The Role of Adenosine A1 and A2a Receptors in Cerebral Blood Vessel Reactivity of Sprague Dawley Rats Exposed to Hyperbaric Oxygenation [0.03%]
高压氧暴露大鼠脑血管反应性中腺苷A1和A2a受体的作用机制研究
Vedran Đambić,Zrinka Mihaljević,Ines Drenjančević et al.
Vedran Đambić et al.
Hyperbaric oxygenation (HBO2) can modify gene and protein expression, signaling pathways, and vascular function, leading to altered vasomotor responses. Adenosine receptors (ARs) may mediate these effects by modulating vasoactivity. This st...
In Search of New Drugs: Elucidating the Activity of Structurally Similar Potential Antibiotics Using Molecular Modelling [0.03%]
寻找新药：利用分子建模研究结构类似潜在抗生素的活性
Natalina Makieieva,Teobald Kupka,Piotr Lodowski et al.
Natalina Makieieva et al.
The global problem of antibiotic resistance leads to the necessity for drug improvement and discovery. Natural and synthetic sulfur-containing compounds have been known as antibiotics for many years. In the current study, we demonstrated an...
Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6 [0.03%]
基于结构的人类白介素-6的小分子抑制剂的设计
Ankit Joshi,Zhousheng Xiao,Shreya Suman et al.
Ankit Joshi et al.
Human Interleukin-6 (hIL-6) is a pro inflammatory cytokine that binds to its receptor, IL-6Rα followed by binding to gp130 and subsequent dimerization to form a hexamer signaling complex. As a critical inflammation mediator, hIL-6 is assoc...
Chirality Transfer and Oxazolidine Formation in Reaction of L and D Enantiomers of β-Hydroxy Amino Acids with Nitrogenous Carboxaldehydes and Nickel(II) [0.03%]
β-羟基氨基酸与含氮甲醛及镍(II)反应中的手性转移和噁唑烷形成研究
Cynthia T Brewer,Greg Brewer,Raymond J Butcher
Cynthia T Brewer
The reaction of either the L (2S3R) or D (2R3S) enantiomers of H2N-C*H(R)CO2- (R = -C*H(OH)CH3 or -C*H(OH)CH(CH3)2) and the L (2S) or D (2R) enantiomers of H2N-C*H(C(CH3)2OH)CO2- with imidazole-4-carboxaldehyde and nickel(II) acetate in met...
Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3- d]pyrimidine Derivatives [0.03%]
新型三环并[2,3-d]嘧啶衍生物的设计、合成及抗肿瘤活性研究
Buer Song,Zarifa Murtazaeva,Lifei Nie et al.
Buer Song et al.
The pyrrolo[2,3-d]pyrimidine (7-deazapurine) scaffold is a unique heterocyclic system included in the composition of most nucleotides. In this study, series of the pyrrolo[2,3-d]pyrimidine-imines and 3-halo-substituted pyrrolo[2,3-d]pyrimid...
Storage and Ripening Monitoring of Pecorino Cheese Through 2D 1H-NMR Relaxation and ANOVA Simultaneous Component Analysis (ASCA): A Comparison with DSC and ATR-FTIR Characterization [0.03%]
基于二维核磁共振和ASCA分析的 pecorino干酪储存及成熟特性监测与DSC和ATR-FTIR表征对比研究
Francesca Di Donato,Francesco Gabriele,Alessandra Biancolillo et al.
Francesca Di Donato et al.
In food processing, non-destructive and non-invasive characterization is a powerful tool for monitoring processes and controlling quality. Cheeses consist of a large variety of products whose nutritional and sensory properties depend on the...
Comparative Study
Molecules (Basel, Switzerland). 2025 Jul 10;30(14):2916. DOI:10.3390/molecules30142916 2025
Intraspecific Variability of Wormwood (Artemisia absinthium L.) Occurring in Poland in Respect of Developmental and Chemical Traits [0.03%]
药用植物虫菊（Artemisia absinthium L.）的种内变异研究——开发和化学特性方面
Olga Kosakowska,Zenon Węglarz,Agnieszka Żuchowska et al.
Olga Kosakowska et al.
The aim of this study was to determine the intraspecific variability among 11 wild-growing populations of wormwood (Artemisia absinthium L.) originating from Central Europe and preserved in the Polish Genebank Collection. The populations we...
Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity [0.03%]
具有高激酶结合亲和力的抗炎三环吲哚酸衍生物
Alexander V Uvarov,Igor A Schepetkin,Mark T Quinn et al.
Alexander V Uvarov et al.
Oximes have been reported to exhibit useful pharmaceutical properties, including compounds with anticancer, anti-arthritis, antibacterial, and neuroprotective activities. Many oximes are kinase inhibitors and have been shown to inhibit vari...
Structurally Ordered NIPUs via Catalyst-Free Synthesis with Hard Segments Based on Erythritol and a Long-Chain Diamine [0.03%]
以 erythritol 和长链二胺为基础的非离子型嵌段聚脲的无催化剂合成及有序结构
Edyta Hebda,Karolina Wróbel,Aleksandra Cieślik et al.
Edyta Hebda et al.
A series of linear isocyanate-free polyurethanes (NIPUs) were obtained via the aminolysis of erythritol dicarbonate (EDC) with polyethers (diamino-PEG, diamino-PPO, and diamino-PEG/PPO) and 1,12-diaminododecane (DADD), which acts as a chain...
Reinforcing Urea-Formaldehyde Resins with Low-Cost, Mechanically Derived Nanocellulose: A Sustainable Approach [0.03%]
用低成本机械法制备的纳米纤维素增强尿素甲醛树脂：一种可持续的方法
Eleni A Psochia,Emmanouil Karagiannidis,Eleftheria Athanasiadou et al.
Eleni A Psochia et al.
In this work, we present the fabrication of low-cost, stable nanocellulose colloidal suspensions with an average particle size of approximately 160 nm, produced via a straightforward, solvent-free ultrasonication process that eliminates the...