A Brand-New Metal Complex Catalyst-Free Approach to the Synthesis of 2,8-Dimethylimidazo[1,2- b]pyridazine-6-Carboxylic Acid-A Key Intermediate in Risdiplam Manufacturing Process [0.03%]
一种全新的金属配合物催化剂自由合成2,8-二甲基咪唑并[1,2-b]吡啶并嗪-6-羧酸的方法-利司磷胺生产工艺中的关键中间体
Georgiy Korenev,Alexey A Gutenev,Fyodor V Antipin et al.
Georgiy Korenev et al.
In this study, we report for the first time a brand-new protocol for the multigram-scale synthesis of 5-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic and 2,8-dimethylimidazo[1,2-b]pyridazine-6-carboxylic acids, without the utilization of ...
Bridging Between Japan-Originated Inorganic Chemistry Theories and the Latest DFT Calculations [0.03%]
连接日本无机化学理论和最新的DFT计算
Takashiro Akitsu
Takashiro Akitsu
There are two concepts that were discovered by Japanese researchers that appear in most inorganic chemistry textbooks: the spectrochemical series [...].
The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design [0.03%]
三氟甲基和三氟甲氧基在药物设计中的作用及意义
Manuel Novás,Maria J Matos
Manuel Novás
One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties. These modifications can strengthen interactions with biolog...
The Potential Anti-Cancer Effects of Polish Ethanolic Extract of Propolis and Quercetin on Glioma Cells Under Hypoxic Conditions [0.03%]
波兰蜂胶乙醇提取物和芸香素在低氧条件下对glioma细胞的潜在抗癌作用
Małgorzata Kłósek,Anna Kurek-Górecka,Radosław Balwierz et al.
Małgorzata Kłósek et al.
Tissue hypoxia is commonly observed in head cancers and contributes to both molecular and functional changes in tumour cells. It is known to stimulate erythropoiesis, angiogenesis, and metabolic alterations within tumour cells. Glioblastoma...
Reversible Binding of Nitric Oxide in a Cu(II)-Containing Microporous Metal-Organic Framework [0.03%]
含铜(II)微孔金属有机骨架中一氧化氮的可逆结合
Konstantin A Bikov,Götz Schuck,Peter A Georgiev
Konstantin A Bikov
We studied the adsorption thermodynamics and mechanism behind the binding of nitric oxide (NO) in the interior surfaces and structural fragments of the high metal center density microporous Metal-Organic Framework (MOF) CPO-27-Cu, by gas so...
NaDES-Based Extracts by Microwave Activation from Laurus nobilis L. Leaves: Sustainable Multifunctional Ingredients for Potential Cosmetic and Pharmaceutical Applications [0.03%]
一种可持续多功能的 laurel 叶子提取物用于潜在的化妆品和医药应用
Debora Caviglia,Eleonora Russo,Anna Maria Schito et al.
Debora Caviglia et al.
Laurus nobilis L. is a widely cultivated plant, used for ornamental purposes, as a high-value spice crop, and in the flavor and fragrance industry. In natural medicine, it is well-known for its many beneficial properties (due to a broad spe...
Sławomir Rubinsztajn,Marek Cypryk,Jan Kurjata et al.
Sławomir Rubinsztajn et al.
Siloxane bond formation represents a fundamental reaction central to both silicone chemistry and its technological applications. This paper presents a novel ketone-assisted process for the condensation of alkoxy-functional silanes catalyzed...
Synthesis of Substituted 1,4-Benzodiazepines by Palladium-Catalyzed Cyclization of N-Tosyl-Disubstituted 2-Aminobenzylamines with Propargylic Carbonates [0.03%]
钯催化N-tosyl-二取代2-氨基苄胺与丙炔酸酯的环化反应合成取代的1,4-苯并二氮杂卓化合物
Masahiro Yoshida,Saya Okubo,Akira Kurosaka et al.
Masahiro Yoshida et al.
A synthesis of substituted 1,4-benzodiazepines has been developed via palladium-catalyzed cyclization of N-tosyl-disubstituted 2-aminobenzylamines with propargylic carbonates. The reaction proceeds through the formation of π-allylpalladium...
Noncovalently Immobilized Glucose Oxidase/Horseradish Peroxidase Cascade on Polyamide Supports for Eco-Friendly Polyaniline Synthesis [0.03%]
基于聚酰胺载体的葡萄糖氧化酶/过氧化物酶级联固载体系绿色合成聚苯胺
Nadya V Dencheva,Joana F Braz,Sofia A Guimarães et al.
Nadya V Dencheva et al.
This study discloses the noncovalent immobilization of a bienzyme cascade composed of glucose oxidase (GOx) and horseradish peroxidase (HRP) onto magnetically responsive polyamide microparticles (PA MPs). Porous PA6, PA4, and PA12 MPs conta...
Mass Spectrometric Fingerprinting to Detect Fraud and Herbal Adulteration in Plant Food Supplements [0.03%]
基于质谱指纹图谱的植物食品补充剂检测欺诈及草药掺假的方法
Surbhi Ranjan,Tanika Van Mulders,Koen De Cremer et al.
Surbhi Ranjan et al.
Mass spectrometric (MS) fingerprinting coupled with chemometrics for the detection of plants in plant mixtures is sparsely researched. This paper aims to check its value for herbal adulteration concerning plants with slimming as an indicati...