PD-1 involvement in CD8+ tumor-infiltrating lymphocytes in patients with colonic-derived peritoneal adenocarcinoma [0.03%]
PD-1在结肠来源的腹膜腺癌患者CD8+tumor-infiltrating淋巴细胞中的作用
Huihui Hu,Man Zhang
Huihui Hu
Immune checkpoint blockade with anti-programmed cell death protein 1 (PD-1) antibody has become a hot topic for the treatment of human malignancies. Here, we aimed to investigate whether the percentage of PD-1 in CD8+ tumor-infiltrating lym...
Liraglutide improves antioxidant defense in hearts of spontaneously hypertensive female rats independently of changes in blood pressure in a pre-clinical model of menopause [0.03%]
利拉鲁肽改善自发性高血压雌性大鼠心脏抗氧化防御功能独立于血压变化的临床前绝经模型中的作用机制
W C Dos Santos,S N Ronchi,L A Gonçalves et al.
W C Dos Santos et al.
Liraglutide (LIRA) is an agonist of the GLP-1 receptor used in the treatment of type 2 diabetes with a cardioprotective effect, although little is known about the effects of LIRA in post-menopause. We aimed to evaluate the effects of LIRA i...
Aerobic capacity evaluation of Sprague Dawley rats in treadmill running: comparison between protocols [0.03%]
大鼠跑步机运动有氧能力评价：不同实验方案的比较研究
C Dellavechia-De-Carvalho,M A Rebelo,C De-Moraes et al.
C Dellavechia-De-Carvalho et al.
The objective of the present study was to compare and test the applicability of different protocols for accessing aerobic capacity in Sprague Dawley rats using treadmill running. Fifteen 70-day-old adult Sprague Dawley rats (270-290 g) were...
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling [0.03%]
低强度脉冲超声通过抑制PI3K/AKT/mTOR信号传导来抑制软骨细胞衰老
Wang Han,Mengtong Guan,Bo Liao et al.
Wang Han et al.
Cellular senescence is an important cause of age-related degenerative diseases, including osteoarthritis (OA). Chondrocyte senescence is crucial in OA onset and progression. As a non-invasive, safe, and widely used physical rehabilitation f...
Potential of N-acetylcysteine in the management of low back pain: a scoping review of studies in humans and animal models [0.03%]
N-乙酰半胱氨酸在治疗下腰痛中潜在应用：人类和动物模型研究的范围审查
G Sinigaglia,L M Fortunato,M L Grillo et al.
G Sinigaglia et al.
Low back pain (LBP) is a common type of pain that causes disability and impairs cognitive function. With over 80% of adults estimated to experience LBP during their lifetime, this type of pain not only has a significant impact on the indivi...
Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease [0.03%]
Dynactin敲低通过阻断斑马鱼帕金森病模型中的自噬导致突触核蛋白聚集
Yongmei Wu,Qiang Guo,Jinfan Gan et al.
Yongmei Wu et al.
Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell bodies. Our previous study indicated that t...
Saccharomyces boulardii supplementation does not affect anaerobic power gain induced by short-term sprint interval training in physically active individuals [0.03%]
萨氏子孢子菌补充剂不会影响短期冲刺间隔训练所带来的无氧功率提高效果在经常进行身体活动的人群中的表现
A S R Hudson,A M T Lisboa,P V R Andrade et al.
A S R Hudson et al.
Sprint interval training (SIT), which consists of vigorous-intensity exercise interspersed with periods of rest or low-intensity exercise, can improve human anaerobic performance. Probiotic strains, including yeasts (e.g. Saccharomyces boul...
The extent of carbapenem-resistant encoding genes in Klebsiella pneumoniae from COVID-19 and non-COVID-19 patients in a tertiary care center, Saudi Arabia [0.03%]
来自沙特阿拉伯一家三级护理中心的COVID-19和非COVID-19患者的肺炎克雷伯菌中碳青霉烯耐药编码基因的范围研究
A Al Bshabshe,M E Hamid,E Salem et al.
A Al Bshabshe et al.
Rapid dissemination of Klebsiella pneumoniae carbapenemase (KPC) is a leading cause of treatment failure, significantly increasing morbidity and mortality rates among inpatients, particularly in the intensive care unit (ICU). This study aim...
Prevalence of invasive yeast infections in a COVID-19 intensive care unit in northeastern Brazil [0.03%]
巴西东北部一家新冠肺炎重症监护室中侵袭性酵母感染的流行情况
S M F R S Medeiros,S D Costa-Júnior,V P Perez et al.
S M F R S Medeiros et al.
The COVID-19 pandemic has caused a global crisis, overwhelming hospitals and intensive care units (ICU) and leading to an increase in nosocomial infections due to prolonged hospitalization and other risk factors. The present study evaluated...
Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function [0.03%]
黄连碱通过调节cPLA2/TRPM8/CGRP-1信号通路和增强肠屏障功能改善小鼠结肠炎
Wenbin Wu,Changcheng Shu,Lisheng Chen et al.
Wenbin Wu et al.
Coptisine (COP), a naturally occurring alkaloid, is recognized for its varied pharmacological impacts and its supportive function in intestinal well-being. However, the role of COP to protect the colonic epithelium in colitis has not been e...