multiliposomal containers for encapsulation and controlled drug release is described. Despite quite a wide choice of pH-sensitive containers, there is still a considerable challenge to synthes...
Synthesis Amphiphilic One-Handed Helical Ladder Polymers with Circularly Polarized Luminescence [0.03%]
具有圆偏振发光的手性单一臂螺旋梯度聚合物的合成
Ziheng Pan,Wei Zheng
Ziheng Pan
Helical ladder polymers attract attention because of their well-defined, one-handed helical ladder structures and unique properties, which differ from precursor polymers that have random-coil conformations. However, the synthesis of helical...
Functionalisation of Lignin-Derived Diols for the Synthesis of Thermoplastic Polyurethanes and Polyester Resins [0.03%]
基于木质素的二醇功能化产物及其在合成热塑性聚氨酯和聚酯树脂中的应用研究
Rachele N Carafa,Justin J S Kosalka,Brigida V Fernandes et al.
Rachele N Carafa et al.
The functionalisation of lignin-derived phenolics (guaiacol, 4-propylguaiacol, eugenol, isoeugenol, phenol, m-cresol, catechol, syringol, syringaldehyde, and vanillin) for the synthesis of thermoplastic polyurethanes (PUs) and polyester (PE...
On the Stability of Steroids upon Gamma and E-Beam Irradiation and the Protective Effect of Inert Conditions [0.03%]
惰性条件下γ射线及电子束辐照甾体化合物的稳定性研究
Quinten Speleers,Anke Meyers,Homaira Rashid et al.
Quinten Speleers et al.
The sterility of ophthalmic drugs is a fundamental requirement for ensuring patient safety, and as such, it is subject to stringent regulatory standards. However, significant gaps remain regarding the effect of sterilization techniques on t...
Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor [0.03%]
基于NiCoP/PVP/PAN/CNFs电化学发光传感器快速检测人血和尿液中的马来酸氯苯那敏
Yi Zhang,Jiayu Zhao,Jiaxing Chen et al.
Yi Zhang et al.
Chlorpheniramine maleate (CPM) is a first-generation antihistamine that is frequently used to treat allergic reactions. However, excessive consumption presents potential health risks. Therefore, it is crucial to develop a quick and precise ...