Docosahexaenoic Acid Inhibits Osteoclastogenesis via FFAR4-Mediated Regulation of Inflammatory Cytokines [0.03%]
二十碳六烯酸通过FFAR4介导的炎症因子调控抑制破骨细胞生成
Jinghan Ma,Hideki Kitaura,Fumitoshi Ohori et al.
Jinghan Ma et al.
Osteoclastogenesis-the activation and differentiation of osteoclasts-is one of the pivotal processes of bone remodeling and is regulated by RANKL/RANK signaling, the decoy function of osteoprotegerin (OPG), and a cascade of pro- and anti-in...
A Novel Glucosamine-Based Cannabidiol Complex Based on Intermolecular Bonding with Improved Water Solubility [0.03%]
一种基于分子间相互作用的新型葡糖胺基大麻二酚复合物及其改善的水溶性
Mitja Križman,Jure Zekič,Primož Šket et al.
Mitja Križman et al.
In this study, a new, patented form of a water-soluble cannabidiol (CBD) complex was synthesised and tested. The formation of the complex is based on the interactions, presumably through hydrogen bonding, between cannabidiol and glucosamine...
Extraction Methods of Microplastics in Environmental Matrices: A Comparative Review [0.03%]
环境基质中微塑料的提取方法比较研究
Garbiñe Larrea,David Elustondo,Adrián Durán
Garbiñe Larrea
Due to the growing issue of plastic pollution over recent decades, it is essential to establish well-defined and appropriate methodologies for their extraction from diverse environmental samples. These particles can be found in complex agri...
Comparative Proteomics Identified Proteins in Mung Bean Sprouts Under Different Concentrations of Urea [0.03%]
不同浓度尿素处理下绿豆芽 Comparative Proteomics 谱图的蛋白质识别
Lifeng Wu,Chunquan Chen,Xiaoyu Zhou et al.
Lifeng Wu et al.
Mung bean (Vigna radiate) sprouts are a popular choice among sprouted vegetables in Asia. Currently, the impact of nitrogen sources on the growth of mung bean sprouts remains poorly understood, and the underlying biological mechanisms respo...
Gallic, Aconitic, and Crocetin Acids as Potential TNF Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, ADMET Profiling, and Gene Expression Analysis [0.03%]
结合分子对接、动力学模拟、ADMET分析和基因表达分析的集成研究：以没食子酸、糖苷酸和番红花黄酸作为潜在的TNF调节剂的研究
Adolat Manakbayeva,Andrey Bogoyavlenskiy,Timur Kerimov et al.
Adolat Manakbayeva et al.
Organic acids, as natural metabolites, play crucial roles in human metabolism and health. Tumor Necrosis Factor (TNF), a pivotal mediator in immune regulation and inflammation, is a key therapeutic target. We evaluated ten organic acids as ...
Cancer Chemopreventive Potential of Claoxylon longifolium Grown in Southern Thailand: A Bioassay-Guided Isolation of Vicenin 1 as the Active Compound and In Silico Studies on Related C-Glycosyl Flavones [0.03%]
泰国南部Claoxylon longifolium的化学抗癌潜力：生物测定指导分离活性化合物vicenin 1及与相关C-糖基黄酮的分子对接研究
Chuanchom Khuniad,Lutfun Nahar,Anupam D Talukdar et al.
Chuanchom Khuniad et al.
Claoxylon longifolium (Euphorbiaceae) is an indigenous vegetable that has been used in southern Thai traditional medicine and cuisine. A bioassay-guided approach was adopted to investigate the phytochemicals and chemopreventive potential of...
Naphthalimide-Based Fluorescent Probe for Portable and Rapid Response to γ-Glutamyl Transpeptidase [0.03%]
一种萘酰亚胺类荧光探针实现谷胱甘肽转移酶的现场快速检测
Jinhu Wang,Xianchao Jia,Yihao Zhang et al.
Jinhu Wang et al.
γ-Glutamyl transpeptidase (GGT) is overexpressed in a variety of diseases, making it an important diagnostic criterion for diseases. Herein, a new fluorescence probe based on naphthalimide (Glu-MDA) was developed and employed for the rapid...
Copper(I) Complexes with Terphenyl-Substituted NPN Ligands Bearing Pyridyl Groups: Synthesis, Characterization, and Catalytic Studies in the S-Arylation of Thiols [0.03%]
带有吡啶基团的取代NPN配体的铜(I)配合物的合成，表征及在硫醇S-芳构化反应中的催化性能研究
M Trinidad Martín,Ana Gálvez Del Postigo,Práxedes Sánchez et al.
M Trinidad Martín et al.
In this study, three new terphenyl-substituted NPN ligands bearing pyridyl groups, two phosphonites and one diaminophosphine, were synthesized and fully characterized. Their coordination chemistry with copper(I) was investigated using CuBr ...
Amesilide, a New Bicyclic Polyketide from the Marine Fungus Amesia nigricolor MUT6601 [0.03%]
来自海洋真菌Amesia nigricolor MUT6601的新倍半萜聚酮类化合物Amesilide
Giang Nam Pham,Matteo Florio Furno,Juan A Garcia-Sanchez et al.
Giang Nam Pham et al.
A new bicyclic polyketide, amesilide (1), along with the previously reported metabolites, chamisides A (2), B (3), and E (4), chaetoconvosins B (5) and C (6), and chaetochromins A (7) and B (8), were isolated from the marine fungus Amesia n...
Effect of Contrasting Redox Potential Evolutions and Cap Management Techniques on the Chemical Composition of Red Wine [0.03%]
不同氧化还原电位演化和塞子管理技术对红葡萄酒化学组成的影响
Dallas J Parnigoni,Sean T Kuster,Jesus Villalobos et al.
Dallas J Parnigoni et al.
This study investigated the effects of six cap management protocols targeting contrasting oxidation-reduction potential (ORP) evolutions during alcoholic fermentation of Pinot noir wines. Treatments included twice-daily punch-downs (PD) and...