Sensitizer-Induced Basophils Accelerate Skin Re-Epithelialization via IL-4/IL-13-Mediated Macrophage Polarization [0.03%]
致敏素诱导的基质细胞通过介导的巨噬细胞极化加速皮肤再上皮化
Yufei Zhang,Xueting Peng,Kaixuan Ren et al.
Yufei Zhang et al.
Background: Atopic dermatitis (AD) patients exhibit a paradox of impaired skin barrier with intense itching, yet often demonstrate rapid re-epithelialization after scratching. While basophils are key effector cells in all...
Gunnar P Nilsson
Gunnar P Nilsson
Effect of Intramuscular Adrenaline on Histamine-Induced Hypotension: A Randomised Placebo-Controlled Pilot Trial [0.03%]
肾上腺素对组胺诱导的低血压影响的随机、安慰剂对照试点试验
Matthias Weiss-Tessbach,Al Medina Dizdarevic,Thorsten Bischof et al.
Matthias Weiss-Tessbach et al.
Background: Intramuscular adrenaline (epinephrine) is the first-line treatment for anaphylaxis. This recommendation is based purely on consensus, not randomised controlled trials. In humans, hypotension and shock strongly...
Algorithms in Allergy: General Allergen Molecule-Based Algorithm for Allergen-Specific Immunotherapy [0.03%]
基于过敏原分子的算法用于过敏特异性免疫疗法
Huey-Jy Huang,Daria Trifonova,Pia Gattinger et al.
Huey-Jy Huang et al.
Ru-Xin Foong,George Du Toit,Henry T Bahnson et al.
Ru-Xin Foong et al.
Background: The prevalence of sesame allergy (SA) is increasing but little is known about how it changes over time. Our aims were to observe the natural history of sesame over time and the changes in biomarkers between se...
Exhaled Volatile Organic Compounds Identify Allergic Patients Among Individuals With Chronic Rhinitis [0.03%]
呼出挥发性有机化合物可识别慢性鼻炎患者中的过敏患者
Rosa Alba Sola-Martinez,Laura Zubiaga-Fernandez,Marta Figuerola et al.
Rosa Alba Sola-Martinez et al.
Background: The nasal allergen challenge (NAC) is the gold standard to diagnose allergic rhinitis (AR) and local allergic rhinitis (LAR), but its clinical use remains limited. We investigated whether volatile organic comp...
Identification of Key Genes Associated With Epithelial Barrier Dysfunction by Comprehensive Analysis and Experimental Validation [0.03%]
全面分析与实验验证鉴定与上皮屏障功能障碍相关的关键基因
Shixiu Liang,Meihua Dong,Xiaodi Zhu et al.
Shixiu Liang et al.
Background: Epithelial barrier dysfunction is a pivotal feature of asthma, and it also commonly occurs in other inflammatory conditions such as atopic dermatitis (AD) and ulcerative colitis (UC). However, the core regulat...
Autosomal Dominant Hyper-IgE Syndrome Patients Retain IL10-Producing preTh17-Cells That Are Activated by Opportunistic Pathogens and Support IgE Production [0.03%]
自身显性高IgE综合征患者的preTh17细胞保留产生IL10的功能，并且会被机会致病菌激活以支持IgE的生成
Giorgia Moschetti,Chiara Vasco,Francesca Clemente et al.
Giorgia Moschetti et al.
Background: Autosomal Dominant-Hyper-IgE Syndrome (AD-HIES) is caused by dominant-negative (DN) STAT3 mutations and characterized by high IgE levels, a lack of Th17-cells, and recurrent infections with extracellular patho...
Live Zoster Vaccination and Reduced Risk of Atopic Dermatitis and Allergic Rhinitis [0.03%]
带状疱疹活疫苗与特应性皮炎和过敏性鼻炎发病风险降低的关系
Kyeongmin Lee,Tae Hyeon Kim,Sooji Lee et al.
Kyeongmin Lee et al.
A One-Strength Dose Escalation Regimen for Birch Pollen SCIT Is Safe and Tolerable in Children, Adolescents, and Adults [0.03%]
单剂量递增的欧洲白蜡树花粉皮下免疫治疗在儿童、青少年和成人中安全且可耐受
Marek Jutel,Ludger Klimek,Michael Gerstlauer et al.
Marek Jutel et al.
Background: Allergen immunotherapy is the only disease-modifying treatment for IgE-mediated diseases for patients 5 years and over. The question is often asked why children receive the same doses as adults. There is not a...