Targeting RARγ Decreases Immunosuppressive Macrophage Polarization and Reduces Tumor Growth [0.03%]
靶向RARγ减少免疫抑制型巨噬细胞极化并降低肿瘤生长
Jihyeon Park,Jisun Oh,Sang-Hyun Min et al.
Jihyeon Park et al.
Tumor-associated macrophages (TAMs) play a critical role in the tumor microenvironment (TME), interacting with cancer cells and other components to promote tumor growth. Given the influence of TAMs on tumor progression and resistance to the...
The Urate-Lowering Effects and Renal Protective Activity of Iridoid Glycosides from Paederia foetida in Rats with Hyperuricemia-Induced Kidney Injury: A Pharmacological and Molecular Docking Study [0.03%]
Paederia foetida 防己黄檀素甘草酸体外及体内降尿酸作用及其分子对接机制研究
Haifeng Zhou,Xinyi Yue,Longhai Shen et al.
Haifeng Zhou et al.
(1) Background: The urate-lowering effects of three iridoid glycosides, which are paederosidic acid, paederosidic acid methyl ester, and paederoside, isolated from Paederia foetida and the protection they provide against hyperuricemia-induc...
Comparative Nitrene-Transfer Chemistry to Olefins Mediated by First-Row Transition Metal Catalysts Supported by a Pyridinophane Macrocycle with N4 Ligation [0.03%]
基于吡啶并富环大环配体的低 valence 第二周期过渡金属活化亚胺阴离子与烯烃反应性研究
Himanshu Bhatia,Lillian P Adams,Ingrid Cordsiemon et al.
Himanshu Bhatia et al.
A 12-membered pyridinophane scaffold containing two pyridine and two tertiary amine residues is examined as a prototype ligand (tBuN4) for supporting nitrene transfer to olefins. The known [(tBuN4)MII(MeCN)2]2+ (M = Mn, Fe, Co, and Ni) and ...
Potential of Quercetin as a Promising Therapeutic Agent Against Type 2 Diabetes [0.03%]
檞皮素作为治疗2型糖尿病的潜在药物功效
Przemysław Niziński,Anna Hawrył,Paweł Polak et al.
Przemysław Niziński et al.
Quercetin (QE) is a naturally occurring flavonoid found in many fruits, vegetables, and other plant-based foods. It is recognized for its diverse pharmacological activities. Among its many therapeutic potentials, its antidiabetic properties...
Olive Pomace Extract Acts as a New Potent Ferroptosis Inhibitor in Human Cells [0.03%]
橄榄渣提取物作为人体细胞中一种新的 potent ferroptosis 抑制剂
Edoardo Giuseppe Di Leo,Chiara Stranieri,Gianni Zoccatelli et al.
Edoardo Giuseppe Di Leo et al.
The olive oil-production sector engages with the environment on multiple levels, and the valorization of olive pomace (OP) has emerged as a key strategy to improve the entire system's sustainability. Numerous studies have investigated the b...
Focused Solar-Induced Construction of Activated Solar Carbon@Carbon Fiber Coaxial Electrode from Waste Carbon Fiber-Reinforced Polymer and Its Supercapacitor Performance [0.03%]
废弃碳纤维增强聚合物太阳能聚焦活化制备碳基 coax 电极及超级电容器性能研究
Chongjun Zhao,Tenghui Huang,Yingying Rong et al.
Chongjun Zhao et al.
Carbon layer-coated μm-sized carbon fiber has the potential to be developed as an electrode, as it can be directly used as an electrode without any preparation process in the absence of an insulating binder. In our work, a carbon layer-coa...
Influence of Plant-Based Substrate Composition and Extraction Method on Accumulation of Bioactive Compounds in Hericium erinaceus (Bull.) Pers. Fruiting Bodies [0.03%]
栽培基质配方及提取方法对 Erinaceus 药用功效成分积累的影响
Katarzyna Kała,Małgorzata Cicha-Jeleń,Katarzyna Sułkowska-Ziaja et al.
Katarzyna Kała et al.
The selection of plant-based substrates for mushroom cultivation is a key factor influencing their growth and metabolism. The aim of this study was to demonstrate, in an innovative approach, differences in the content of biologically active...
Cu2+ Intercalation and Structural Water Enhance Electrochemical Performance of Cathode in Zinc-Ion Batteries [0.03%]
铜离子插层和结构水促进锌离子电池正极电化学性能提升
He Lin,Mengdong Wei,Yu Zhang
He Lin
This study investigates the performance of Cu-intercalated V3O7·H2O (CuVOH) as a cathode material for aqueous zinc-ion batteries (AZIBs). Density Functional Theory (DFT) calculations were conducted to explore the effects of Cu2+ incorporat...
Immunological Insights into Photodynamic Therapy of Glioblastoma Multiforme [0.03%]
光动力疗法治疗多形性胶质母细胞瘤的免疫学见解
Paweł Woźnicki,Dorota Bartusik-Aebisher,Agnieszka Przygórzewska et al.
Paweł Woźnicki et al.
The Gliomas account for 81% of all malignant central nervous system tumors and are classified by WHO into four grades of malignancy. Glioblastoma multiforme (GBM), the most common grade IV glioma, exhibits an extremely aggressive phenotype ...
Synergic Effect of Methyl-β-Cyclodextrin and Hydrophilic Polymers on Nepafenac Solubilization: Development of a 0.3% Ophthalmic Solution [0.03%]
甲基-β-环糊精与亲水性聚合物对萘帕芬钠增溶的协同作用：开发0.3%奈帕芬纳滴眼液
Maria Grazia Saita,Fabiola Spitaleri,Katia Mangano et al.
Maria Grazia Saita et al.
Nepafenac is an anti-inflammatory drug used in ophthalmology, marketed as a suspension due to its low aqueous solubility. A solution formulation could provide better bioavailability than suspension and facilitate single unit doses, avoiding...