Home death versus hospital death: a retrospective analysis of patients in palliative care [0.03%]
居家逝世与医院逝世：对临终患者的一项回顾性分析
R D Bittencourt,S Krasilcic,I M da Silva et al.
R D Bittencourt et al.
Respecting the patient's preferred place of death is a key indicator of the quality of palliative care. However, clinical factors may influence this outcome. This study aimed to compare the clinical profiles, symptom burden, and medical int...
Inhibition of membrane RANKL production in osteoblasts mediates curcumin-inhibited osteoclastogenesis [0.03%]
姜黄素抑制破骨细胞生成的机理是抑制成骨细胞膜RANKL的产生
Tingwei Gao,Tie Ke,Zhanhao Xiao et al.
Tingwei Gao et al.
Curcumin inhibits osteoclastogenesis and mitigates osteoporosis. Our data demonstrated that curcumin decreases membrane-bound RANKL (mRANKL) levels on osteoblasts. Notably, mRANKL exerts a more prominent role in osteoclastogenesis than its ...
A clinical drug-drug interaction assessment using physiologically based pharmacokinetic modeling: a case study with chloroquine and colchicine [0.03%]
基于生理的药代动力学模型的临床药物-药物相互作用评估：氯喹和秋水仙碱的案例研究
T R Maciel,F E G Teixeira,I C Bitencourt et al.
T R Maciel et al.
The combination of drugs for malaria treatment holds promise, although the potential for drug-drug interactions remains insufficiently explored in novel therapeutic combinations. This study aims to assess these interactions using physiologi...
Electroacupuncture alleviates Parkinson's disease-related pain by inhibiting microglial NLRP3-ASC inflammasome in the amygdala [0.03%]
电针通过抑制杏仁核小胶质细胞NLRP3-ASC炎性小体的活化缓解帕金森病相关疼痛
Xiao-Wei Wang,Ben-Fan Zhu,Ying Shi et al.
Xiao-Wei Wang et al.
This study aimed to investigate the role of microglia and NOD-like receptor protein 3 (NLRP3) inflammasome-mediated neuroimmune pathways in the analgesic effects of electroacupuncture (EA) in a mouse model of Parkinson's disease (PD). Male ...
Capsinoids treatment reduces steatosis with consequent attenuation in the progression of metabolic dysfunction-associated steatotic liver disease in obese rats [0.03%]
辣椒素类似物治疗可减少肥胖大鼠的肝脂肪变性并延缓与代谢功能障碍相关联的脂肪性肝病的发展
L M Simmer,F M Nunes,K C C Santos et al.
L M Simmer et al.
Among the morbidities triggered by obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) stands out, with its progression resulting from the deposition of lipid molecules in the liver. There is a growing interest in natu...
ZNF821 as a potential biomarker associated with immune infiltration in pancreatic adenocarcinoma [0.03%]
锌指蛋白821可能是胰腺癌免疫浸润相关生物标志物
Xiaocang Ren,Yanyan Ma,Jing Li et al.
Xiaocang Ren et al.
Pancreatic adenocarcinoma (PAAD) is a highly aggressive and lethal malignancy originating from the epithelial cells lining the pancreatic ducts. To date, no robust biomarkers have been established to reliably predict PAAD prognosis. To iden...
Spatiotemporal heterogeneity of gestational syphilis in the 1st Health Region of Pará in the Brazilian Amazon [0.03%]
巴西亚马孙帕拉第一卫生地区妊娠期梅毒的时空异质性
K R Silva,R G Silva,R J P S Guimarães et al.
K R Silva et al.
Syphilis in pregnant women remains an important public health problem in Brazil, especially in urban contexts marked by social inequalities and weaknesses in the organization of health services. In the Amazon region, territorial, socioecono...
Pulmonary infection by non-tuberculous mycobacteria in an endemic region for tuberculosis in Northeast Brazil [0.03%]
巴西东北部地区肺结核流行区非结核分枝杆菌的肺感染
A S Lima,W H V Carvalho-Silva,K M Gomes et al.
A S Lima et al.
A wide range of non-tuberculous mycobacteria (NTM) species have been identified worldwide, with increasing recognition of their clinical importance in pulmonary disease. To evaluate the diversity, frequency, antimicrobial resistance profile...
Zingerone alleviates diabetic nephropathy by interrupting the ER stress-inflammation-apoptosis cascade in streptozotocin-induced diabetic mice [0.03%]
红辣椒素类似物基翁醇通过打断内质网应激-炎症-凋亡级联通路缓解链脲佐菌素诱导的糖尿病小鼠肾病
Bi Ke,Xiaojing Xiong,Chen Wang et al.
Bi Ke et al.
Endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate the protective effects of zingerone on the kidney and elucidate the underlying mechanisms in strepto...
Helicobacter pylori outer membrane vesicle-induced hsa-miR-302a-3p and hsa-miR-184 promote the occurrence and development of gastric cancer [0.03%]
幽门螺旋杆菌外膜囊泡通过诱导hsa-miR-302a-3p和hsa-miR-184促进胃癌发生发展
Yang Wen,Xiaoqing Deng,Sisi Wei et al.
Yang Wen et al.
Helicobacter pylori (H. pylori) is a major gastric cancer pathogen. Recent studies have linked H. pylori infection to microRNA (miRNA) dysregulation. H. pylori outer membrane vesicles (OMVs) support bacterial survival and pathogenesis, but ...