A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies [0.03%]
一个多层面的概念框架：从生命周期机制到公共卫生策略以应对痴呆症问题
M J R Aliberti,J E Paiva
M J R Aliberti
Dementia is a growing global health challenge driven by population aging and unequal exposure to biological, behavioral, social, and environmental determinants across the life course. Existing evidence demonstrates that these factors accumu...
Obesity exacerbates giardiasis: metabolic, intestinal, and immune response in high-fat diet-fed gerbils [0.03%]
肥胖可加重贾第鞭毛虫病：高脂饮食喂养的沙鼠代谢、肠道和免疫反应研究
L L A Ventura,C Queiroz-Glauss,H C Santiago et al.
L L A Ventura et al.
Obesity has emerged as a critical factor influencing host-pathogen interactions and infection outcomes. However, its role in protozoan infections such as giardiasis remains poorly understood. In this study, we investigated the effects of a ...
Incidence and risk factors of refeeding syndrome in inpatients undergoing enteral and parenteral nutrition hospitalized in a university medical hospital [0.03%]
大学附属医院肠内和肠外营养治疗的住院患者发生再喂养综合征的发病率及危险因素研究
R O da Rocha,M S de Rezende,H G Oliveira et al.
R O da Rocha et al.
Refeeding syndrome (RS) encompasses electrolyte and metabolic disturbances, and its incidence depends on diagnostic criteria. We aimed to evaluate the incidence and risk factors for RS in inpatients at a university hospital in Brazil, who r...
Endocannabinoid system attenuates emotional stress-induced orofacial musculoskeletal pain in rats [0.03%]
内源大麻素系统通过阻断情感压力诱导的大鼠口颌肌肉痛发挥作用
S S Silveira,B W F Alves,M R P Lisboa et al.
S S Silveira et al.
Orofacial musculoskeletal pain (OMP) is a common feature of temporomandibular disorders (TMD), a group of conditions affecting the temporomandibular joint, chewing muscles, and associated structures. The etiology of muscular TMD is currentl...
Influence of sex and gonadal hormones on pain perception in a neuropathic pain model in old rats [0.03%]
性激素在老年坐骨神经痛模型大鼠痛觉感知中的作用
C C A Palmeira,I D G Gaudêncio,L O Contiero et al.
C C A Palmeira et al.
Despite growing evidence that nociceptive stimuli are processed and modulated by distinct neural mechanisms depending on biological sex and aging, these factors remain underrepresented in experimental and clinical pain research. Most precli...
Influence of sex and gonadal hormones on pain perception in a neuropathic pain model in old rats [0.03%]
老年大鼠性激素对神经病理性疼痛模型痛觉的影响
C C A Palmeira,I D G Gaudêncio,L O Contiero et al.
C C A Palmeira et al.
Despite growing evidence that nociceptive stimuli are processed and modulated by distinct neural mechanisms depending on biological sex and aging, these factors remain underrepresented in experimental and clinical pain research. Most precli...
The flavonoid isoliquiritigenin promotes lifespan extension of Caenorhabditis elegans through the transcription factor DAF-16 and aquaporin-2 [0.03%]
异甘草素通过DAF-16转录因子和水通道蛋白AQP-2促进秀丽隐杆线虫寿命延长
Xuan Zhao,Limei Ren,Dandan Gu et al.
Xuan Zhao et al.
Aging is associated with the accumulation of oxidative damage. Isoliquiritigenin (ISL), a natural flavonoid, exhibits antioxidant properties, but its effect on lifespan and the underlying mechanisms remains incompletely understood. This stu...
Association between sedentary behavior and daily step count with physical performance of community-dwelling older adults participating in an exercise program interrupted by the COVID-19 pandemic: a cross-sectional study in Brazil [0.03%]
久坐行为和每日步数与因COVID-19大流行中断锻炼计划的社区居住老年人身体表现之间的关系：巴西的一项横断面研究
V R S Santos,G Cassemiliano,A C S Farche et al.
V R S Santos et al.
One of the effects of the COVID-19 pandemic was the interruption of exercise programs for older adults, significantly impacting their physical performance (PP). Few studies have identified the effects of the interruption of exercise program...
Home death versus hospital death: a retrospective analysis of patients in palliative care [0.03%]
居家逝世与医院逝世：对临终患者的一项回顾性分析
R D Bittencourt,S Krasilcic,I M da Silva et al.
R D Bittencourt et al.
Respecting the patient's preferred place of death is a key indicator of the quality of palliative care. However, clinical factors may influence this outcome. This study aimed to compare the clinical profiles, symptom burden, and medical int...
Inhibition of membrane RANKL production in osteoblasts mediates curcumin-inhibited osteoclastogenesis [0.03%]
姜黄素抑制破骨细胞生成的机理是抑制成骨细胞膜RANKL的产生
Tingwei Gao,Tie Ke,Zhanhao Xiao et al.
Tingwei Gao et al.
Curcumin inhibits osteoclastogenesis and mitigates osteoporosis. Our data demonstrated that curcumin decreases membrane-bound RANKL (mRANKL) levels on osteoblasts. Notably, mRANKL exerts a more prominent role in osteoclastogenesis than its ...