Polyphosphoramidate Glycohydrogels with Biorecognition Properties and Potential Antibacterial Activity [0.03%]
具有生物识别性能和潜在抗菌活性的多磷酰胺糖水凝胶
Zornica Todorova,Oyundari Tumurbaatar,Violeta Mitova et al.
Zornica Todorova et al.
In the present study, for the first time, a biodegradable and non-toxic polyphosphoramidate glycohydrogel (PPAGHGel) was prepared by crosslinking a polyphosphoramidate glycoconjugate (PPAG) with hexamethylene diisocyanate (HMDI) under mild ...
Neuroprotective Evaluation of Murraya Carbazoles: In Vitro and Docking Insights into Their Anti-AChE and Anti-Aβ Activities [0.03%]
Mitrafoline及小檗碱类化合物的神经保护活性评价及作用机制研究
Himadri Sharma,Niti Sharma,Seong Soo A An
Himadri Sharma
The present study investigated the neuroprotective potential of the Murraya carbazole derivatives murrayanol, mahanimbine, murrayafoline A, and 9-methyl-9H-carbazole-2-carbaldehyde using in silico and in vitro assays. The pharmacokinetic pr...
Therapeutic Drug Monitoring of Everolimus Using Volumetric Absorptive Microsampling and Quantitative Dried Blood Spot Methods with LC-MS/MS in Adult Solid Organ Transplant Recipients: An Analytical and Clinical Comparative Study [0.03%]
用于成人实体器官移植受者的Everolimus治疗药物监测：使用VAMS和DBS方法的液相色谱-质谱法定量分析及其临床比较研究
Arkadiusz Kocur,Bartosz Olkowski,Mateusz Moczulski et al.
Arkadiusz Kocur et al.
Everolimus (EVE), an mTOR inhibitor, is widely used in solid organ transplantation (SOT) because of its immunosuppressive properties. Due to its narrow therapeutic window and significant pharmacokinetic variability, therapeutic drug monitor...
Sustainable Adhesive Formulation and Performance Evaluation of Bacterial Nanocellulose and Aloe Vera for Packaging Applications [0.03%]
用于包装应用的细菌纳米纤维素和芦荟胶的可持续粘合剂配方和性能评估
Urška Vrabič-Brodnjak,Aljana Vidmar
Urška Vrabič-Brodnjak
The development of bio-based adhesives as sustainable alternatives to synthetic formulations presents a significant opportunity for advancing environmental sustainability in packaging applications. This research aimed to develop and evaluat...
Determination of Phenylurea Herbicides in Water Samples by Magnet-Integrated Fabric Phase Sorptive Extraction Combined with High Performance Liquid Chromatography [0.03%]
基于磁性纤维固相萃取-HPLC测定水体中的三苯基脲类除草剂
Natalia Manousi,Apostolia Tsiasioti,Abuzar Kabir et al.
Natalia Manousi et al.
In this study, a magnet-integrated fabric phase sorptive extraction (MI-FPSE) protocol was developed in combination with high pressure liquid chromatography-diode array detection (HPLC-DAD) for the simultaneous determination of five phenylu...
Amino Acid Substitutions in Bacteriocin Lactolisterin BU Reveal Functional Domains Involved in Biological Activity Against Staphylococcus aureus [0.03%]
乳链菌素BU的氨基酸替代揭示了对金黄色葡萄球菌生物活性的功能域
Lazar Gardijan,Milka Malešević,Miroslav Dinić et al.
Lazar Gardijan et al.
The emergence of multidrug-resistant pathogens has driven the development of novel antimicrobial peptides (AMPs) as therapeutic alternatives. Lactolisterin LBU (LBU) is a bacteriocin with promising activity against Gram-positive bacteria, i...
The Pharmacological Evidences for the Involvement of AhR and GPR35 Receptors in Kynurenic Acid-Mediated Cytokine and Chemokine Secretion by THP-1-Derived Macrophages [0.03%]
通过THP-1源性巨噬细胞分泌的细胞因子和化学因子介导的犬尿酸对AhR和GPR35受体药理学证据的影响
Katarzyna Sawa-Wejksza,Jolanta Parada-Turska,Waldemar Turski
Katarzyna Sawa-Wejksza
Kynurenic acid (KYNA), a tryptophan metabolite, possesses immunomodulatory properties, although the molecular mechanism of this action has not yet been resolved. In the present study, the effects of KYNA on the secretion of selected cytokin...
Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery Platforms [0.03%]
噬菌体的合成与功能工程：定制抗菌、诊断和递送平台的方法
Ola Alessa,Yoshifumi Aiba,Mahmoud Arbaah et al.
Ola Alessa et al.
Bacteriophages (phages), the most abundant biological entities on Earth, have long served as both model systems and therapeutic tools. Recent advances in synthetic biology and genetic engineering have revolutionized the capacity to tailor p...
Chrysin-Loaded Extracellular Vesicles Attenuate LPS-Induced Neuroinflammation in BV2 Microglial Cells In Vitro: A Novel Neuroprotective Strategy [0.03%]
穿膜囊泡递送染料木素减轻LPS诱导的小胶质BV2细胞神经炎症：一种新的神经营养策略
Francesca Martina Filannino,Raffaella Soleti,Melania Ruggiero et al.
Francesca Martina Filannino et al.
Neuroinflammation, driven by activated microglia, contributes to the progression of neurodegenerative diseases. Extracellular vesicles mediate intercellular communication and influence immune responses. Chrysin, a natural flavone found in f...
Fast, Simple and Accurate Method for Simultaneous Determination of α-Lipoic Acid and Selected Thiols in Human Saliva by Capillary Electrophoresis with UV Detection and pH-Mediated Sample Stacking [0.03%]
一种快速、简单和准确的人体唾液α-硫辛酸和选定的巯基类化合物的同时检测方法：基于pH介导样品富集的毛细管电泳紫外检测法
Urszula Sudomir,Justyna Piechocka,Rafał Głowacki et al.
Urszula Sudomir et al.
This report presents the first method for simultaneous determination of the 2-S-lepidinium derivatives of total α-lipoic acid (LA), homocysteine (Hcy), cysteinylglycine (CysGly), and cysteine (Cys) in human saliva, using capillary electrop...