Engineering a Radiohybrid PSMA Ligand with an Albumin-Binding Moiety and Pharmacokinetic Modulation via an Albumin-Binding Competitor for Radiotheranostics [0.03%]
一种工程放射杂交PSMA配体与白蛋白结合部位和通过白蛋白结合竞争者进行药代动力学调节的放射治疗诊断方法
Saki Hirata,Hiroaki Echigo,Masayuki Munekane et al.
Saki Hirata et al.
The prostate-specific membrane antigen (PSMA) is a well-established target for radiotheranostics in prostate cancer. We previously demonstrated that 4-(p-astatophenyl)butyric acid (APBA), an albumin-binding moiety (ABM) labeled with astatin...
Synthesis, Characterization, and Properties of Novel Coplanar Bicyclic Compounds Based on Triazolofurazane Compounds [0.03%]
基于三唑 furyl azine化合物的新型共面 bicyclic化合物的设计合成与性能研究
Mei-Qi Xu,Wen-Shuai Dong,Qamar-Un-Nisa Tariq et al.
Mei-Qi Xu et al.
In this study, a C-C bond-linked triazole-fused oxadiazole energetic compound, 4-amino-5-(4-amino-1,2,5-oxadiazol-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one (1), was successfully designed and efficiently synthesized. Following nitration, a fu...
Angelika Myśliwiec,Dorota Bartusik-Aebisher,David Aebisher
Angelika Myśliwiec
Nitric oxide (NO), the first gaseous molecule identified as a signaling mediator, plays a pivotal role in numerous physiological processes including cardiovascular regulation, immune response, and neurotransmission. Synthesized from L-argin...
Inversion Motion of Xanthene and Detection of Its Oxidation Product Xanthone from Gas-Phase Rotational Spectroscopy [0.03%]
基于气相旋转光谱的烷稀内翻转运动及氧化产物烷酮的探测研究
Celina Bermúdez,Manuel Goubet,Elias M Neeman
Celina Bermúdez
The rotational spectra of xanthene and its oxidation product xanthone were investigated by combining quantum chemical calculations with Fourier transform microwave spectroscopy in a jet-cooled environment. Xanthone was unexpectedly generate...
Comparison of Polyphenolic Content and Bioactivities Between Extracts from the Living Plants and Beach Deposits of the Submerged Brackish Water Angiosperm Ruppia maritima [0.03%]
来自略带咸味的沉水被子植物海洋罗皮亚的活体植物和海滩沉积物提取物的多酚类含量及生物活性比较
Alkistis Kevrekidou,Nikolaos Goutzourelas,Stavroula Savvidi et al.
Alkistis Kevrekidou et al.
Bioactive extracts from living plants (LR) and beach deposits (NR) of the submerged brackish water angiosperm Ruppia maritima were examined for their antioxidant activity and anticancer potential. LR extract scavenged effectively free radic...
Comparative Study
Molecules (Basel, Switzerland). 2025 Jun 29;30(13):2800. DOI:10.3390/molecules30132800 2025
Antimicrobial Activity of Cinnamon, Tea Tree, and Thyme Essential Oils Against Pathogenic Bacteria Isolated from Tilapia (Oreochromis spp.) in Aquaculture Farms [0.03%]
肉桂、茶树和百里香精油对抗水产养殖鱼场采集的尼罗罗非鱼病原菌的抗菌活性研究
Karen A Terrazas-Pineda,Liliana Alamilla-Beltrán,Claudia Ariadna Acero-Ortega et al.
Karen A Terrazas-Pineda et al.
Overexploitation has led to a rise in pathogenic bacteria within aquaculture, increasing reliance on antibiotics, and developing microorganism resistance. This situation underscores the need to explore alternatives with a reduced ecological...
Development of Melt-Castable Explosive: Targeted Synthesis of 3,5-Dinitro-4-Methylnitramino-1-Methylpyrazole and Functional Derivatization of Key Intermediates [0.03%]
可熔铸猛炸药的研制：3,5-二硝基-4-甲基硝氨基-1-甲基吡唑及关键中间体功能衍生化研究
Elena Reinhardt,Lukas Bauer,Antonia H Stadler et al.
Elena Reinhardt et al.
The problems associated with TNT necessitate the development of novel melt-castable compounds with melting points between 70 and 120 °C, a crucial endeavor in the field of energetic materials. This study introduces a promising melt-castabl...
Portable and Rapid Smartphone-Based Colorimetric Assay of Peracetic Acid for Point-of-Use Medical/Pharmaceutical Disinfectant Preparation [0.03%]
一种基于智能手机的便携式过醋酸现场配制医用/药用消毒剂的比色测定法
Suphakorn Katib,Sutasinee Apichai,Jutamas Jiaranaikulwanitch et al.
Suphakorn Katib et al.
A simple and rapid smartphone-based colorimetric assay for peracetic acid concentration was developed to facilitate point-of-use disinfectant preparations for infection prevention and control. The colorimetric detection was based on the oxi...
Synthesis of Conjugated Tris- and Tetrakis (Carbazolyl) Azulenes with Intense Emission in the Visible Range [0.03%]
具有可见光发射的三并和四并（咔唑基）偶氮烯的合成
Amantay Iskanderov,Nurlan Merkhatuly,Ablaykhan Iskanderov et al.
Amantay Iskanderov et al.
New conjugated carbazolyl-substituted azulenes, such as 1,2,3-tris(carbazolyl)azulene and 1,2,3,6-tetrakis(carbazolyl)azulene, were synthesized via cross-coupling reactions in high yields. The resulting compounds exhibit a significant abili...
Mechanisms of Action of Propofol in Modulating Microglial Activation in Ischemic Stroke [0.03%]
丙泊酚调节缺血性脑卒中微胶质活化的机制研究
Pouria Abdolmohammadi,Bashir Bietar,Juan Zhou et al.
Pouria Abdolmohammadi et al.
Ischemic stroke, responsible for the majority of stroke cases worldwide, triggers profound neuroinflammatory responses largely mediated by microglia. Excessive activation of pro-inflammatory microglia exacerbates neuronal injury, highlighti...