Integration Viewpoint Using UHPLC-MS/MS, In Silico Analysis, Network Pharmacology, and In Vitro Analysis to Evaluate the Bio-Potential of Muscari armeniacum Extracts [0.03%]
基于UHPLC-MS/MS、网络药理学和体外分析等多维度评价番红花提取物生物活性的整合研究观点
Nilofar Nilofar,Gokhan Zengin,Mehmet Veysi Cetiz et al.
Nilofar Nilofar et al.
The current study investigates the chemical profiling, antioxidant activities, and enzyme inhibitory and cytotoxic potential of the water and methanolic extracts of different parts (flower, leaf, and bulb) of Muscari armeniacum. Chemical pr...
Unveiling Vibrational Couplings in Model Peptides in Solution by a Theoretical Approach [0.03%]
基于理论方法揭示溶液中模型肽的振动耦合
Federico Coppola,Fulvio Perrella,Alessio Petrone et al.
Federico Coppola et al.
Vibrational analysis of peptides in solution and the theoretical determination of the effects of the microenvironment on infrared and Raman spectra are of key importance in many fields of chemical interest. In this work, we present a comput...
Dual Signal Enhancement by Magnetic Separation and Split Aptamer for Ultrasensitive T-2 Toxin Detection [0.03%]
基于磁性分离和拆分型适配体的双信号增强检测技术实现DON超灵敏定量检测
Ziyi Yan,Ping Zhu,Chaoyi Zhou et al.
Ziyi Yan et al.
T-2 toxin, a type A trichothecene mycotoxin produced by Fusarium species, is widely present in cereals and their processed products, posing a significant contaminant in food safety. To address the food safety challenges caused by this toxin...
Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications [0.03%]
医药化学中肼基化合物的强大工具：合成、反应性和生物应用
Sofia Teixeira,Elisabete M S Castanheira,M Alice Carvalho
Sofia Teixeira
The increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of no...
Dual Opioid-Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities [0.03%]
具有减少耐受性风险的双重阿片肽类小分子配体表现出镇痛作用
Marco Mottinelli,V Blair Journigan,Samuel Obeng et al.
Marco Mottinelli et al.
Neuropeptide FF (NPFF) receptor antagonists prevent morphine-mediated antinociceptive tolerance, and compounds with dual mu opioid receptor (MOR) agonist and NPFF antagonist activity produce antinociception without tolerance. Compounds synt...
Floridoside Phosphotriester Derivatives: Synthesis and Inhibition of Human Neutrophils' Oxidative Burst [0.03%]
氟稻side磷三酯衍生物的合成及其对人类多形核白细胞呼吸爆发的抑制作用
Luís Pinheiro,Catarina Cipriano,Filipe Santos et al.
Luís Pinheiro et al.
Floridoside (2-O-D-glycerol-α-D-galactopyranoside) is a natural product typically found in red algae. It serves as the algae's carbon reserve and is produced as a protective response against osmotic and heat stress. Both floridoside and it...
Unveiling the Chemical Composition, Enantiomeric Profile, Antibacterial, Anticholinesterase and Antioxidant Activity of the Essential Oil of Aloysia triphylla Royle [0.03%]
Aloysia triphyllaRoyle精油的化学成分、对映体组成及其抗菌、抗胆碱酯酶和抗氧化活性研究
Cinthia Mejia-Ramos,Julio Reynaldo Ruiz-Quiroz,Maria Elena Salazar-Salvatierra et al.
Cinthia Mejia-Ramos et al.
Aloysia triphylla is widely used in traditional medicine from Peru for its sedative, digestive and anti-inflammatory properties. However, comprehensive studies on the biological activities of its essential oil (EO), particularly from Peruvi...
Nanoporous Carbons from Hydrothermally Treated Alga: Role in Batch and Continuous Capacitive Deionization (CDI) [0.03%]
水热法藻基纳米多孔碳的制备及其在批处理和连续电容去离子中的作用研究
Dipendu Saha,Ryan Schlosser,Lindsay Lapointe et al.
Dipendu Saha et al.
This study presents a sustainable approach for synthesizing high-performance activated carbon from Spirulina Alga through hydrothermal carbonization followed by chemical activation using potassium hydroxide. The resulting activated carbon e...
An Organic Solvent-Tolerant α-L-Rhamnosidase from Dictyoglomus thermophilum and Its Application in Production of Icariside I from Icariin [0.03%]
一株高温菌Dictyoglomus thermophilum的有机溶剂耐受型α-L-鼠李糖苷酶及其在淫羊藿苷I生产中的应用
Jinyue Hu,Lingling Song,Le Zhao et al.
Jinyue Hu et al.
Icariside I, a bioactive flavonoid derivative derived from Herba epimedii, demonstrates better pharmacological properties compared to its precursor icariin. Enzymatic conversion of icariin to icariside I using α-L-rhamnosidase represents a...
Modulation of Human Colon Cell Activity by Synthetic Coumarin Derivatives Bearing a Phosphonate Group [0.03%]
磷ONO酸衍生物调节人类结肠细胞的活性
Katarzyna Szwaczko,Roman Paduch,Kamil Dziuba et al.
Katarzyna Szwaczko et al.
In this paper, we will present the synthesis of coumarins bearing a phosphonate group in the C-3 position of the coumarin skeleton and phosphacoumarin derivatives. The compounds were synthesized by Knoevenagel condensation. Notably, the syn...